Are there oxytocin receptors in the primate brain?
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The limited information on distributions of OTR and V1aR in primate neural tissue is due in part to lower selectivity of radioligands for OTR and V1aR autoradiography in primates relative to rodents, and promiscuous binding profiles of both radioligands.
“The limited information on the distributions of OTR and V1aR in primate neural tissue is due in part to the lower selectivity for radioligands targeting OTR (125I-OVTA) and V1aR (125I-LVA) autoradiography, relative to high selectivity of radioligands for these receptors in rodents, as well as the promiscuous binding profile of both radioligands for OTR and V1aR (Freeman et al., 2014a, 2014b; Man”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Toloczko et al., 1997
Cites
Tyr115 is the key residue for determining agonist selectivity in the V1a vasopressin receptor
Chini, B., Mouillac, B., Ala, Y., Balestre, M. N., Trumpp‐Kallmeyer, S., Hoflack, J., Elands, J., Hibert, M., Manning, M., & Jard, S. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07211.x · Cited by 179 · see citing works
Vasopressin and oxytocin systems in the brain and upper spinal cord of <i>Macaca fascicularis</i>
Caffé, A. R., Van Ryen, P. C., Van Der Woude, T. P., & Van Leeuwen, F. W. (1989) · Journal of Comparative Neurology · doi:10.1002/cne.902870304 · Cited by 128 · see citing works
Elands, J., Beetsma, A. L., Barberis, C., & de Kloet, E. R. (1988) · PubMed · Cited by 121 · see citing works
Barberis, C., Balestre, M., Jard, S., Tribollet, E., Arsenijévic, Y., Dreifuss, J. J., Bańkowski, K., Manning, M., Chan, W. Y., Schlosser, S. S., et al. (2008) · Neuroendocrinology · doi:10.1159/000126998 · Cited by 95 · see citing works
Labelling of vasopressin and oxytocin receptors from the human uterus
Tencé, M., Guillon, G., Bottari, S. P., & Jard, S. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)94177-y · Cited by 28 · see citing works
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Oxytocin, motherhood and bonding
Kendrick, K. M. (2000) · Experimental Physiology · doi:10.1111/j.1469-445x.2000.tb00014.x · Cited by 378 · see citing works
Immunohistochemical localization of oxytocin receptors in human brain
Boccia, M. L., Petrusz, P., Suzuki, K., Marson, L., & Pedersen, C. A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.048 · Cited by 276 · see citing works
Freeman, S. M., & Young, L. J. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12382 · Cited by 196 · see citing works
“The mapping of OXTR in the macaque brain was previously attempted in the 1990s but abandoned because of the apparent nonselectivity of 125I-OVTA (34).”
BackgroundSelf-citationFreeman, S. M., Inoue, K., Smith, A. L., Goodman, M. M., & Young, L. J. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.03.023 · Cited by 185 · see citing works
“2), which is consistent with what was previously reported for these radioligands in this species (Toloczko et al., 1997; Young et al., 1999).”
BackgroundResultFreeman, S. M., Walum, H., Inoue, K., Smith, A. L., Goodman, M. M., Bales, K. L., & Young, L. J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.055 · Cited by 153 · see citing works
Self-citationBoccia, M. L., Goursaud, A.-P. S., Bachevalier, J., Anderson, K. D., & Pedersen, C. A. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.05.009 · Cited by 136 · see citing works
Oxytocin reduces alcohol cue-reactivity in alcohol-dependent rats and humans
Hansson, A. C., Koopmann, A., Uhrig, S., Bühler, S., Domi, E., Kiessling, E., Ciccocioppo, R., Froemke, R. C., Grinevich, V., Kiefer, F., et al. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.257 · Cited by 109 · see citing works
Intranasal oxytocin effects on social cognition: A critique
Evans, S. L., Dal Monte, O., Noble, P., & Averbeck, B. B. (2014) · Brain Research · doi:10.1016/j.brainres.2013.11.008 · Cited by 97 · see citing works
Wang, Z., Toloczko, D., Young, L. J., Moody, K., Newman, J. D., & Insel, T. R. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00636-7 · Cited by 75 · see citing works
Self-citationNeuropeptide diversity and the regulation of social behavior in New World primates
French, J. A., Taylor, J. H., Mustoe, A. C., & Cavanaugh, J. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.03.004 · Cited by 66 · see citing works
Smith, A. L., Freeman, S. M., Voll, R. J., Young, L. J., & Goodman, M. M. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.10.116 · Cited by 38 · see citing works
Self-citationSmith, A. L., Freeman, S. M., Stehouwer, J. S., Inoue, K., Voll, R. J., Young, L. J., & Goodman, M. M. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.02.019 · Cited by 35 · see citing works
Self-citationBridging the gap between rodents and humans: The role of non‐human primates in oxytocin research
Putnam, P. T., Young, L. J., & Gothard, K. M. (2018) · American Journal of Primatology · doi:10.1002/ajp.22756 · Cited by 28 · see citing works
“Early attempts to localize OXTRs in NHPs were inconclusive (Toloczko, Young, & Insel, 1997) due to the cross-reactivity of the OT radioligand used for OXTR autoradiography and structurally similar arginine vasopressin receptor (AVPR1A) (Manning et al., 2012).”
BackgroundSelf-citationInvestigation of an F-18 oxytocin receptor selective ligand via PET imaging
Smith, A. L., Freeman, S. M., Voll, R. J., Young, L. J., & Goodman, M. M. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.07.045 · Cited by 28 · see citing works
Self-citation
- Authors
- TOLOCZKO, D. M., YOUNG, L., & INSEL, T. R.
- Affiliations
- Emory University (US)
- Corresponding author
- INSEL, T. R.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 1997-01
- Volume
- 807
- Issue
- 1
- Pages
- 506-509
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2025378317
- Cited by
- 33
- References
- 5
- Citations by year
- 2023: 1 · 2022: 1 · 2020: 1 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 2
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin receptor, primate brain, oxytocin, neuropeptides, receptor localization
- MeSH terms
- Animals, Autoradiography, Brain, Iodine Radioisotopes, Macaca mulatta, Radioligand Assay, Polymerase Chain Reaction, Receptors, Vasopressin, Receptors, Oxytocin
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