DHEA and Peripheral Androgen and Estrogen Formation: Intracrinology

Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood

ORENTREICH, N., BRIND, J. L., RIZER, R. L., & VOGELMAN, J. H. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-3-551 · Cited by 1,349

Important Advances in Oncology: 1986

Merrill, J. M. (1986) · JAMA · doi:10.1001/jama.1986.03380040106043 · Cited by 909

Intracrinology

Labrie, F. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90116-a · Cited by 685

A prospective study of dehydroepiandrosterone sulfate, mortality and cardiovascular disease.

Barrett-Connor, E., Khaw, K.-T., & Yen, S. S. C. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612113152405 · Cited by 681

Deletion of steroid 5α-reductase 2 gene in male pseudohermaphroditism

Andersson, S., Berman, D. M., Jenkins, E. P., & Russell, D. W. (1991) · Nature · doi:10.1038/354159a0 · Cited by 643

Male pseudohermaphroditism caused by mutations of testicular 17β-hydroxysteroid dehydrogenase 3

Geissler, W. M., Davis, D. L., Wu, L., Bradshaw, K. D., Patel, S., Mendonca, B. B., Elliston, K. O., Wilson, J. D., Russell, D. W., & Andersson, S. (1994) · Nature Genetics · doi:10.1038/ng0594-34 · Cited by 570

Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases

Andersson, S., & Russell, D. W. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.10.3640 · Cited by 501

Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity

Wu, L., Einstein, M., Geissler, W. M., Chan, H. K., Elliston, K. O., & Andersson, S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31480-7 · Cited by 437

Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men

Bèlanger, A., Candas, B., Dupont, A., Cusan, L., Diamond, P., Gomez, J.-L., & Labrie, F. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.4.7962278 · Cited by 437

Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men.

NESTLER, J. E., BARLASCINI, C. O., CLORE, J. N., & BLACKARD, W. G. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-1-57 · Cited by 414

Saliva-based Hormone Diagnostics: advances, applications, and future perspectives

Ferrari, C. R., Moraes, S. M., & Buzalaf, M. A. R. (2025) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2025.2505527 · Cited by 13

Serum sex steroids and steroidogenesis-related enzyme expression in skeletal muscle during experimental weight gain in men

Sato, K., Samocha‐Bonet, D., Handelsman, D. J., Fujita, S., Wittert, G., & Heilbronn, L. K. (2014) · Diabetes & Metabolism · doi:10.1016/j.diabet.2014.03.006 · Cited by 13

Participation of Endogenous Dehydroepiandrosterone and Its Sulfate in the Pathology of Collagen-Induced Arthritis in Mice

Kobayashi, Y., Tagawa, N., Muraoka, K., Okamoto, Y., & Nishida, M. (2003) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.26.1596 · Cited by 13

Cytosolic sulfotransferases in endocrine disruption

Duffel, M. W. (2024) · Essays in Biochemistry · doi:10.1042/ebc20230101 · Cited by 12

[Physiology of androgens in adult men].

Tostain, J.-B., Rossi, D., & Martin, P. (2004) · PubMed · Cited by 12

Steroidogenesis and Neuroplasticity in the Songbird Brain

Saldanha, C. J., & Schlinger, B. A. (2008) · Springer eBooks · doi:10.1007/978-1-4020-6854-6_10 · Cited by 12

Sex Steroids, Bone, and Aging

LeBoff, M. S., & Glowacki, J. (1999) · Elsevier eBooks · doi:10.1016/b978-012098655-2/50017-x · Cited by 13

Exclusive androgenic effect of dehydroepiandrosterone in sebaceous glands of rat skin

Sourla, A., Richard, V., Labrie, F., & Labrie, C. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1660455 · Cited by 11

Dehydroepiandrosterone and sport

Corrigan, A. B. (1999) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1999.tb123601.x · Cited by 11

Physiological levels and action of dehydroepiandrosterone in Yucatan miniature swine

Tagliaferro, A. R., & Ronan, A. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.1.r1 · Cited by 10

Aerobic exercise training and dehydroepiandrosterone administration increase testicular sex steroid hormones and enhance reproductive function in high-sucrose-induced obese rats

Tatara, K., & Sato, K. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.03.019 · Cited by 10

