Resveratrol and health—A comprehensive review of human clinical trials

Smoliga, James M.; Baur, Joseph A.; Hausenblas, Heather A.

doi:10.1002/mnfr.201100143

Cited by 596Sirtuins and Resveratrol in MedicinePhytochemicals and Antioxidant ActivitiesAlcohol Consumption and Health Effects

Resveratrol and health—A comprehensive review of human clinical trials

Smoliga, James M., Baur, Joseph A., Hausenblas, Heather A.·2011·Molecular Nutrition & Food Research

DOI 10.1002/mnfr.201100143

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Abstract

In the past decade, the small polyphenol resveratrol has received widespread attention as either a potential therapy or as a preventive agent for numerous diseases. Studies using purified enzymes, cultured cells, and laboratory animals have suggested that resveratrol has anti‐aging, anti‐carcinogenic, anti‐inflammatory, and anti‐oxidant properties that might be relevant to chronic diseases and/or longevity in humans. Although the supporting research in laboratory models is quite substantial, only recently data has emerged to describe the effects of resveratrol supplementation on physiological responses in humans. The limited number of human clinical trials that are available has largely described various aspects of resveratrol's safety and bioavailability, reaching a consensus that it is generally well‐tolerated, but have poor bioavailability. Very few published human studies have explored the ability of resveratrol to achieve the physiological benefits that have been observed in laboratory models, although many clinical trials have recently been initiated. This review aims to examine the current state of knowledge on the effects of resveratrol on humans and to utilize this information to develop further guidelines for the implementation of human clinical trials.

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Resveratrol has antioxidant properties.
“This polyphenol has anticancer and antioxidant properties and cytoprotective and anti-inflammatory effects.”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [8]
Resveratrol has anti-inflammatory effects.
“This polyphenol also has anti-inflammatory effects. In fact, it inhibits cyclooxygenase-2 (COX-2), nuclear factor-kB (NF-kB), and other molecules involved in inflammatory processes [6,8].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [8]
Resveratrol inhibits COX-2, NF-kB, and other molecules involved in inflammatory processes.
“In fact, it inhibits cyclooxygenase-2 (COX-2), nuclear factor-kB (NF-kB), and other molecules involved in inflammatory processes [6,8].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [8]
Resveratrol has cytoprotective effects.
“Resveratrol also has cytoprotective effects and antioxidant properties, and modulates anti- and pro-apoptotic mediators, protecting cells from DNA damage.”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [8]
Resveratrol has low bioavailability.
“As reported for other polyphenols, resveratrol has a low bioavailability [8].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [8]

