The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Resveratrol and cellular mechanisms of cancer prevention
Abstract
The use of novel and improved chemopreventive and chemotherapeutic agents for the prevention and treatment of cancer is on the rise. Natural products have always afforded a rich source of such agents. Epidemiological evidence suggests that a higher flavonoid intake is associated with low cancer risk. Accumulating data clearly indicate that the induction of apoptosis is an important component in the chemoprevention of cancer by naturally occurring dietary agents. Resveratrol, a naturally occurring polyphenol, demonstrates pleiotropic health benefits, including antioxidant, anti‐inflammatory, antiaging, cardioprotective, and neuroprotective activities. Because of these properties and their wide distribution throughout the plant kingdom, resveratrol is envisioned as a potential chemopreventive/curative agent. Currently, a number of preclinical findings from our lab and elsewhere suggest resveratrol to be a promising natural weapon in the war against cancer. Remarkable progress in elucidating the molecular mechanisms underlying the anticancer properties of resveratrol has been achieved. Here, we focus on some of the myriad pathways that resveratrol targets to exert its chemopreventive role and advocate that resveratrol holds tremendous potential as an efficient anticancer drug of the future.
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Therapeutic potential of resveratrol: the in vivo evidence
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To be, or not to be: NF-κB is the answer – role of Rel/NF-κB in the regulation of apoptosis
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Regulation of SIRT1 in cellular functions: Role of polyphenols
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Cancer Prevention With Natural Compounds
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Cited by
Resveratrol and health—A comprehensive review of human clinical trials
Smoliga, J. M., Baur, J. A., & Hausenblas, H. A. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100143 · Cited by 594
Resveratrol and cancer: focus on in vivo evidence
Carter, L. G., D'Orazio, J. A., & Pearson, K. J. (2014) · Endocrine-Related Cancer · doi:10.1530/erc-13-0171 · Cited by 522
Epigenetic diet: impact on the epigenome and cancer
Hardy, T. M., & Tollefsbol, T. O. (2011) · Epigenomics · doi:10.2217/epi.11.71 · Cited by 401
Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence
Kotecha, R., Takami, A., & Espinoza, J. L. (2016) · Oncotarget · doi:10.18632/oncotarget.9593 · Cited by 396
Vinegar Functions on Health: Constituents, Sources, and Formation Mechanisms
Chen, H., Chen, T., Giudici, P., & Chen, F. (2016) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12228 · Cited by 232
Metadata
- Authors
- Shukla, Y., & Singh, R.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2011-01
- Volume
- 1215
- Issue
- 1
- Pages
- 1-8
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1539913349
- Cited by
- 271
- References
- 45
- FWCI
- 10.58
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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