Synthesis of 5α-Androstane-17-spiro-δ-lactones with a 3-Keto, 3-Hydroxy, 3-Spirocarbamate or 3-Spiromorpholinone as Inhibitors of 17β-Hydroxysteroid Dehydrogenases

Djigoué, G. B., Ngatcha, B. T., Roy, J., & Poirier, D. (2013) · Molecules · doi:10.3390/molecules18010914 · Cited by 10

Endocrinology and Aging

Lamberts, S. W. J., & van den Beld, A. W. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00027-7 · Cited by 10

Role of Stress and Hormones of the Hypothalamic-Pituitary-Adrenal (HPA) Axis in Aging

Gupta, A. (2019) · Springer eBooks · doi:10.1007/978-981-13-3585-3_12 · Cited by 8

Role of Alcohol Dehydrogenases in Steroid and Retinoid Metabolism

Kedishvili, N. Y., Stone, C. L., Popov, K. M., & Chernoff, E. A. G. (1996) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-5871-2_37 · Cited by 8

Sex Steroid Effects on Bone Metabolism

Monroe, D. G., Spelsberg, T. C., & Khosla, S. (2006) · Elsevier eBooks · doi:10.1016/b978-012088562-6/50020-0 · Cited by 7

Expression of 3 beta-hydroxysteroid dehydrogenase/isomerase in the female rat pituitary

Vidal, S., Román, A., Moya, L., & Kovács, K. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1660095 · Cited by 7

Androgênios séricos e densidade mineral óssea em mulheres ooforectomizadas e não ooforectomizadas na pós-menopausa

Kulak, J., Urbanetz, A. A., Kulak, C. A. M., Borba, V. Z. C., & Boguszewski, C. L. (2009) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302009000800019 · Cited by 7

DHEA: Biology and Use in Therapeutic Intervention

Buster, J. E., & Casson, P. R. (2000) · Elsevier eBooks · doi:10.1016/b978-012453790-3/50045-7 · Cited by 7

Some reflections on the endocrinology of the aging male

Vermeulen, A. (1998) · The Aging Male · doi:10.3109/13685539809146103 · Cited by 7

The role of androgens in hormone replacement therapy

Johnson, C., & Berman, J. R. (2005) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.6.11.1815 · Cited by 6

Intracrine androgen biosynthesis and drug resistance

Penning, T. M., Asangani, I. A., Sprenger, C. C. T., & Plymate, S. R. (2020) · Cancer Drug Resistance · doi:10.20517/cdr.2020.60 · Cited by 6

Intracrine Formation of Steroid Hormones in Breast Cancer, Epidermal Keratinocyte, Dermal Fibroblast, and Adipocyte Cell Lines Measured by LC-MS/MS

Karakus, E., Schmid, A., Schäffler, A., Wudy, S. A., & Geyer, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031188 · Cited by 5

Recent Studies on Aromatase and Sulfatase Involved in Breast Cancer and their Inhibitors

Makar, S., Ghosh, A., Kumar, A., & Singh, S. K. (2020) · Current Enzyme Inhibition · doi:10.2174/1573408016666200325120248 · Cited by 5

Testosterone in Females

Cipriani, S., Maseroli, E., & Vignozzi, L. (2021) · Springer eBooks · doi:10.1007/978-3-030-77111-9_8 · Cited by 5

Sex hormones and dry eye disease: Current update

Maurya, R. P., Gupta, A. O., Verma, S., Singh, V. P., Singh, A. K., Singh, V., Roy, M., Mehla, L., & Kumar, R. (2021) · IP International Journal of Ocular Oncology and Oculoplasty · doi:10.18231/j.ijooo.2021.029 · Cited by 5

Intercellular Communication

Faruk, N. (2012) · InTech eBooks · doi:10.5772/47931 · Cited by 5

In-Vitro Determination of Biological and Anabolic Functions of Weak Androgen Dehydroepiandrosterone (DHEA) Using a Variety of Cell Lines

Cox, J. L., Chang, Y., & Ramaraj, P. (2015) · Open Journal of Endocrine and Metabolic Diseases · doi:10.4236/ojemd.2015.58014 · Cited by 4

Influence of the environment, gender, and hormones on systemic lupus erythematosus: A narrative review

