Cited by 141Hormonal and reproductive studiesSexual function and dysfunction studiesAdrenal Hormones and Disorders

The DOI matches its Crossref record; 65 of the 67 references it cites were found in a registry or an index.

Effects of Testosterone Supplementation on Depressive Symptoms and Sexual Dysfunction in Hypogonadal Men with the Metabolic Syndrome

Giltay, Erik J., Tishova, Yuliya A., Mskhalaya, George J., Gooren, Louis J.G., Saad, Farid, Kalinchenko, Svetlana Y.·2010·The Journal of Sexual Medicine

DOI 10.1111/j.1743-6109.2010.01859.x

Open this paper in CoChat — free account

Abstract

Introduction: Low testosterone levels in men are associated with the metabolic syndrome (MetS) as well as with depressive symptoms, low vitality, and sexual dysfunction. Aim: To assess the effects of testosterone administration on these subjective symptoms, which have not extensively been studied in hypogonadal men with the MetS. Main Outcome Measures: The Beck Depression Inventory (BDI-IA), Aging Males’ Symptoms (AMS) scale, and International Index of Erectile Function 5-item (IIEF-5) scale at baseline, 18 and 30 weeks were analysed using multilevel analysis. Methods: In a randomized, placebo-controlled, double-blind, phase III trial (ClinicalTrials.gov identifier: NCT00696748), 184 men suffering from both the MetS and hypogonadism were included. They were treated for 30 weeks with either parenteral testosterone undecanoate (TU; 1,000 mg IM TU, at baseline, and after 6 and 18 weeks; Nebido®) or placebo injections, 105 (92.9%) men receiving TU and 65 (91.5%) receiving placebo completed the 30-week trial. Results: The 184 men were aged mean 52.1 years old (standard deviation [SD] 9.6; range 35–69), with a mean body mass index of 35.5 kg/m2 (SD 6.7; range 25.1–54.8), and a mean total testosterone level of 8.0 nmol/L (SD 4.0). There were significant improvements in BDI-IA (mean difference vs. placebo after 30 weeks: −2.5 points; 95% confidence interval [CI]: −0.9; −4.1; P = 0.003), AMS (−7.4 points; 95% CI: −4.3; −10.5; P <0.001), and IIEF-5 (+3.1 points; 95% CI: +1.8; +4.4; P <0.001). The effects on the BDI-IA, AMS, and IIEF-5 were strongest in men with baseline total testosterone levels <7.7 mmol/L (i.e., median value). Conclusions: TU administration may improve depressive symptoms, aging male symptoms and sexual dysfunction in hypogonadal men with the MetS. The beneficial effects of testosterone were most evident in men with the lowest baseline total testosterone levels.