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Ryan, M. J., Jackson, J. R., Hao, Y., Williamson, C. L., Dabkowski, E. R., Hollander, J. M., & Alway, S. E. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq080 · Cited by 125 · see citing works
At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence
Demidenko, Z. N., & Blagosklonny, M. V. (2009) · Cell Cycle · doi:10.4161/cc.8.12.8810 · Cited by 123 · see citing works
Resveratrol suppresses body mass gain in a seasonal non-human primate model of obesity
Dal‐Pan, A., Blanc, S., & Aujard, F. (2010) · BMC Physiology · doi:10.1186/1472-6793-10-11 · Cited by 114 · see citing works
New enlightenment of French paradox: Resveratrol's potential for cancer chemoprevention and anti-cancer therapy
Liu, B.-L., Zhang, X., Zhang, W., & Zhen, H. (2007) · Cancer Biology & Therapy · doi:10.4161/cbt.6.12.5161 · Cited by 112 · see citing works
Challenges of Translating Basic Research Into Therapeutics: Resveratrol as an Example
Smoliga, J. M., Vang, O., & Baur, J. A. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr062 · Cited by 111 · see citing works
Self-citation
Mediation of endogenous antioxidant enzymes and apoptotic signaling by resveratrol following muscle disuse in the gastrocnemius muscles of young and old rats
Jackson, J. R., Ryan, M. J., Hao, Y., & Alway, S. E. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00489.2010 · Cited by 105 · see citing works
Resveratrol in cancer management: where are we and where we go from here?
Ndiaye, M. A., Kumar, R., & Ahmad, N. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05851.x · Cited by 96 · see citing works
Protective Effects of Resveratrol Against Senescence-Associated Changes in Cultured Human Fibroblasts
Giovannelli, L., Pitozzi, V., Jacomelli, M., Mulinacci, N., Laurenzana, A., Dolara, P., & Mocali, A. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq161 · Cited by 84 · see citing works
Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol‐3‐sulfate
Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., & van Breemen, R. B. (2003) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.918 · Cited by 79 · see citing works
Resveratrol Improves Insulin Resistance Hyperglycemia and Hepatosteatosis But Not Hypertriglyceridemia, Inflammation, and Life Span in a Mouse Model for Werner Syndrome
Labbé, A., Garand, C., Cogger, V. C., Paquet, É. R., Desbiens, M., Couteur, D. G. L., & Lebel, M. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq184 · Cited by 71 · see citing works
Caloric restriction or resveratrol supplementation and ageing in a non-human primate: first-year outcome of the RESTRIKAL study in Microcebus murinus
Dal‐Pan, A., Terrien, J., Pifferi, F., Botalla, R., Hardy, I., Marchal, J., Zahariev, A., Chery, I., Zizzari, P., Perret, M., et al. (2010) · AGE · doi:10.1007/s11357-010-9156-6 · Cited by 57 · see citing works
Resveratrol inhibits isoprostane production in young and aged rat brain.
Chiavaroli, A., Brunetti, L., Orlando, G., Recinella, L., Ferrante, C., Leone, S., Michele, P. D., Nisio, C. D., & Vacca, M. (2010) · PubMed · Cited by 32 · see citing works
Red wine triggers cell death and thioredoxin reductase inhibition: Effects beyond resveratrol and SIRT1
Wallenborg, K., Engskog‐Vlachos, P., Eriksson, S. E., Huijbregts, L., Arnér, E. S. J., Joseph, B., & Hermanson, O. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.02.022 · Cited by 27 · see citing works
Resveratrol and health
Vang, O., & Das, D. K. (2011) · Cited by 26 · see citing works
Resveratrol and Catechin Administration Blunts Exercise-Induced Oxidative Stress and Cytokine IL-8
Schreiber, L., McAnulty, S. R., McAnulty, L. S., Rowe, B., Hosick, P. A., Wrieden, J., Hudson, M. B., Quindry, J. C., Nieman, D. C., & Henson, D. A. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000322550.00409.e8 · Cited by 1 · see citing works
Resveratrol Supplementation, Immunological Indices And Total Antioxidant Capacity In Athletes.
Marques, L. F. J. C., Bargut, T. C. L., Pires, L., Casimiro-Lopes, G., Eleuthério, E. C. A., Donangelo, C. M., & Koury, J. C. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000355254.03336.6b · Cited by 1 · see citing works