Duran-Barragán, S., Bátiz-Andrade, J. P., Valenzuela-Marrufo, R. A., & Alarcón, G. S. (2021) · Revista Colombiana de Reumatología · doi:10.1016/j.rcreu.2021.02.008 · Cited by 4

Role of the Steroid Sulfate Uptake Transporter Soat (Slc10a6) in Adipose Tissue and 3T3-L1 Adipocytes

Karakuş, E., Schmid, A., Leiting, S., Fühler, B., Schäffler, A., Jakob, T., & Geyer, J. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.863912 · Cited by 4

Endocrinology and Aging

Lamberts, S. W. J. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00027-4 · Cited by 4

Combined androgen blockade and treatment of localized prostate cancer: a real hope when approaching the year 2000

Labrie, F. (1998) · Endocrine Related Cancer · doi:10.1677/erc.0.0050341 · Cited by 4

Anti-Aging: Mythen und Fakten zur Diagnose und Therapie

Zech, N. H. (2004) · Gyn�kologisch-geburtshilfliche Rundschau · doi:10.1159/000076864 · Cited by 4

Androgens, DHEA and breast cancer

Labrie, F., Poulin, R., Simard, J., Luu-The, V., Labrie, C., & Bélanger, A. (2005) · CRC Press eBooks · doi:10.1201/b14632-13 · Cited by 4

The role of microbiota and toll-like receptors in polycystic ovary syndrome: regulatory mechanisms of androgen metabolism

Huang, X., Wu, L., Zhang, Y., Lai, X., & Sun, D. (2025) · Endocrine Connections · doi:10.1530/ec-25-0162 · Cited by 3

following a single bout of exercise in rats Sex differences in steroidogenesis in skeletal muscle

Mesaki, N., Aizawa, K., Iemitsu, M., Otsuki, T., Maeda, S., Sato, K., & Fujita, S. (2013) · Cited by 3

Sulfotransferases

Duffel, M. W. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00005-x · Cited by 3

Androgens in male senescence

Kaufman, J., T'Sjoen, G. G., & Vermeulen, A. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9781139003353.017 · Cited by 3

In rats, oral oleoyl-DHEA is rapidly hydrolysed and converted to DHEA-sulphate

Serrano, M., Grasa, M., Fernández–Löpez, J., & Alemany, M. (2007) · BMC Pharmacology · doi:10.1186/1471-2210-7-4 · Cited by 3

Third- and Fourth-Generation SERMs

Labrie, F., Labrie, C., Bélanger, A., & Simard, J. (2002) · Humana Press eBooks · doi:10.1007/978-1-59259-157-2_9 · Cited by 3

What normal used to be: Longitudinal adrenal, reproductive, and thyroid hormone profiles from four bowhead whales during a period of Arctic stability

Jelincic, J., Dillon, D. M., Reed, J., Rogers, M. C., de Mello, D. M. D., Fleming, A. H., Lysiak, N. S. J., New, L., Buck, C. L., & Hunt, K. E. (2026) · Conservation Physiology · doi:10.1093/conphys/coag020 · Cited by 2

Physiological Shifts in Female Bowhead Whales over Historic Oceanographic and Anthropogenic Regimes

Jelincic, J., Reed, J., Rogers, M. C., New, L., Dillon, D. M., Lysiak, N. S. J., Fleming, A. H., Mello, D. E. B. F., Thacher, P., Gray, A., et al. (2026) · Integrative and Comparative Biology · doi:10.1093/icb/icag083 · Cited by 2

Sulfotransferases

Duffel, M. W. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.95623-x · Cited by 2

Chronic administration of dehydroepiandrosterone (DHEA) to female monkey and rat has no effect on mammary gland histology

Pelletier, G., Labrie, C., Martel, C., & Labrie, F. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.07.002 · Cited by 2

Hormonal Interventions of Aging and Longevity

Thakur, M. K. (2003) · Springer eBooks · doi:10.1007/978-94-017-0283-6_13 · Cited by 2

Sex Hormone and Neuroendocrine Aspects of the Metabolic Syndrome

Nawata, H., Watanabe, T., Yanase, T., Nomura, M., Ashida, K., Min, L., & Fan, W. (2010) · Progress in brain research · doi:10.1016/s0079-6123(10)82007-2 · Cited by 2