Integrity signals

Registry

Crossref · 10.1111/j.1743-6109.2010.01859.x

Cites

65 of 65 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961
Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation
Beck, A. T., Steer, R. A., & Carbin, M. G. (1988) · Clinical Psychology Review · doi:10.1016/0272-7358(88)90050-5 · Cited by 11,696
The metabolic syndrome—a new worldwide definition
Alberti, K. G. M., Zimmet, P., & Shaw, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67402-8 · Cited by 9,352
The metabolic syndrome
Eckel, R. H., Alberti, K., Grundy, S. M., & Zimmet, P. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61794-3 · Cited by 6,317
Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients
Beck, A. T., Steer, R. A., Ball, R., & Ranieri, W. F. (1996) · Journal of Personality Assessment · doi:10.1207/s15327752jpa6703_13 · Cited by 5,965
The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction
Rosen, R. C., Riley, A., Wagner, G., Osterloh, I. H., Kirkpatrick, J., & Mishra, A. (1997) · Urology · doi:10.1016/s0090-4295(97)00238-0 · Cited by 5,849
A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
Vermeulen, A., Verdonck, L., & Kaufman, J. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6079 · Cited by 3,824
Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction
Rosen, R., Cappelleri, J. C., Smith, M., Lipsky, J., & Peña, B. (1999) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3900472 · Cited by 3,095
Obesity and Diabetes in the Developing World — A Growing Challenge
Hossain, P., Kawar, B., & El Nahas, M. (2007) · New England Journal of Medicine · doi:10.1056/nejmp068177 · Cited by 2,200
Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement Executive Summary
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Cardiology in Review · doi:10.1097/01.crd.0000380842.14048.7e · Cited by 1,600
The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications
Kaufman, J. M., & Vermeulen, A. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0013 · Cited by 1,079
Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline.
Bhasin, S., Cunningham, G. R., Hayes, F. J., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., & Montori, V. M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2847 · Cited by 965
Testosterone Replacement in Older Hypogonadal Men: A 12-Month Randomized Controlled Trial
Sih, R., Morley, J. E., Kaiser, F. E., Perry, H. M., Patrick, P., & Ross, C. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.6.3988 · Cited by 920
Investigation, treatment and monitoring of late-onset hypogonadism in males
Wang, C., Nieschlag, E., Swerdloff, R., Behre, H. M., Hellstrom, W. J., Gooren, L. J., Kaufman, J. M., Legros, J.-J., Lunenfeld, B., Morales, A., et al. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0601 · Cited by 867
Self-citation
Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes
Kapoor, D., Goodwin, E., Channer, K. S., & Jones, T. H. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02166 · Cited by 791
Adverse Events Associated With Testosterone Replacement in Middle-Aged and Older Men: A Meta-Analysis of Randomized, Placebo-Controlled Trials
Calof, O. M., Singh, A. B., Lee, M. L., Kenny, A. M., Urban, R. J., Tenover, J. L., & Bhasin, S. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.11.1451 · Cited by 728
Risks of testosterone-replacement therapy and recommendations for monitoring.
Rhoden, E. L., & Morgentaler, A. (2004) · New England Journal of Medicine · doi:10.1056/nejmra022251 · Cited by 705
Prospective association between obesity and depression: evidence from the Alameda County Study
Roberts, R. E., Deleger, S., Strawbridge, W. J., & Kaplan, G. A. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802204 · Cited by 674
Validation of a screening questionnaire for androgen deficiency in aging males
Morley, J. E., Charlton, E., Patrick, P., Kaiser, F. E., Cadeau, P., McCready, D., & Perry, H. M. (2000) · Metabolism · doi:10.1053/meta.2000.8625 · Cited by 662
Association of Specific Symptoms and Metabolic Risks with Serum Testosterone in Older Men