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Phytoalexins in defense against pathogens
Ahuja, I., Kissen, R., & Bones, A. M. (2011) · Trends in Plant Science · doi:10.1016/j.tplants.2011.11.002 · Cited by 1,146 · see citing works
Interventions to slow aging in humans: are we ready?
Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown‐Borg, H. M., Caruso, C., Curiel, T. J., Cabo, R., Franceschi, C., Gems, D., et al. (2015) · Aging Cell · doi:10.1111/acel.12338 · Cited by 592 · see citing works
Small molecule SIRT1 activators for the treatment of aging and age-related diseases
Hubbard, B. P., & Sinclair, D. A. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.12.004 · Cited by 572 · see citing works
A review on the effects of current chemotherapy drugs and natural agents in treating non–small cell lung cancer
Huang, C., Ju, D., Chang, C.-F., Reddy, P. M., & Velmurugan, B. K. (2017) · Biomedicine · doi:10.1051/bmdcn/2017070423 · Cited by 483 · see citing works
Antibacterial and antifungal properties of resveratrol
Vestergaard, M., & Ingmer, H. (2019) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2019.02.015 · Cited by 482 · see citing works
High-Dose Resveratrol Supplementation in Obese Men
Poulsen, M. M., Vestergaard, P. F., Clasen, B. F., Radko, Y., Christensen, L. P., Stødkilde-Jørgensen, H., Møller, N., Jessen, N., Pedersen, S. B., & Jørgensen, J. O. L. (2013) · Diabetes · doi:10.2337/db12-0975 · Cited by 455 · see citing works
Resveratrol and Clinical Trials: The Crossroad from In Vitro Studies to Human Evidence
Tomé‐Carneiro, J., Larrosa, M., González‐Sarrías, A., Tomás-Barberán, F. A., García‐Conesa, M., & Espı́n, J. C. (2013) · Current Pharmaceutical Design · doi:10.2174/13816128113199990407 · Cited by 451 · see citing works
Resveratrol and Cardiovascular Diseases
Bonnefont‐Rousselot, D. (2016) · Nutrients · doi:10.3390/nu8050250 · Cited by 447 · see citing works
Polyphenols: Benefits to the Cardiovascular System in Health and in Aging
Khurana, S., Venkataraman, K., Hollingsworth, A., Piché, M., & Tai, T. C. (2013) · Nutrients · doi:10.3390/nu5103779 · Cited by 438 · see citing works
The role of Nrf2 in oxidative stress-induced endothelial injuries
Chen, B., Lu, Y., Chen, Y., & Cheng, J. (2015) · Journal of Endocrinology · doi:10.1530/joe-14-0662 · Cited by 400 · see citing works
Are sirtuins viable targets for improving healthspan and lifespan?
Baur, J. A., Ungvari, Z. I., Minor, R. K., Couteur, D. G. L., & de Cabo, R. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3738 · Cited by 389 · see citing works
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Nanoemulsions as delivery systems for lipophilic nutraceuticals: strategies for improving their formulation, stability, functionality and bioavailability
Choi, S. J., & McClements, D. J. (2020) · Food Science and Biotechnology · doi:10.1007/s10068-019-00731-4 · Cited by 302 · see citing works
Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician’s Expectation Be Matched by the Reality?
Houghton, C. A., Fassett, R. G., & Coombes, J. S. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/7857186 · Cited by 303 · see citing works
Metabolism and pharmacokinetics of resveratrol and pterostilbene
Wang, P., & Sang, S. (2018) · BioFactors · doi:10.1002/biof.1410 · Cited by 290 · see citing works
Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function
Kitada, M., Ogura, Y., Monno, I., & Koya, D. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00187 · Cited by 289 · see citing works
Resveratrol: from enhanced biosynthesis and bioavailability to multitargeting chronic diseases
Pannu, N., & Bhatnagar, A. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.11.075 · Cited by 289 · see citing works
Recent advances in natural products from plants for treatment of liver diseases
Zhang, A., Sun, H. J., & Wang, X. (2013) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2012.12.062 · Cited by 277 · see citing works
Lifespan and healthspan extension by resveratrol
Bhullar, K. S., & Hubbard, B. P. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.01.012 · Cited by 273 · see citing works
Cancer therapy with phytochemicals: evidence from clinical studies.
Hosseini, A., & Ghorbani, A. (2015) · Europe PMC (PubMed Central) · Cited by 273 · see citing works
Characterization of bioactive compounds and antioxidant activity of fruit beers
