Apolipoprotein E, Aβ‐Amyloid, and the Molecular Pathology of Alzheimer's Disease Therapeutic Implicationsa

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

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Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

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Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

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Amyloid β-peptide is produced by cultured cells during normal metabolism

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Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

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Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

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Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

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Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

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A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid

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An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

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Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

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Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

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Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

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Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

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Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

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Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions

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Genetic associations with human longevity at the APOE and ACE loci

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A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

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Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

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Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

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Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

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Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

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Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.

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Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

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Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage.

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Processing of the amyloid protein precursor to potentially amyloidogenic derivatives.

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Expression of apolipoprotein E during nerve degeneration and regeneration.

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Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

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Isoform-specific binding of apolipoprotein E to beta-amyloid.

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Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets.

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Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro.

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Apolipoprotein E, ɛ4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region

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Hypothesis: Microtubule Instability and Paired Helical Filament Formation in the Alzheimer Disease Brain Are Related to Apolipoprotein E Genotype

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Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

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The apolipoprotein ε4 allele in patients with Alzheimer's disease

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Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3

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Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro.

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Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor

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Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation

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Protection against Alzheimer's disease with apoE ∈2

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Identification of the Alzheimer beta/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells.

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Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein.

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HUMAN APOLIPOPROTEIN MOLECULAR BIOLOGY AND GENETIC VARIATION

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[13] Isolation and characterization of apolipoprotein E

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Identification of a stable fragment of the Alzheimer amyloid precursor containing the beta-protein in brain microvessels.

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Frequency of the apolipoprotein E ε2 allele is diminished in sporadic Alzheimer disease

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Differential expression of amyloid precursor protein mRNAs in cases of Alzheimer's disease and in aged nonhuman primates

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Alzheimer's disease and soluble Aβ

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Alzheimer beta/A4 amyloid precursor protein in human brain: aging-associated increases in holoprotein and in a proteolytic fragment.

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ApoE genotypes in Australia

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Alzheimer Amyloid-β Peptide Forms Denaturant-Resistant Complex with Type ε3 but Not Type ε4 Isoform of Native Apolipoprotein E

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Apolipoprotein E allele ε4 is linked to increased deposition of the amyloid β-peptide (A-β) in cases with or without Alzheimer's disease

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Protective effect of apoE ∈2 in Alzheimer's disease

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Amyloidogenesis in Alzheimer's disease: some possible therapeutic opportunities

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Evidence for a nonsecretory, acidic degradation pathway for amyloid precursor protein in 293 cells. Identification of a novel, 22-kDa, beta-peptide-containing intermediate.

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Alzheimer β/A4‐Amyloid Precursor Protein: Evidence for Putative Amyloidogenic Fragment

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Processing of Alzheimer Aβ-Amyloid Precursor Protein: Cell Biology, Regulation, and Role in Alzheimer Disease

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Solvation Effects on the Conformational Behaviour of Gellan and Calcium Ion Binding to Gellan Double Helices

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APP processing, Aβ-amyloidogenesis, and the pathogenesis of Alzheimer's disease

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Proteolytic processing of human amyloid beta protein precursor in insect cells. Major carboxyl-terminal fragment is identical to its human counterpart.

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AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease

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Pitfalls in the quantitative estimation of β-amyloid immunoreactivity in human brain tissue

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Fibrillar and Oligomeric β‐Amyloid as Distinct Local Biomarkers for Alzheimer's Disease

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Dicyanovinyl-substituted J147 analogue inhibits oligomerization and fibrillation of β-amyloid peptides and protects neuronal cells fromβ-amyloid-induced cytotoxicity

정유훈, 김경도, 추현아, et al. (2015)

Aromadendrin: a dual amyloid promoter to accelerate fibrillization and reduce cytotoxicity of both amyloid-β and hIAPP

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Method to discriminate amyloids using fluorescent probes

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