Zitzmann, M., Faber, S., & Nieschlag, E. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0401 · Cited by 552
Effect of Testosterone Supplementation on Functional Mobility, Cognition, and Other Parameters in Older Men: A Randomized Controlled Trial
Emmelot-Vonk, M. H., Verhaar, H. J. J., Nakhai Pour, H. R., Aleman, A., Lock, T. M. T. W., Bosch, J. L. H. R., Grobbee, D. E., & van der Schouw, Y. T. (2008) · JAMA · doi:10.1001/jama.2007.51 · Cited by 518
Effects of testosterone on sexual function in men: results of a meta‐analysis
Isidori, A. M., Giannetta, E., Gianfrilli, D., Greco, E. A., Bonifacio, V., Aversa, A., Isidori, A., Fabbri, A., & Lenzi, A. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02350.x · Cited by 492
Bioavailable Testosterone and Depressed Mood in Older Men: The Rancho Bernardo Study
Barrett-Connor, E., von Mühlen, D. G., & Kritz-Silverstein, D. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.2.5495 · Cited by 472
AA2500 Testosterone Gel Normalizes Androgen Levels in Aging Males with Improvements in Body Composition and Sexual Function
Steidle, C. P., Schwartz, S. L., Jacoby, K., Sebree, T. B., Smith, T. P. L., & Bachand, R. T. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021058 · Cited by 409
Testosterone and Depression: Systematic Review and Meta-Analysis
Zarrouf, F. A., Artz, S., Griffith, J., Sirbu, C., & Kommor, M. (2009) · Journal of Psychiatric Practice · doi:10.1097/01.pra.0000358315.88931.fc · Cited by 383
Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency
Boyanov, M. A., Boneva, Z., & Christov, V. G. (2003) · The Aging Male · doi:10.1080/tam.6.1.1.7 · Cited by 381
Testosterone Gel Supplementation for Men With Refractory Depression: A Randomized, Placebo-Controlled Trial
Pope, H. G., Cohane, G. H., Kanayama, G., Siegel, A. J., & Hudson, J. I. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.1.105 · Cited by 341
Associations Between Anxiety, Depression, and the Metabolic Syndrome
Skilton, M. R., Moulin, P., Terra, J., & Bonnet, F. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.01.012 · Cited by 310
ISA, ISSAM, EAU, EAA and ASA recommendations: Investigation, treatment and monitoring of late-onset hypogonadism in males
Wang, C., Nieschlag, E., Swerdloff, R. S., Behre, H. M., Hellstrom, W. J. G., Gooren, L. J., Kaufman, J., Legros, J.-J., Lunenfeld, B., Morales, Á., et al. (2008) · International Journal of Impotence Research · doi:10.1038/ijir.2008.41 · Cited by 287
Self-citation
The Short-Term Effects of High-Dose Testosterone on Sleep, Breathing, and Function in Older Men
Liu, P. Y., Yee, B., Wishart, S. M., Jimenez, M., Jung, D. G., Grunstein, R. R., & Handelsman, D. J. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030236 · Cited by 275
One year follow-up study of the association between chemical castration, sex hormones, beta-amyloid, memory and depression in men
Almeida, O. P., Waterreus, A. J., Spry, N. A., Flicker, L. A., & Martins, R. N. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2003.11.002 · Cited by 255
Depression: An Important Comorbidity With Metabolic Syndrome in a General Population
Dunbar, J. A., Reddy, P., Davis-Lameloise, N., Philpot, B., Laatikainen, T., Kilkkinen, A., Bunker, S. J., Best, J. D., Vartiainen, E., Kai Lo, S., et al. (2008) · Diabetes Care · doi:10.2337/dc08-0175 · Cited by 241
A Double-Blind, Placebo-Controlled, Randomized Clinical Trial of Transdermal Dihydrotestosterone Gel on Muscular Strength, Mobility, and Quality of Life in Older Men with Partial Androgen Deficiency
Ly, L. P., Jimenez, M., Zhuang, T. N., Celermajer, D. S., Conway, A. J., & Handelsman, D. J. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7821 · Cited by 239
Androgen Receptor Gene CAG Repeat Length and Body Mass Index Modulate the Safety of Long-Term Intramuscular Testosterone Undecanoate Therapy in Hypogonadal Men
Zitzmann, M., & Nieschlag, E. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0620 · Cited by 216
