The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Dynamic regulation of mitochondrial fission through modification of the dynamin‐related protein Drp1
Open accessAbstract
Mitochondria in cells comprise a tubulovesicular network shaped continuously by complementary fission and fusion events. The mammalian Drp1 protein plays a key role in fission, while Mfn1, Mfn2, and OPA1 are required for fusion. Shifts in the balance between these opposing processes can occur rapidly, indicating that modifications to these proteins may regulate mitochondrial membrane dynamics. We highlight posttranslational modifications of the mitochondrial fission protein Drp1, for which these regulatory mechanisms are best characterized. This dynamin‐related GTPase undergoes a number of steps to mediate mitochondrial fission, including translocation from cytoplasm to the mitochondrial outer membrane, higher‐order assembly into spirals, GTP hydrolysis associated with a conformational change and membrane deformation, and ultimately disassembly. Many of these steps may be influenced by covalent modification of Drp1. We discuss the dynamic nature of Drp1 modifications and how they contribute not only to the normal regulation of mitochondrial division, but also to neuropathologic processes.
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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
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Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A
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Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission.
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Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria
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Self-citationS-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury
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A Lethal Defect of Mitochondrial and Peroxisomal Fission
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Metadata
- Authors
- Chang, C., & Blackstone, C.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2010-07
- Volume
- 1201
- Issue
- 1
- Pages
- 34-39
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1778352924
- Cited by
- 567
- References
- 8
- FWCI
- 9.33
- Type
- journal article
- Language
- en
- Open access
- green
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- Chang, C., & Blackstone, C. (2010). Dynamic regulation of mitochondrial fission through modification of the dynamin‐related protein Drp1. Annals of the New York Academy of Sciences. https://doi.org/10.1111/j.1749-6632.2010.05629.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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