The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Sleep: A Physiologic Role for IL‐1β and TNF‐αa
Abstract
ABSTRACT: Interleukin‐1β (IL‐1β) and tumor necrosis factor‐α (TNF‐α) are involved in physiologic sleep regulation. Administration of exogenous IL‐1β or TNF‐α induces increased non‐rapid eye movement sleep (NREMS). Inhibition of IL‐1 or TNF reduces spontaneous sleep. There is a diurnal rhythm of TNF‐α mRNA and IL‐1β mRNA in brain with highest levels occurring during peak sleep periods. Mice lacking either the TNF 55‐kD receptor or the IL‐1 type I receptor sleep less than do strain controls. IL‐1β and TNF‐α are part of a larger biochemical cascade involved in sleep regulation; other somnogenic substances in this cascade include growth hormone‐releasing hormone and nitric oxide. Several additional substances are involved in inhibitory feedback mechanisms, some of which inhibit IL‐1 and TNF. A major challenge to sleep research is to define how and where these molecular steps produce sleep.
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Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Kales, A., Tyson, K., & Chrousos, G. P. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.5.3950 · Cited by 974
Endogenous sleep-promoting substances and sleep regulation
Borbely, A. A., & Tobler, I. (1989) · Physiological Reviews · doi:10.1152/physrev.1989.69.2.605 · Cited by 259
Interleukin 1 alters rat sleep: temporal and dose-related effects
Opp, M. R., Obal, F., & Krueger, J. M. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.260.1.r52 · Cited by 232
Self-citationMice Lacking the TNF 55 kDa Receptor Fail to Sleep More After TNFα Treatment
Fang, J., Wang, Y., & Krueger, J. M. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-15-05949.1997 · Cited by 167
Self-citationEffects of Sleep on the Production of Cytokines in Humans
Uthgenannt, D., Schoolmann, D., Pietrowsky, R., Fehm, H.-L., & Born, J. (1995) · Psychosomatic Medicine · doi:10.1097/00006842-199503000-00001 · Cited by 112
Cited by
The olfactory bulbectomised rat as a model of depression
Song, C., & Leonard, B. E. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.010 · Cited by 698
Cytokines and cognition–the case for a head-to-toe inflammatory paradigm.
Wilson, C. J., Finch, C. E., & Cohen, H. J. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50619.x · Cited by 637
“Inflammatory” Cytokines: Neuromodulators in Normal Brain?
Vitkovic, L., Bockaert, J., & Jacque, C. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.740457.x · Cited by 506
Shearer, W. T., Reuben, J. M., Mullington, J. M., Price, N. J., Lee, B.-N., Smith, E. O., Szuba, M. P., Van Dongen, H. P. A., & Dinges, D. F. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.112270 · Cited by 455
Neuromodulation by the immune system: a focus on cytokines
Salvador, A. F., de Lima, K. A., & Kipnis, J. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00508-z · Cited by 389
Metadata
- Authors
- KRUEGER, J. M., FANG, J., TAISHI, P., CHEN, Z., KUSHIKATA, T., & GARDI, J.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 1998-09
- Volume
- 856
- Issue
- 1
- Pages
- 148-159
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1563952748
- Cited by
- 198
- References
- 5
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- KRUEGER, J. M., FANG, J., TAISHI, P., CHEN, Z., KUSHIKATA, T., & GARDI, J. (1998). Sleep: A Physiologic Role for IL‐1β and TNF‐αa. Annals of the New York Academy of Sciences. https://doi.org/10.1111/j.1749-6632.1998.tb08323.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