Intramuscular Testosterone Undecanoate: Pharmacokinetic Aspects of a Novel Testosterone Formulation during Long-Term Treatment of Men with Hypogonadism
Schubert, M., Minnemann, T., Hübler, D., Rouskova, D., Christoph, A., Oettel, M., Ernst, M. E., Mellinger, U., Krone, W., & Jockenhövel, F. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0897 · Cited by 187
The Aging Males’ Symptoms (AMS) scale: update and compilation of international versions
(2003) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-1-15 · Cited by 186
Self-citation
Testosterone use in men with sexual dysfunction: a systematic review and meta-analysis of randomized placebo-controlled trials
Boloña, E. R., Uraga, M. V., Haddad, R. M., Tracz, M. J., Sideras, K., Kennedy, C. C., Caples, S. M., Erwin, P. J., & Montori, V. M. (2007) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)60963-4 · Cited by 184
Metabolic Syndrome Predisposes to Depressive Symptoms
Koponen, H., Jokelainen, J. J., Keinanen-Kiukaanniemi, S. M., Kumpusalo, E. A., & Vanhala, M. J. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0202 · Cited by 178
ISA, ISSAM, EAU, EAA and ASA recommendations: investigation, treatment and monitoring of late-onset hypogonadism in males
Wang, C., Nieschlag, E., Swerdloff, R. S., Behre, H. M., Hellstrom, W. J. G., Gooren, L. J., Kaufman, J., Legros, J.-J., Lunenfeld, B., Morales, Á., et al. (2008) · The Aging Male · doi:10.1080/13685530802389628 · Cited by 176
Self-citation
Androgen deficiency, diabetes, and the metabolic syndrome in men
Kalyani, R. R., & Dobs, A. S. (2007) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32814db856 · Cited by 173
Low Testosterone Levels Predict Incident Depressive Illness in Older Men: Effects of Age and Medical Morbidity
Shores, M. M., Moceri, V. M., Sloan, K. L., Matsumoto, A. M., & Kivlahan, D. R. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0102 · Cited by 166
Testosterone Replacement Therapy for Hypogonadal Men With Major Depressive Disorder
Seidman, S. N., Spatz, E. S., Rizzo, C., & Roose, S. P. (2001) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v62n0602 · Cited by 165
Risk of the "Androgen Deprivation Syndrome" in Men Receiving Androgen Deprivation for Prostate Cancer
Shahinian, V. B., Kuo, Y., Freeman, J. L., & Goodwin, J. S. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.4.465 · Cited by 162
Association Between Metabolic Syndrome and Depressive Symptoms in Middle-Aged Adults
Akbaraly, T. N., Mika Kivimaki, B., Brunner, E. J., Chandola, T., Marmot, M. G., Singh‐Manoux, A., & Ferrie, J. E. (2008) · Diabetes Care · doi:10.2337/dc08-1358 · Cited by 161
Effects of Testosterone on Behavior, Depression, and Cognitive Function in Older Men With Mild Cognitive Loss
Kenny, R. A., Fabregas, G., Song, C., Biskup, B., & Bellantonio, S. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.1.m75 · Cited by 160
Low Free Testosterone Concentration as a Potentially Treatable Cause of Depressive Symptoms in Older Men
Almeida, O. P., Yeap, B. B., Hankey, G. J., Jamrozik, K., & Flicker, L. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.33 · Cited by 158
The Effects of Transdermal Dihydrotestosterone in the Aging Male: A Prospective, Randomized, Double Blind Study
Kunelius, P., Lukkarinen, O. A., Hannuksela, M. L., Itkonen, O., & Tapanainen, J. S. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8138 · Cited by 141
The Aging Males' Symptoms (AMS) scale: review of its methodological characteristics.
Daig, I., Heinemann, L. A. J., Kim, S., Leungwattanakij, S., Badia, X. C., Myon, E., Moore, C., Saad, F., Potthoff, P., & Thai, D. M. (2003) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-1-77 · Cited by 137
Self-citation
The Aging Males’ Symptoms Scale (AMS) as Outcome Measure for Treatment of Androgen Deficiency
Moore, C., Huebler, D., Zimmermann, T. P., Heinemann, L. A. J., Saad, F., & Thai, D. M. (2004) · European Urology · doi:10.1016/j.eururo.2004.01.009 · Cited by 132
Self-citation
Effect of oral testosterone undecanoate on visuospatial cognition, mood and quality of life in elderly men with low-normal gonadal status