Invited Review: Selected Ergogenic Aids Used by Athletes

Steen, S. N., & Coleman, E. (1999) · Nutrition in Clinical Practice · doi:10.1177/088453369901400602 · Cited by 2

A spectrum of serum dehydroepiandrosterone and sex steroid levels in postmenopausal women

Pru, J. K. (2010) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e318200498f · Cited by 2

Chronic intake of Dioscorea esculenta suppresses testicular atrophy, enhances the ability of protection from inflammation in type 2 diabetes rats

Tatara, K., & Sato, K. (2025) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2025.106730 · Cited by 1

Stress, Well-Being, and Reproduction in Wildlife

Edwards, K. L., Brown, J. L., Edes, A. N., & Hunt, K. E. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-87707-0_3 · Cited by 1

Reproductive Puberty

Girsh, E. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108881760.003 · Cited by 1

Biomarkers of Cardiovascular Aging

Neki, N. S., Tappia, P. S., & Dhalla, N. S. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0268-2_20 · Cited by 1

Physiopathologie du déficit androgénique lié à l'âge

Shakespeare, W. (2004) · Cited by 1

Drugs and nutrition

Corrigan, B. (2000) · Journal of science and medicine in sport · doi:10.1016/s1440-2440(00)80002-x · Cited by 1

Higher premenopausal serum androgen levels and higher postmenopausal estrogen levels in women with endometrial hyperplasia

Kacalska‐Janssen, O., Rajtar-Ciosek, A., Zmaczyński, A., Milewicz, T., Bereza, T., Wiatr, J., & Krzysiek, J. (2012) · Menopause Review/Przegląd Menopauzalny · doi:10.5114/pm.2012.30245 · Cited by 1

The Cortisol/DHEA Ratio and Sexual Function in Women with and without a History of Depression

Dundon, C. M. (2014) · ScholarWorks -A service of University of Vermont Libraries (University of Vermont) · Cited by 1

Evolving concepts of depression provide new therapeutic options

Ahmed, H. H., Dayem, S. M. A. E., Foda, F., Farrag, A.-R. H., & Mohamed, H. A. E. N. (2015) · Journal of chemical and pharmaceutical research · Cited by 1

Intercellular Communication

Aykan, N. F. (1998) · Interdisciplinary applied mathematics · doi:10.1007/0-387-22706-7_7 · Cited by 1

CLINICAL AND ANALYTICAL STUDIES IN POSTMENOPAUSAL WOMEN SYMPTOMATIC OF DRY EYE

Srinivasan, S. (2008) · UWSpace (University of Waterloo)

Sexual differentiation of the brain: investigating the role of Sry using animal models

Kopsida, E. (2012) · ORCA Online Research @Cardiff (Cardiff University)

Hormones, Youth

Belkind, U. (2021) · Sage eBooks · doi:10.4135/9781544393858.n138

New development in intracrinology of breast carcinoma: therapeutic horizons after aromatase inhibitors

Sasano, H., Miki, Y., Fukuda, T., Nagasaki, S., Nakata, T., & Suzuki, T. (2007) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.2.3.367

Endokrinologie des Alters

Brückel, J. (2000) · Springer eBooks · doi:10.1007/978-3-642-59691-9_51

Síndrome metabólica. Níveis normais de DHEA protege mulheres com ovário policístico da síndrome metabólica

Dagre, A. G., Lekakis, J., Mihas, C. C., Protogerou, A. D., Thalassinou, L., Tryfonopoulos, D. J., Douridas, G., Papamichael, C. M., & Alevizaki, M. K. (2011)

Immunohistochemical evaluation of sex steroid hormones in sicca syndrome patients

Rokos, J. W. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/gz6a-k687

Chapter 10 Steroidogenesis and Neuroplasticity in the Songbird Brain

Saldanha, C. J., & Schlinger, B. A. (2008)

Synthèse de dérivés stéroïdiens et non stéroïdiens comme inhibiteurs des 17b-hydroxystéroïdes déshydrogénases type 1 et type 3

Djigoué, G. B. (2014) · Corpus Université Laval (Université Laval)

Endocrinology of Aging and Longevity

Brown‐Borg, H. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.00151-3

DHEA, The Precursor of Androgens and Estrogens in Peripheral Tissues in the Human: Intracrinology

