The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Humoral Links between Sleep and the Immune System: Research Issues
Abstract
A bstract: In the last twenty years we have realized that the immune system synthesizes a class of peptides, termed cytokines, that play a central role in alerting the brain to ongoing inflammation in peripheral tissues. Among the brain's responses to proinflammatory cytokines, or agents that induce these cytokines, are certain alterations in sleep profiles. Characteristically there is an increase in non‐rapid eye movement sleep (NREMS), and NREMS intensity is often accompanied by a decrease in rapid eye movement sleep (REMS). Cytokines appear to play a role in normal sleep regulation; during pathology, higher levels of cytokines amplify the physiological cytokine sleep mechanisms. In this review we summarize the extensive literature on the roles of interleukin‐1 (IL‐1) and tumor necrosis factor‐α (TNF‐α) in sleep regulation, and their interactions with the neuropeptides growth hormone‐releasing hormone (GHRH) and corticotropin‐releasing hormone (CRH). We reach the tentative conclusion that the sleep‐promoting actions of IL‐1 and GHRH are mediated via anterior hypothalamic neurons that are receptive to these substances. It also seems likely that TNF‐α and CRH also influence these neurons. In addition, we discuss an array of research issues raised by these studies that remain to be resolved.
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Cites
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“Inflammatory” Cytokines: Neuromodulators in Normal Brain?
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Biochemical regulation of non-rapid-eye-movement sleep
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Self-citationInterleukin 1 alters rat sleep: temporal and dose-related effects
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Self-citationMicrobial Products and Cytokines in Sleep and Fever Regulation
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Self-citationTumor necrosis factor receptor fragment attenuates interferon-γ-induced non-REM sleep in rabbits
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Cited by
The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479
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Neuropathogenesis of Delirium: Review of Current Etiologic Theories and Common Pathways
Maldonado, J. R. (2013) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.09.005 · Cited by 745
Haack, M., Sanchez, E., & Mullington, J. M. (2007) · Sleep · doi:10.1093/sleep/30.9.1145 · Cited by 615
Sick and tired: does sleep have a vital role in the immune system?
Bryant, P. A., Trinder, J., & Curtis, N. (2004) · Nature Reviews Immunology · doi:10.1038/nri1369 · Cited by 551
Metadata
- Authors
- KRUEGER, J. M., & MAJDE, J. A.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2003-05
- Volume
- 992
- Issue
- 1
- Pages
- 9-20
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1963992117
- Cited by
- 161
- References
- 7
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- KRUEGER, J. M., & MAJDE, J. A. (2003). Humoral Links between Sleep and the Immune System: Research Issues. Annals of the New York Academy of Sciences. https://doi.org/10.1111/j.1749-6632.2003.tb03133.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
