The DOI matches its Crossref record.
Extracellular ion concentrations during spreading depression and ischemia in the rat brain cortex
Abstract
We compared interstitial ion concentrations in rat brain cortex during two conditions where pronounced changes are observed: spreading depression and ischemia. Initially, during the two phenomena, an increase of [K+]e from 3 to approximately 10 mM were observed, but only small changes of the other ion concentrations. Hereafter, [K+]e exhibited a rapid increase (2–3 s) to 55 mM, whereas [Na+]e rapidly decreased to 60 mM, [Cl‐]e to 75 mM, and [Ca++]e to 0.08 mM. The changes were accompanied by a rapid negative shift in the local electrical potential. However, there were differences in the ionic events during the two phenomena. In spreading depression, the initial [K+]e increase took place in 5–10 s, but in ischemia it lasted 1–2 min. The ionic perturbations were spontaneously reverted in SD, but in ischemia they proceeded further and reached after 5 min (mM): [K+]e 75, [Na+]e 50, [Cl‐]e 72, and [Ca++]e 0.06. The similar chain of ionic events during spreading depression and ischemia suggests a common mechanism for the ionic changes, probably involving changes of ionic permeability of brain cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Glial and neuronal control of brain blood flow
Attwell, D., Buchan, A. M., Charpak, S., Lauritzen, M., MacVicar, B. A., & Newman, E. A. (2010) · Nature · doi:10.1038/nature09613 · Cited by 2,511
Siesjö, B. K., & Bengtsson, F. (1989) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1989.20 · Cited by 1,231
Calcium in Ischemic Cell Death
Kristián, T., & Siesjö, B. K. (1998) · Stroke · doi:10.1161/01.str.29.3.705 · Cited by 825
Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature
Ayata, C., & Lauritzen, M. (2015) · Physiological Reviews · doi:10.1152/physrev.00027.2014 · Cited by 555
Fabricius, M., Fuhr, S., Bhatia, R., Boutelle, M., Hashemi, P., Strong, A. J., & Lauritzen, M. (2006) · Brain · doi:10.1093/brain/awh716 · Cited by 420
Hillered, L., Vespa, P. M., & Hovda, D. A. (2005) · Journal of Neurotrauma · doi:10.1089/neu.2005.22.3 · Cited by 365
Dreier, J. P., Fabricius, M., Ayata, C., Sakowitz, O. W., William Shuttleworth, C., Dohmen, C., Graf, R., Vajkoczy, P., Helbok, R., Suzuki, M., et al. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16654496 · Cited by 350
Nilsson, P., Hillered, L., Olsson, Y., Sheardown, M. J., & Hansen, A. J. (1993) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1993.22 · Cited by 276
Self-citationDreier, J. P., Isele, T., Reiffurth, C., Offenhauser, N., Kirov, S. A., Dahlem, M. A., & Herreras, O. (2013) · The Neuroscientist · doi:10.1177/1073858412453340 · Cited by 94
Voltage-dependent inhibition of brain Na (+) channels by American ginseng
Liu, D., Li, B., Liu, Y., Attele, A. S., Kyle, J. W., & Yuan, C.-S. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00735-x · Cited by 63
Therapeutic use of creatine in brain or heart ischemia: Available data and future perspectives
Perasso, L., Spallarossa, P., Gandolfo, C., Ruggeri, P., & Balestrino, M. (2013) · Medicinal Research Reviews · doi:10.1002/med.20255 · Cited by 43
Spreading depression following experimental head injury in the rat
SUNAMI, K., NAKAMURA, T., KUBOTA, M., OZAWA, Y., NAMBA, H., YAMAURA, A., & MAKINO, H. (1989) · Neurologia medico-chirurgica · doi:10.2176/nmc.29.975 · Cited by 39
Suzuki, M., Fujise, Y., Tsuchiya, Y., Tamano, H., & Takeda, A. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.05.006 · Cited by 34
Metadata
- Authors
- HANSEN, A. J., & ZEUTHEN, T.
- Venue
- Acta Physiologica Scandinavica
- Publisher
- Wiley
- Published
- 1981-12
- Volume
- 113
- Issue
- 4
- Pages
- 437-445
- ISSN
- 0001-6772 (ISSN-L)
- 1365-201X
- OpenAlex
- W1980098832
- Cited by
- 557
- References
- 0
- FWCI
- 7.13
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