Labrie, F., Bélanger, A., Luu-The, V., Labrie, C., Simard, J., & Lin, S. (2011) · De Gruyter eBooks · doi:10.1515/9783110811162.299

Gonadotropic axis

Hedayat, K. M., & Lapraz, J.-C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816903-2.00007-0

Dehydroepiandrosterone (DHEA) and its Role in the Aging Immune System

Khorram, O. (2011) · De Gruyter eBooks · doi:10.1515/9783110811162.57

Autopoiesis, intracrinology, and the self: toward a new model of mental health

Gordon, S. (2025) · Academia Mental Health and Well-Being · doi:10.20935/mhealthwellb7727

Clinical and Experimental Studies of Organ-Specific Autoimmune Diseases With Special Reference to Addison's Disease and Autoimmune Hepatitis

Gebre‐Medhin, G. (2001) · KTH Publication Database DiVA (KTH Royal Institute of Technology)

Effects of population density stress on fecal microbiota and metabolites of Qinghai-Tibet Plateau root voles (Microtus oeconomus)—A field experiment

Qin, Z., Guo, S., Du, S., Shang, G., Yang, L. I. U., & Yang, Y. (2026) · Global Ecology and Conservation · doi:10.1016/j.gecco.2026.e04151

Altérations du muscle squelettique humain lors du vieillissement associé ou non au syndrome métabolique et identification de nouveaux marqueurs

Gueugneau, M. (2014) · theses.fr (ABES) · doi:10.70675/aa7df51fz2d39z47d8z9b67z209b59a721b4

Contribution à l’étude des mécanismes de sensibilité aux traitements antiandrogènes dans les cancers du sein moléculaires apocrines

Grellety, T. (2018) · doi:10.70675/c8ba4d07z1e7bz4f3az969cz7ae3bff65946

Endocrine Support for the Aesthetic Patient

Parsa, A. A., & Parsa, F. D. (2026) · Springer eBooks · doi:10.1007/978-3-032-03840-1_46

BindingDB Entry 1207: First Dual Aromatase-Steroid Sulfatase Inhibitors

BindingDB (2006) · UC San Diego · doi:10.7270/q2ht2mhg

BindingDB Entry 50026118: Steroidal lactones as inhibitors of 17beta-hydroxysteroid dehydrogenase type 5: chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities.

BindingDB (2010) · UC San Diego · doi:10.7270/q2k64hwb

BindingDB Entry 50036728: Potent inhibition of steroid sulfatase activity by 3-O-sulfamate 17alpha-benzyl(or 4'-tert-butylbenzyl)estra-1,3,5(10)-trienes: combination of two substituents at positions C3 and c17alpha of estradiol.

BindingDB (2012) · UC San Diego · doi:10.7270/q2sn09m3

BindingDB Entry 50036876: Structure-activity relationships of 17alpha-derivatives of estradiol as inhibitors of steroid sulfatase.

BindingDB (2012) · UC San Diego · doi:10.7270/q2mc90qt

DHEA, The Precursor of Androgens and Estrogens in Peripheral Tissues in the Human: Intracrinology

Labrie, F., Bélanger, A., Luu-The, V., Labrie, C., Simard, J., & Lin, S. (2011) · De Gruyter eBooks · doi:10.1515/9783110811162.299

DHEA and its transformation into androgens and estrogens in peripheral target tissues: Intracrinology

Labrie, F., Luu-The, V., Labrie, C., & Simard, J. (2001) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2001.0216 · Cited by 366

DHEA and the intracrine formation of androgens and estrogens in peripheral target tissues: its role during aging

Labrie, F., Bélanger, A., Luu-The, V., Labrie, C., Simard, J., Cusan, L., Gomez, J.-L., & Candas, B. (1998) · Steroids · doi:10.1016/s0039-128x(98)00007-5 · Cited by 347

DEHYDROEPIANDROSTERONE (DHEA) AND INTRACRINOLOGY

Liben, P. (2006) · Majalah Ilmu Faal Indonesia

Intracrinology and the local enzymatic control of hormone distribution and metabolism: dehydroepiandrosterone does not just act as a prohormone for androgens and estrogens

Kühn‐Velten, W. N. (2000) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2000.0300s3034.x · Cited by 14