The DOI matches its Crossref record; 141 of the 141 references it cites were found in a registry or an index.
Resveratrol and cancer: focus on in vivo evidence
Open accessAbstract
Resveratrol is a naturally occurring polyphenol that provides a number of anti-aging health benefits including improved metabolism, cardioprotection, and cancer prevention. Much of the work on resveratrol and cancer comes from in vitro studies looking at resveratrol actions on cancer cells and pathways. There are, however, comparatively fewer studies that have investigated resveratrol treatment and cancer outcomes in vivo, perhaps limited by its poor bioavailability when taken orally. Although research in cell culture has shown promising and positive effects of resveratrol, evidence from rodents and humans is inconsistent. This review highlights the in vivo effects of resveratrol treatment on breast, colorectal, liver, pancreatic, and prostate cancers. Resveratrol supplementation in animal models of cancer has shown positive, neutral as well as negative outcomes depending on resveratrol route of administration, dose, tumor model, species, and other factors. Within a specific cancer type, there is variability between studies with respect to strain, age, and sex of animal used, timing and method of resveratrol supplementation, and dose of resveratrol used to study cancer endpoints. Together, the data suggest that many factors need to be considered before resveratrol can be used for human cancer prevention or therapy.
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2 retracted
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Cited by
Potential Adverse Effects of Resveratrol: A Literature Review
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Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases
Forni, C., Facchiano, F., Bartoli, M., Pieretti, S., Facchiano, A., D’Arcangelo, D., Norelli, S., Valle, G., Nisini, R., Beninati, S., et al. (2019) · BioMed Research International · doi:10.1155/2019/8748253 · Cited by 513
Resveratrol and Its Effects on the Vascular System
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Resveratrol, human health and winemaking perspectives
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Metadata
- Authors
- Carter, L. G., D'Orazio, J. A., & Pearson, K. J.
- Venue
- Endocrine-Related Cancer
- Publisher
- Bioscientifica
- Published
- 2014-02-05
- Volume
- 21
- Issue
- 3
- Pages
- R209-R225
- ISSN
- 1351-0088 (ISSN-L)
- 1479-6821
- OpenAlex
- W2150585579
- Cited by
- 522
- References
- 141
- FWCI
- 22.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Carter, L. G., D'Orazio, J. A., & Pearson, K. J. (2014). Resveratrol and cancer: focus on in vivo evidence. Endocrine-Related Cancer. https://doi.org/10.1530/erc-13-0171
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
