Sex Hormones Modulate Inflammatory Mediators Produced by Macrophages a
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Testosterone bound to androgen receptors can downregulate synthesis of proinflammatory cytokines and stimulate secretion of anti-inflammatory cytokines.
“When bound to androgen receptors, testosterone can downregulate synthesis of proinflammatory cytokines (D’Agostino et al., 1999; Li et al., 1993; Trigunaite et al., 2015), and stimulate secretion of anti-inflammatory cytokines (Liva and Voskuhl, 2001).”
From Developmental psychoneuroendocrine and psychoneuroimmune pathways from childhood adversity to disease (2017) · cites this paper as D’Agostino et al., 1999
In cell culture studies testosterone reduces expression of pro-inflammatory cytokines such as TNFa, interleukin 1, and interleukin 6 in human vascular endothelium, monocytes, and fibroblasts.
“In cell culture studies testosterone has been found to reduce the expression of pro-inflammatory cytokines such as TNFa, interleukin 1, and interleukin 6 in human vascular endothelium, monocytes, and fibroblasts.[36][37][38][39]”
From Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life (2004) · cites this paper as [37]
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Estriol: A potent regulator of TNF and IL-6 expression in a murine model of endotoxemia
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Estrogen receptor β — Getting in on the action?
Gustafsson, J.-Å. (1997) · Nature Medicine · doi:10.1038/nm0597-493 · Cited by 48 · see citing works
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Self-citationSex Hormones as Immunomodulators of Disease
Lahita, R. G. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb35876.x · Cited by 29 · see citing works
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Sex differences in immune responses
Klein, S. L., & Flanagan, K. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.90 · Cited by 6,370 · see citing works
Malkin, C. J., Pugh, P. J., Jones, R. D., Kapoor, D., Channer, K. S., & Jones, T. H. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031069 · Cited by 731 · see citing works
Sex differences in neuroimmunity and pain
Rosen, S., Ham, B., & Mogil, J. S. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23831 · Cited by 318 · see citing works
Malkin, C. J., Pugh, P. J., Morris, P. D., Kerry, K. E., Jones, R. D., Jones, T. H., & Channer, K. S. (2004) · Heart · doi:10.1136/hrt.2003.021121 · Cited by 250 · see citing works
Mechanisms of sex disparities in influenza pathogenesis
Klein, S. L., Hodgson, A., & Robinson, D. P. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0811427 · Cited by 219 · see citing works
Kuhlman, K. R., Chiang, J. J., Horn, S., & Bower, J. E. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.020 · Cited by 208 · see citing works
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Nutritional interventions for cancer-induced cachexia
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Let’s talk about sex characteristics—as a risk factor for invasive fungal diseases.
Egger, M., Hoenigl, M., Thompson, G. R., Carvalho, A., & Jenks, J. D. (2022) · Mycoses · doi:10.1111/myc.13449 · Cited by 82 · see citing works
RISING STARS: androgens and immune cell function
Ainslie, R. J., Simitsidellis, I., Kirkwood, P. M., & Gibson, D. A. (2024) · Journal of Endocrinology · doi:10.1530/joe-23-0398 · Cited by 48 · see citing works
Howard, E. E., Margolis, L. M., Berryman, C. E., Lieberman, H. R., Karl, J. P., Young, A. J., Montano, M. A., Evans, W. J., Rodriguez, N. R., Johannsen, N. M., et al. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00157.2020 · Cited by 28 · see citing works
- Authors
- D'AGOSTINO, P., MILANO, S., BARBERA, C., DI BELLA, G., LA ROSA, M., FERLAZZO, V., FARRUGGIO, R., MICELI, D. M., MIELE, M., CASTAGNETTA, L., & CILLARI, E.
- Affiliations
- University of Palermo (IT)
- Corresponding author
- CILLARI, E.
- ORCID
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 1999-06
- Volume
- 876
- Issue
- 1
- Pages
- 426-429
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2154865730
- Cited by
- 262
- References
- 6
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 14 · 2023: 19 · 2022: 20 · 2021: 19 · 2020: 13 · 2019: 8 · 2018: 16 · 2017: 10 · 2016: 11 · 2015: 7 · 2014: 8 · 2013: 12 · 2012: 5
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- sex hormones, macrophages, inflammatory mediators, inflammation, sex differences
- MeSH terms
- Animals, Cell Line, Estradiol, Lipopolysaccharides, Macrophages, Nitric Oxide, Receptors, Androgen, Receptors, Estradiol, Testosterone, Tumor Necrosis Factor-alpha, Interleukin-10, Inflammation Mediators
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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