Haren, M. T., Wittert, G., Chapman, I. M., Coates, P. S., & Morley, J. E. (2004) · Maturitas · doi:10.1016/j.maturitas.2004.05.002 · Cited by 124
Low Levels of Androgens in Men with Erectile Dysfunction and Obesity
Corona, G., Mannucci, E., Fisher, A. D., Lotti, F., Petrone, L., Balercia, G., Bandini, E., Forti, G., & Maggi, M. (2008) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.00856.x · Cited by 124
A Randomized, Double-Blind, Placebo-Controlled Study of Testosterone Treatment in Hypogonadal Older Men With Subthreshold Depression
Shores, M. M., Kivlahan, D. R., Sadak, T. I., Li, E. J., & Matsumoto, A. M. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04478 · Cited by 123
Depressive Symptoms and Metabolic Risk in Adult Male Twins Enrolled in the National Heart, Lung, and Blood Institute Twin Study
McCaffery, J. M., NIAURA, R. S., Todaro, J. F., Swan, G. E., & Carmelli, D. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000041545.52924.82 · Cited by 118
Calculated bioavailable testosterone levels and depression in middle-aged men
McIntyre, R. S., Mancini, D., Eisfeld, B. S., Soczynska, J. K., Grupp, L. A., Konarski, J. Z., & Kennedy, S. H. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.06.005 · Cited by 110
Testosterone and depression in men
Amiaz, R., & Seidman, S. N. (2008) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3282fc27eb · Cited by 91
Oral testosterone replacement in symptomatic late-onset hypogonadism: effects on rating scales and general safety in a randomized, placebo-controlled study
Legros, J., MEULEMAN, E. J. H., Elbers, J. M. H., Geurts, T. B. P., Kaspers, M. J. G. H., Bouloux, P. M., & _, _. (2009) · European Journal of Endocrinology · doi:10.1530/eje-08-0634 · Cited by 87
Testosterone Therapy in Late-Life Major Depression in Males
Perry, P. J., Yates, W. R., Williams, R. D., Andersen, A. E., MacIndoe, J. H., Lund, B. C., & Holman, T. L. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n1202 · Cited by 75
Intramuscular Testosterone Supplementation to Selective Serotonin Reuptake Inhibitor in Treatment-Resistant Depressed Men
Seidman, S. N., Miyazaki, M., & Roose, S. P. (2005) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000185424.23515.e5 · Cited by 70
Hypogonadism, Decreased Sexual Desire, and Long-Term Depression in Middle-Aged Men
Hintikka, J. J., NISKANEN, L. K., Koivumaa-Honkanen, H. T., Tolmunen, T., Honkalampi, K. M., Lehto, S. M., & Viinamäki, H. T. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01299.x · Cited by 66
Transdermal testosterone gel increases serum testosterone levels in hypogonadal men in Taiwan with improvements in sexual function
Chiang, H., Hwang, T. I. S., Hsui, Y. S., Lin, Y., Chen, H. E., Chen, G. C., & Liao, C. (2007) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901562 · Cited by 58
The effect of testosterone on health-related quality of life in elderly males - a pilot study
Reddy, P., White, C. M., Dunn, A. B., Moyna, N. M., & Thompson, P. D. (2000) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1046/j.1365-2710.2000.00309.x · Cited by 57
Double‐blind placebo‐controlled study of testosterone patch therapy on bone turnover in men with borderline hypogonadism
Merza, Z., Blumsohn, A., Mah, P., Meads, D. M., McKenna, S. P., Wylie, K. R., Eastell, R., Wu, F. C. W., & Ross, R. J. M. (2005) · International Journal of Andrology · doi:10.1111/j.1365-2605.2005.00612.x · Cited by 54
The Relationship between Testosterone and Sexual Function in Depressed and Healthy Men
Rizvi, S. J., Kennedy, S. H., Ravindran, L. N., Giacobbe, P., Eisfeld, B. S., Mancini, D., & McIntyre, R. S. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01504.x · Cited by 44
The Sexual Effects of Testosterone Replacement in Depressed Men: Randomized, Placebo-Controlled Clinical Trial
Seidman, S. N., & Roose, S. P. (2006) · Journal of Sex & Marital Therapy · doi:10.1080/00926230600575355 · Cited by 40
The aging male: androgens, erectile dysfunction, and depression.
Seidman, S. N. (2003) · PubMed · Cited by 11

