The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Cooperation of β2‐ and β3‐adrenergic receptors in hematopoietic progenitor cell mobilization
Open accessAbstract
CXCL12/SDF‐1 dynamically regulates hematopoietic stem cell (HSC) attraction in the bone marrow (BM). Circadian regulation of bone formation and HSC traffic is relayed in bone and BM by β‐adrenergic receptors (β‐AR) expressed on HSCs, osteoblasts, and mesenchymal stem/progenitor cells. Circadian HSC release from the BM follows rhythmic secretion of norepinephrine from nerve terminals, β 3‐AR activation, and Cxcl12 downregulation, possibly from reduced Sp1 nuclear content. Here, we show that β‐AR stimulation in stromal cells causes Sp1 degradation, partially mediated by the 26S proteasome. Inverted trends of circulating hematopoietic progenitors and BM Cxcl12 mRNA levels change acutely after light onset, shown to induce sympathetic efferent activity. In BM stromal cells, activation of β 3‐AR downregulates Cxcl12, whereas β 2‐AR stimulation induces clock gene expression. Double deficiency in β 2‐ and β 3‐ARs compromises enforced mobilization. Therefore, β 2‐ and β 3‐ARs have specific roles in stromal cells and cooperate during progenitor mobilization.
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Cites
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379
Leptin regulation of bone resorption by the sympathetic nervous system and CART
Elefteriou, F., Ahn, J. D., Takeda, S., Starbuck, M., Yang, X., Liu, X., Kondo, H., Richards, W. G., Bannon, T. W., Noda, M., et al. (2005) · Nature · doi:10.1038/nature03398 · Cited by 1,311
Overflow of catecholamine neurotransmitters to the circulation: source, fate, and functions
Esler, M., Jennings, G., Lambert, G., Meredith, I., Horne, M., & Eisenhofer, G. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.4.963 · Cited by 794
Cited by
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
Méndez-Ferrer, S., Michurina, T. V., Ferraro, F., Mazloom, A. R., MacArthur, B. D., Lira, S. A., Scadden, D. T., Ma’ayan, A., Enikolopov, G. N., & Frenette, P. S. (2010) · Nature · doi:10.1038/nature09262 · Cited by 3,374
Self-citationChow, A., Lucas, D., Hidalgo, A., Méndez-Ferrer, S., Hashimoto, D., Scheiermann, C., Battista, M., Leboeuf, M., Prophete, C., van Rooijen, N., et al. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20101688 · Cited by 864
Self-citationWinkler, I. G., Sims, N. A., Pettit, A. R., Barbier, V., Nowlan, B., Helwani, F., Poulton, I. J., van Rooijen, N., Alexander, K. A., Raggatt, L. J., et al. (2010) · Blood · doi:10.1182/blood-2009-11-253534 · Cited by 801
Sympathetic nervous system regulation of the tumour microenvironment
Cole, S. W., Nagaraja, A. S., Lutgendorf, S. K., Green, P. A., & Sood, A. K. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3978 · Cited by 576
Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche
Maryanovich, M., Zahalka, A. H., Pierce, H., Pinho, S., Nakahara, F., Asada, N., Wei, Q., Wang, X., Ciero, P., Xu, J., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0030-x · Cited by 389
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Metadata
- Authors
- Méndez‐Ferrer, S., Battista, M., & Frenette, P. S.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2010-04
- Volume
- 1192
- Issue
- 1
- Pages
- 139-144
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2112703508
- Cited by
- 194
- References
- 3
- FWCI
- 6.46
- Type
- journal article
- Language
- en
- Open access
- green
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- Méndez‐Ferrer, S., Battista, M., & Frenette, P. S. (2010). Cooperation of β2‐ and β3‐adrenergic receptors in hematopoietic progenitor cell mobilization. Annals of the New York Academy of Sciences. https://doi.org/10.1111/j.1749-6632.2010.05390.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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