Functional nicotinic acetylcholine receptor expression on stem and progenitor cells of the early embryonic nervous system
Abstract
Although the adult brain contains nicotinic acetylcholine (ACh) receptors vital to cortical function, little is known about the assembly of embryonic receptor subunits into functional receptors or their role in fetal brain development. We now report the first evidence of functional nicotinic ACh receptors on stem and progenitor cells of fetal mouse cerebral cortex as early as embryonic day 10.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Early activation or desensitization of nAChRs by nicotine can cause long-term developmental disruption.
“Since nAChRs are functional at early stages of brain development, their early activation and/or desensitization by nicotine can lead to long-term developmental disruption.”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [50]
Cites
Neurotransmitters as growth regulatory signals: role of receptors and second messengers
Lauder, J. M. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90162-f · Cited by 806 · see citing works
Neurotransmitter regulation of neuronal outgrowth, plasticity and survival
Lipton, S. A., & Kater, S. B. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90026-x · Cited by 724 · see citing works
Fetal Nicotine or Cocaine Exposure: Which One is Worse?
Slotkin, T. A. (1998) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37495-6 · Cited by 676 · see citing works
Effect of Maternal Cigarette Smoking on Pregnancy Complications and Sudden Infant Death Syndrome
DiFranza, J. R., & Lew, R. (1995) · European Journal of General Practice · doi:10.3109/13814789509160303 · Cited by 354 · see citing works
Nicotinic Receptor-Induced Apoptotic Cell Death of Hippocampal Progenitor Cells
Berger, F. R., Gage, F. H., & Vijayaraghavan, S. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-17-06871.1998 · Cited by 233 · see citing works
Atluri, P., Fleck, M. W., Shen, Q., Mah, S. J., Stadfelt, D., Barnes, W., Goderie, S. K., Temple, S., & Schneider, A. S. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0453 · Cited by 110 · see citing works
Self-citationACETYLCHOLINE SYSTEM AND NEURAL DEVELOPMENT
Filogamo, G., & Marchisio, P. C. (1971) · Elsevier eBooks · doi:10.1016/b978-0-12-512504-8.50008-1 · Cited by 108 · see citing works
Nieburg, P. I., Marks, J. S., McLaren, N. M., et al. (1985) · PubMed · Cited by 69 · see citing works
Nieburg, P. I. (1985) · JAMA · doi:10.1001/jama.1985.03350440076035 · Cited by 53 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Slotkin, T. A. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.06.001 · Cited by 544 · see citing works
Slotkin, T. A. (2008) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2007.09.002 · Cited by 206 · see citing works
Moylan, S., Jacka, F. N., Pasco, J. A., & Berk, M. (2013) · Brain and Behavior · doi:10.1002/brb3.137 · Cited by 186 · see citing works
England, L. J., Aagaard, K., Bloch, M., Conway, K., Cosgrove, K., Grana, R., Gould, T. J., Hatsukami, D., Jensen, F., Kandel, D., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.013 · Cited by 181 · see citing works
Neuroimaging of children following prenatal drug exposure
Derauf, C., Kekatpure, M., Neyzi, N., Lester, B., & Kosofsky, B. (2009) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2009.03.001 · Cited by 122 · see citing works
McNair, L. F., & Kohlmeier, K. A. (2015) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174414000439 · Cited by 22 · see citing works
- Authors
- SCHNEIDER, A. S., ATLURI, P., SHEN, Q., BARNES, W., MAH, S. J., STADFELT, D., GODERIE, S. K., TEMPLE, S., & FLECK, M. W.
- Affiliations
- Albany Medical College (US)
- Corresponding author
- SCHNEIDER, A. S.
- ORCID
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2002-10
- Volume
- 971
- Issue
- 1
- Pages
- 135-138
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2049503548
- Cited by
- 29
- References
- 9
- Citations by year
- 2021: 1 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r03hd039808-02)
- National Institute of Neurological Disorders and Stroke (R01 NS 33529, R01NS033529)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R03-HD39808)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nicotinic acetylcholine receptors, embryonic nervous system, neural stem cells, neural progenitor cells, fetal cerebral cortex, receptor subunit assembly, fetal brain development, mouse embryo
- MeSH terms
- Animals, Brain, Calcium, Cell Differentiation, Cerebral Cortex, Electrophysiology, Receptors, Nicotinic, Stem Cells, Time Factors, Mice, alpha7 Nicotinic Acetylcholine Receptor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