Nardini, M., & Garaguso, I. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.125437 · Cited by 262 · see citing works
Antihyperglycemic Effects of Short Term Resveratrol Supplementation in Type 2 Diabetic Patients
Movahed, A., Nabipour, I., Louis, X. L., Thandapilly, S. J., Yu, L., Kalantarhormozi, M., Rekabpour, S. J., & Netticadan, T. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/851267 · Cited by 258 · see citing works
Nutritional patterns associated with the maintenance of neurocognitive functions and the risk of dementia and Alzheimer's disease: a focus on human studies
Pistollato, F., Iglesias, R. C., Ruiz, R., Aparicio, S., Crespo, J., Lopez, L. D., Manna, P. P., Giampieri, F., & Battino, M. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.03.012 · Cited by 247 · see citing works
Review of recent data on the metabolism, biological effects, and toxicity of resveratrol in humans
Cottart, C., Nivet‐Antoine, V., & Beaudeux, J. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200589 · Cited by 250 · see citing works
Enhancing the Delivery of Resveratrol in Humans: If Low Bioavailability is the Problem, What is the Solution?
Smoliga, J. M., & Blanchard, O. L. (2014) · Molecules · doi:10.3390/molecules191117154 · Cited by 231 · see citing works
Self-citation
Design, Synthesis, and Evaluation of Multitarget-Directed Resveratrol Derivatives for the Treatment of Alzheimer’s Disease
Lu, C., Guo, Y., Yan, J., Luo, Z., Luo, H., Yan, M., Huang, L., & Li, X. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm400567s · Cited by 230 · see citing works
Wine and Cardiovascular Health
Haseeb, S., Alexander, B., & Baranchuk, A. M. (2017) · Circulation · doi:10.1161/circulationaha.117.030387 · Cited by 223 · see citing works
Oxidative stress and antioxidant therapy in cystic fibrosis
Galli, F., Battistoni, A., Gambari, R., Alfonso Pompella, C., Bragonzi, A., Pilolli, F., Iuliano, L., Piroddi, M., Dechecchi, M. C., & Cabrini, G. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.12.012 · Cited by 207 · see citing works
Herb–Drug Interactions: Challenges and Opportunities for Improved Predictions
Brantley, S. J., Argikar, A. A., Lin, Y. S., Nagar, S., & Paine, M. F. (2013) · Drug Metabolism and Disposition · doi:10.1124/dmd.113.055236 · Cited by 212 · see citing works
Mechanisms of Aging and the Preventive Effects of Resveratrol on Age-Related Diseases
Pyo, I. S., Yun, S., Yoon, Y. E., Choi, J. W., & Lee, S. (2020) · Molecules · doi:10.3390/molecules25204649 · Cited by 213 · see citing works
Impact of caloric and dietary restriction regimens on markers of health and longevity in humans and animals: a summary of available findings
Trepanowski, J. F., Canale, R. E., Marshall, K. E., Kabir, M. M., & Bloomer, R. J. (2011) · Nutrition Journal · doi:10.1186/1475-2891-10-107 · Cited by 204 · see citing works
Anti-Inflammatory and Antioxidant Effects of Resveratrol in Healthy Smokers A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial
Bo, S., Ciccone, G., Castiglione, A., Gambino, R., Michieli, F. D., Villois, P., Durazzo, M., Cavallo‐Perin, P., & Cassader, M. (2013) · Current Medicinal Chemistry · doi:10.2174/0929867311320100009 · Cited by 209 · see citing works
Walnuts (Juglans regia) Chemical Composition and Research in Human Health
Hayes, D., Angove, M. J., Tucci, J., & Dennis, C. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.760516 · Cited by 203 · see citing works
DCEO Biotechnology: Tools To Design, Construct, Evaluate, and Optimize the Metabolic Pathway for Biosynthesis of Chemicals
Chen, X., Gao, C., Guo, L., Hu, G., Luo, Q., Liu, J., Nielsen, J., Chen, J., & Liu, L. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00804 · Cited by 193 · see citing works
Dietary antiaging phytochemicals and mechanisms associated with prolonged survival
Si, H., & Liu, D. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.02.001 · Cited by 196 · see citing works
The impact of moderate wine consumption on health
Artero, A., Artero, A., Tarín, J. J., & Cano, A. (2014) · Maturitas · doi:10.1016/j.maturitas.2014.09.007 · Cited by 189 · see citing works
Antidepressant active ingredients from herbs and nutraceuticals used in TCM: pharmacological mechanisms and prospects for drug discovery
Wang, Y.-S., Shen, C., & Jiang, J. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104520 · Cited by 183 · see citing works
The mouse as a model organism in aging research: Usefulness, pitfalls and possibilities
