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Cited by 339

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells

Open access
Shay-Salit, Ayelet, Shushy, Moran, Wolfovitz, Efrat, Yahav, Hava, Breviario, Ferruccio, Dejana, Elisabetta, Resnick, Nitzan·2002·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.142224299
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Abstract

Blood-flow interactions with the vascular endothelium represents a specialized example of mechanical regulation of cell function that has important physiological and pathophysiological cardiovascular consequences. Yet, the mechanisms of mechanostransduction are not understood fully. This study shows that shear stress induces a rapid induction as well as nuclear translocation of the vascular endothelial growth factor (VEGF) receptor 2 and promotes the binding of the VEGF receptor 2 and the adherens junction molecules, VE-cadherin and β-catenin, to the endothelial cytoskeleton. These changes are accompanied by the formation of a complex containing the VEGF receptor 2–VE-cadherin–β-catenin. In endothelial cells lacking VE-cadherin, shear stress did not augment nuclear translocation of the VEGF receptor 2 and phosphorylation of Akt1 and P38 as well as transcriptional induction of a reporter gene regulated by a shear stress-responsive promoter. These results suggest that VEGF receptor 2 and the adherens junction act as shear-stress cotransducers, mediating the transduction of shear-stress signals into vascular endothelial cells.

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Metadata

Authors
Shay-Salit, A., Shushy, M., Wolfovitz, E., Yahav, H., Breviario, F., Dejana, E., & Resnick, N.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2002-06-21
Volume
99
Issue
14
Pages
9462-9467
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.142224299
OpenAlex
W2105998706
Cited by
339
References
41
FWCI
6.37
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells. https://app.cochat.ai/papers/10.1073/pnas.142224299
The paper
Shay-Salit, A., Shushy, M., Wolfovitz, E., Yahav, H., Breviario, F., Dejana, E., & Resnick, N. (2002). VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.142224299

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.