Sorted by citations

Erectile dysfunction
Yafi, F. A., Jenkins, L., Albersen, M., Corona, G., Isidori, A. M., Goldfarb, S., Maggi, M., Nelson, C. J., Parish, S., Salonia, A., et al. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.3 · Cited by 853
Testosterone and Cardiovascular Disease
Kloner, R. A., Carson, C., Dobs, A., Kopecky, S., & Mohler, E. R. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.12.005 · Cited by 371
A Critical Analysis of the Role of Testosterone in Erectile Function: From Pathophysiology to Treatment—A Systematic Review
Isidori, A. M., Buvat, J., Corona, G., Goldstein, I., Jannini, E. A., Lenzi, A., Porst, H., Salonia, A., Traish, A. M., & Maggi, M. (2013) · European Urology · doi:10.1016/j.eururo.2013.08.048 · Cited by 315
Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men
Lunenfeld, B., Mskhalaya, G. J., Zitzmann, M., Arver, S., Kalinchenko, S. Y., Tishova, Y. A., & Morgentaler, A. (2015) · The Aging Male · doi:10.3109/13685538.2015.1004049 · Cited by 318
Self-citation
Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido and Erectile Dysfunction and Depression in a Subset of Patients
Traish, A. M., Hassani, J., Guay, A. T., Zitzmann, M., & Hansen, M. L. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.02157.x · Cited by 283

See all 141

Authors: Giltay, E. J., Tishova, Y. A., Mskhalaya, G. J., Gooren, L. J. G., Saad, F., & Kalinchenko, S. Y.
Affiliations: Leiden University Medical Center (NL)
Peoples' Friendship University of Russia (RU)
Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Gulf Medical University (AE)
Corresponding author: Giltay, Erik J.
ORCID: Giltay, Erik J.
Gooren, Louis J.G.
Saad, Farid
Venue: The Journal of Sexual Medicine
Publisher: Oxford University Press (OUP)
Published: 2010-07-01
Volume: 7
Issue: 7
Pages: 2572-2582
ISSN: 1743-6095 (ISSN-L)
1743-6109
DOI: 10.1111/j.1743-6109.2010.01859.x
OpenAlex: W1706522822
Cited by: 140
References: 67
Citations by year: 2026: 2 · 2025: 4 · 2024: 8 · 2022: 10 · 2021: 6 · 2020: 4 · 2019: 8 · 2018: 9 · 2017: 11 · 2016: 19 · 2015: 11 · 2014: 13 · 2013: 12 · 2012: 9
FWCI: 8.47
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: The Journal of Sexual Medicine (publishedVersion)
PubMed (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Leiden Repository (Leiden University) (submittedVersion)
Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: testosterone undecanoate, testosterone supplementation, hypogonadism, metabolic syndrome, depressive symptoms, sexual dysfunction, erectile function, aging male symptoms, androgen deficiency, men's health, low energy, lack of motivation, low self-esteem, low self-confidence
MeSH terms: Adult, Age Factors, Aged, Aging, Androgens, Antidepressive Agents, Depression, Double-Blind Method, Humans, Hypogonadism, Infusions, Intravenous, Infusions, Parenteral, Male, Middle Aged, Psychometrics, Psychotropic Drugs, Surveys and Questionnaires, Regression Analysis, Statistics as Topic, Testosterone, Multivariate Analysis, Confidence Intervals, Statistics, Nonparametric, Metabolic Syndrome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effects of Testosterone Supplementation on Depressive Symptoms and Sexual Dysfunction in Hypogonadal Men with the Metabolic Syndrome

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks