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DHEA and Peripheral Androgen and Estrogen Formation: Intracrinology
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“This process of peripheral cell specific activation and inactivation is known as pre- and post-receptor steroid metabolism or steroid ” intracrinology” [45,[59], [60], [61]].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [60]
In the citing paper
“the human adrenals secrete large amounts of the precursor steroids DHEA and DHEA-S, both of which are converted into androgens in target intracrine tissues (25,35,78,92,249,254,255).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [255]
In the citing paper
“the inhibition of tumor growth seen after DHEA treatment in ovariectomized animals results from its intracrine in situ conversion into androgens in the mammary gland (25,35,78,92,255).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [255]
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Metadata
- Authors
- LABRIE, F., BÉLANGER, A., SIMARD, J., LUU‐THE, V., & LABRIE, C.
- Affiliations
- Centre hospitalier de l'Université Laval (CA)
- Corresponding author
- LABRIE, FERNAND
- ORCID
- SIMARD, JACQUES
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 1995-12
- Volume
- 774
- Issue
- 1
- Pages
- 16-28
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1988520880
- Cited by
- 280
- References
- 70
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 8 · 2020: 5 · 2019: 9 · 2018: 9 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 18 · 2013: 5 · 2012: 13
- FWCI
- 7.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- dehydroepiandrosterone, intracrinology, steroid hormone metabolism, aromatase, 17β-hydroxysteroid dehydrogenase, androgen production
- MeSH terms
- Amino Acid Sequence, Androgens, Dehydroepiandrosterone, Estrogens, Humans, Hydroxysteroid Dehydrogenases, Molecular Sequence Data, NAD, NADP, RNA, Messenger, Substrate Specificity, 3-Oxo-5-alpha-Steroid 4-Dehydrogenase, 17-Hydroxysteroid Dehydrogenases, 3-Hydroxysteroid Dehydrogenases, Sequence Alignment, Alternative Splicing, Dehydroepiandrosterone Sulfate, 11-beta-Hydroxysteroid Dehydrogenases
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