Muscle fatigue resistance during stimulated contractions is reduced in young male smokers
Open accessAbstract
Aim: To determine whether muscle function is compromised in healthy smokers in comparison with activity‐matched non‐smokers. Methods: Nine male smokers (aged 22.2 ± 2.5 years: mean ± SD) with a smoking history of 2.5 ± 3.1 pack years, and ten male control participants (25.4 ± 2.9 years) matched for physical activity level participated in this study. Knee extensor strength was measured using isometric maximal voluntary contractions. Voluntary activation of the quadriceps and co‐activation of the biceps femoris were determined using interpolated twitches and surface electromyography respectively. The frequency–torque relationship and fatigue resistance were assessed with electrically evoked contractions. A fatigue index was determined as the ratio of final torque to initial torque during a series of isometric contractions (2 min; 30 Hz; 1 s contraction/1 s rest). Quadriceps anatomical cross sectional area was measured with MRI at 50% of femur length. Results: Maximal voluntary contraction torque, quadriceps anatomical cross sectional area, knee extensor torque/quadriceps cross sectional area, activation, co‐activation and force–frequency relationship were similar, whereas the fatigue index was 17% lower in smokers than non‐smokers. Conclusion: In young men smoking does not significantly affect quadriceps muscle mass and contractile properties, but does reduce fatigue resistance of the quadriceps muscle, which was not attributable to differences in physical activity.
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Chronic consumption of cigarettes is linked to impaired muscle function.
“Furthermore, chronic consumption of cigarettes has been increasingly linked to impaired muscle function [15,16].”
From An Overlooked Bone Metabolic Disorder: Cigarette Smoking-Induced Osteoporosis (2022) · cites this paper as [15]
Long-term smoking is associated with a decline in muscle functionality and sarcopenia.
“Moreover, numerous studies have shown how long-term smoking is associated with a decline in muscle functionality and sarcopenia [9,10].”
From Skeletal System Biology and Smoke Damage: From Basic Science to Medical Clinic (2021) · cites this paper as [9]
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Skeletal System Biology and Smoke Damage: From Basic Science to Medical Clinic
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- Authors
- Morse, C. I., Wüst, R. C. I., Jones, D. A., De Haan, A., & Degens, H.
- Affiliations
- Manchester Metropolitan University (GB)
- Corresponding author
- Morse, C. I.
- Venue
- Acta Physiologica
- Publisher
- Wiley
- Published
- 2007-06-05
- Volume
- 191
- Issue
- 2
- Pages
- 123-129
- ISSN
- 1748-1708 (ISSN-L)
- 1748-1716
- OpenAlex
- W2062225405
- Cited by
- 45
- References
- 31
- Citations by year
- 2024: 3 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 7
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- green
- research.vu.nl
- Licence
- Locations
- Acta Physiologica (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- e-space (Manchester Metropolitan University) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- VU Research Portal (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Keywords
- smoking, muscle fatigue, quadriceps, knee extensors, voluntary activation, CO activation, biceps femoris, fatigue index, muscle mass, isometric contraction, young men
- MeSH terms
- Adult, Electric Stimulation, Electromyography, Humans, Isometric Contraction, Magnetic Resonance Imaging, Male, Muscle Contraction, Smoking, Case-Control Studies, Muscle, Skeletal, Statistics, Nonparametric, Muscle Fatigue
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