Oxytocin reduces alcohol cue-reactivity in alcohol-dependent rats and humans
Open accessAbstract
Approved pharmacological treatments for alcohol use disorder are limited in their effectiveness, and new drugs that can easily be translated into the clinic are warranted. One of those candidates is oxytocin because of its interaction with several alcohol-induced effects. Alcohol-dependent rats as well as post-mortem brains of human alcoholics and controls were analyzed for the expression of the oxytocin system by qRT-PCR, in situ hybridization, receptor autoradiography ([125 I]OVTA binding), and immunohistochemistry. Alcohol self-administration and cue-induced reinstatement behavior was measured after intracerebroventricular injection of 10 nM oxytocin in dependent rats. Here we show a pronounced upregulation of oxytocin receptors in brain tissues of alcohol-dependent rats and deceased alcoholics, primarily in frontal and striatal areas. This upregulation stems most likely from reduced oxytocin expression in hypothalamic nuclei. Pharmacological validation showed that oxytocin reduced cue-induced reinstatement response in dependent rats-an effect that was not observed in non-dependent rats. Finally, a clinical pilot study (German clinical trial number DRKS00009253) using functional magnetic resonance imaging in heavy social male drinkers showed that intranasal oxytocin (24 IU) decreased neural cue-reactivity in brain networks similar to those detected in dependent rats and humans with increased oxytocin receptor expression. These studies suggest that oxytocin might be used as an anticraving medication and thus may positively affect treatment outcomes in alcoholics.
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Oxytocin reduces cue-induced reinstatement in dependent rats but not in nondependent rats.
“Oxytocin also reduced cue-induced reinstatement in dependent rats but not in nondependent rats (Hansson et al., 2018).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Hansson et al., 2018
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King, C. E., & Becker, H. C. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05233-z · Cited by 53 · see citing works
Off-label and investigational drugs in the treatment of alcohol use disorder: A critical review
Fischler, P. V., Soyka, M., Seifritz, E., & Mutschler, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.927703 · Cited by 34 · see citing works
- Authors
- Hansson, A. C., Koopmann, A., Uhrig, S., Bühler, S., Domi, E., Kiessling, E., Ciccocioppo, R., Froemke, R. C., Grinevich, V., Kiefer, F., Sommer, W. H., Vollstädt-Klein, S., & Spanagel, R.
- Affiliations
- Heidelberg University (DE)
- Università di Camerino (IT)
- New York University (US)
- German Cancer Research Center (DE)
- Corresponding author
- Hansson, Anita C
- ORCID
- Venue
- Neuropsychopharmacology
- Published
- 2017-11-01
- Volume
- 43
- Issue
- 6
- Pages
- 1235-1246
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC5916348
- OpenAlex
- W2767028581
- Cited by
- 109
- References
- 87
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 11 · 2023: 9 · 2022: 19 · 2021: 21 · 2020: 18 · 2019: 9 · 2018: 10
- FWCI
- 14.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Unicam Scientific Publications (University of Camerino) (submittedVersion, other-oa)
- Funders
- European Commission (668863)
- Deutsche Forschungsgemeinschaft (DFG HA6102/1, DFG HA6102/1-1, SFB1134, HA6102/1-1)
- Bundesministerium für Bildung und Forschung (FKZ: 01ZX1311A, 01ZX1311A)
- National Institute on Alcohol Abuse and Alcoholism (R28AA012725)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- oxytocin, alcoholism, alcohol cue reactivity, cue-induced reinstatement, alcohol self-administration, intranasal oxytocin, craving, social drinkers, striatum, frontal cortex
- MeSH terms
- Administration, Intranasal, Alcohol Deterrents, Alcoholism, Animals, Brain, Cues, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Oxytocin, Pilot Projects, RNA, Messenger, Rats, Wistar, Receptors, Oxytocin, Craving
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