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Cited by 533Stress Responses and CortisolNeuropeptides and Animal PhysiologyAdrenal Hormones and Disorders

The DOI matches its Crossref record; 70 of the 72 references it cites were found in a registry or an index.

Neuroendocrinology and Pathophysiology of the Stress System

STRATAKIS, CONSTANTINE A., CHROUSOS, GEORGE P.·1995·Annals of the New York Academy of Sciences
DOI 10.1111/j.1749-6632.1995.tb44666.x
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Abstract

The human organism is in a state of dynamic equilibrium, homeostasis. The stress system is activated when homeostasis is challenged by extrinsic or intrinsic forces, the stressors. This system, whose central component is the central nervous system (CNS) and includes corticotropin-releasing hormone (CRH) and noradrenergic neurons, respectively, in the hypothalamus and the brain stem, has as its peripheral limbs the hypothalamic-pituitary-adrenal (HPA) axis and the autonomic (sympathetic) nervous system. Normal development and preservation of life and species are dependent on a normally functioning stress system. Maladaptive neuroendocrine responses, i.e., dysregulation of the stress system, may lead to disturbances in growth and development, and cause psychiatric, endocrine/metabolic, and/or autoimmune diseases or vulnerability to such diseases.

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Crossref · 10.1111/j.1749-6632.1995.tb44666.x

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Citations

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Show all 72 references

Research works printed but not linked: 10

  1. Selye H., 1950, Stress
  2. Stratakis C. A., 1992, Greeks and Nature, the “Syndrome of Just Being Sick,” and the History of Stress in Health and Disease
  3. 10.1210/jc.78.2.249 · DOI
  4. Vanterpool J., 1991, Evidence for hypothalamic CRH deficiency in patients with seasonal affective disorder, J. Clin. Endocrinol. Metab., 72, 1382
  5. 10.1210/jc.77.5.1174 · DOI
  6. 10.1210/jc.77.2.341 · DOI · Paper page
  7. 10.1210/jc.76.3.554 · DOI
  8. Tache Y., 1994, Role of brain CRF in stress‐related alterations of gastrointestinal motor function
  9. 10.1210/en.132.3.946 · DOI
  10. 10.1210/jc.77.6.1690 · DOI · Paper page

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Metadata

Authors
STRATAKIS, C. A., & CHROUSOS, G. P.
Affiliations
National Institutes of Health (US)
ORCID
STRATAKIS, CONSTANTINE A.
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
1995-12
Volume
771
Issue
1
Pages
1-18
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1111/j.1749-6632.1995.tb44666.x
OpenAlex
W2056702525
Cited by
533
References
72
Citations by year
2026: 3 · 2025: 10 · 2024: 14 · 2023: 11 · 2022: 8 · 2021: 20 · 2020: 26 · 2019: 9 · 2018: 19 · 2017: 20 · 2016: 25 · 2015: 20 · 2014: 20 · 2013: 21 · 2012: 26
FWCI
1.64
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4034 d)
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
stress system, neuroendocrinology, homeostasis, stressors, corticotropin-releasing factor, noradrenergic neurons, hypothalamus, brainstem, hypothalamic-pituitary-adrenal axis, sympathetic nervous system, growth and development, mental illness, autoimmune disease, endocrine and metabolic diseases
MeSH terms
Affect, Animals, Digestive System Physiological Phenomena, Growth, Humans, Hypothalamus, Immunity, Metabolism, Pituitary-Adrenal System, Stress, Physiological, Thyroid Hormones

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