Correlation between Testosterone and the Inflammatory Marker Soluble Interleukin-6 Receptor in Older Men
Abstract
CONTEXT: An age-associated decline in testosterone (T) levels and an increase in proinflammatory cytokines contribute to chronic diseases in older men. Whether and how these changes are related is unclear. OBJECTIVE: We hypothesized that T and inflammatory markers are negatively correlated in older men. DESIGN: This was a cross-sectional study. SETTING: A population-based sample of older men was studied. PARTICIPANTS AND MEASURES: After excluding participants taking glucocorticoids or antibiotics or those with recent hospitalization, 467 men, aged 65 yr or older, had complete determinations of total T, bioavailable T, SHBG, albumin, IL-6, soluble IL-6 receptor (sIL-6r), TNF-alpha, IL-1beta, and C-reactive protein. RESULTS: After adjusting for potential confounders, sIL-6r was significantly and inversely correlated with total T (r = -0.20; P < 0.001) and bioavailable T (r = -0.12; P < 0.05). T was not correlated with any other inflammatory marker. CONCLUSIONS: These preliminary findings suggest an inverse relationship between T and sIL-6r. Longitudinal studies are needed to establish the causality of this association.
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Low sex hormone levels are associated with inflammation.
“Low sex hormone levels are associated with inflammation (62).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [62]
A variety of phenomena have been proposed to contribute to the age-related heightened inflammatory state, including redox stress, immuno- and endocrine senescence, DNA damage, epigenetic modification, and a distortion of gut microbial homeostasis associated with increased levels of circulating endotoxin.
“A variety of phenomena have been proposed to contribute to this age-related heightened inflammatory state including redox stress [46], immuno- and endocrine senescence [47, 48], DNA damage [49], epigenetic modification [50], and a distortion of gut microbial homeostasis [51] that is associated with increased levels of circulating endotoxin [42].”
From Gut Microbiota Contribute to Age-Related Changes in Skeletal Muscle Size, Composition, and Function: Biological Basis for a Gut-Muscle Axis (2018) · cites this paper as [48]
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- Authors
- Maggio, M., Basaria, S., Ble, A., Lauretani, F., Bandinelli, S., Ceda, G. P., Valenti, G., Ling, S. M., & Ferrucci, L.
- Affiliations
- National Institutes of Health (US)
- Azienda Sanitaria di Firenze (IT)
- University of Parma (IT)
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2006-01
- Volume
- 91
- Issue
- 1
- Pages
- 345-347
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2070468050
- Cited by
- 200
- References
- 20
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 7 · 2023: 7 · 2022: 9 · 2021: 10 · 2020: 13 · 2019: 10 · 2018: 9 · 2017: 11 · 2016: 5 · 2015: 12 · 2014: 16 · 2013: 13 · 2012: 17
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Minority Health and Health Disparities (263-MD-916413, 263MD 821336)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- testosterone, soluble IL-6 receptor, inflammation, older men, aging, bioavailable testosterone, sex hormone-binding globulin, inflammatory cytokines, C-reactive protein, TNF-α, IL-1β, age-related testosterone decline
- MeSH terms
- Aged, Aged, 80 and over, Aging, C-Reactive Protein, Humans, Interleukin-1, Italy, Male, Testosterone, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Cytokines, Inflammation Mediators, Receptors, Interleukin-6
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