Vanhooren, V., & Libert, C. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.03.010 · Cited by 180 · see citing works
Therapeutic Versatility of Resveratrol Derivatives
Nawaz, W., Zhou, Z.-Q., Deng, S., Ma, X., Ma, X., Li, C., & Shu, X. H. (2017) · Nutrients · doi:10.3390/nu9111188 · Cited by 175 · see citing works
Resveratrol treatment as an adjunct to pharmacological management in type 2 diabetes mellitus—systematic review and meta‐analysis
Hausenblas, H. A., Schoulda, J. A., & Smoliga, J. M. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400173 · Cited by 175 · see citing works
Self-citation
The journey of resveratrol from yeast to human
Timmers, S., Auwerx, J. H., & Schrauwen, P. (2012) · Aging · doi:10.18632/aging.100445 · Cited by 174 · see citing works
Plant Hormesis Management with Biostimulants of Biotic Origin in Agriculture
Vargas-Hernández, M., Macias-Bobadilla, I., Guevara-González, R. G., Romero‐Gómez, S. D. J., Rico-García, E., Ocampo-Velazquez, R. V., Alvarez-Arquieta, L. D. L., & Torres‐Pacheco, I. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01762 · Cited by 171 · see citing works
The effects of resveratrol on markers of oxidative stress in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial
Seyyedebrahimi, S., Khodabandehloo, H., Nasli‐Esfahani, E., & Meshkani, R. (2018) · Acta Diabetologica · doi:10.1007/s00592-017-1098-3 · Cited by 167 · see citing works
Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases
Ramis, M. R., Esteban, S., Miralles, A., Tan, D., & Reiter, R. J. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.03.008 · Cited by 164 · see citing works
Resveratrol: Twenty Years of Growth, Development and Controversy
Pezzuto, J. M. (2018) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2018.176 · Cited by 164 · see citing works
Unravelling the mechanisms regulating muscle mitochondrial biogenesis
Hood, D. A., Tryon, L. D., Carter, H. N., Kim, Y., & Chen, C. C. W. (2016) · Biochemical Journal · doi:10.1042/bcj20160009 · Cited by 159 · see citing works
Resveratrol alleviates non-alcoholic fatty liver disease through epigenetic modification of the Nrf2 signaling pathway
Hosseini, H., Teimouri, M., Shabani, M., Koushki, M., Khorzoughi, R. B., Namvarjah, F., Izadi, P., & Meshkani, R. (2019) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2019.105667 · Cited by 157 · see citing works
Aging and dry eye disease
Ding, J., & Sullivan, D. A. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.03.020 · Cited by 151 · see citing works
Phenotyping the effect of diet on non-alcoholic fatty liver disease
de Wit, N. J. W., Afman, L. A., Mensink, M., & Müller, M. M. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.07.003 · Cited by 149 · see citing works
Resveratrol ameliorates podocyte damage in diabetic mice via SIRT1/PGC‐1α mediated attenuation of mitochondrial oxidative stress
Zhang, T., Chi, Y., Kang, Y., Lu, H., Niu, H., Liu, W., & Li, Y. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27306 · Cited by 148 · see citing works
Drug interaction potential of resveratrol
Detampel, P., Beck, M., Krähenbühl, S., & Huwyler, J. (2012) · Drug Metabolism Reviews · doi:10.3109/03602532.2012.700715 · Cited by 145 · see citing works
Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging
Sarubbo, F., Esteban, S., Miralles, A., & Moranta, D. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170703113212 · Cited by 144 · see citing works
Resveratrol ameliorates diabetes‐related metabolic changes via activation of AMP‐activated protein kinase and its downstream targets in db/db mice
Do, G., Jung, U. J., Park, H., Kwon, E., Jeon, S.-M., McGregor, R. A., & Choi, M. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200067 · Cited by 141 · see citing works
Absorption and Metabolism of Piceatannol in Rats
Setoguchi, Y., Oritani, Y., Ito, R., Inagaki, H., Maruki‐Uchida, H., Ichiyanagi, T., & Ito, T. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf404694y · Cited by 139 · see citing works
Resveratrol for primary prevention of atherosclerosis: Clinical trial evidence for improved gene expression in vascular endothelium
Agarwal, B., Campen, M. J., Channell, M. M., Wherry, S. J., Varamini, B., Davis, J. G., Baur, J. A., & Smoliga, J. M. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.09.027 · Cited by 137 · see citing works
Self-citation
MicroRNA, Nutrition, and Cancer Prevention
Ross, S. A., & Davis, C. D. (2011) · Advances in Nutrition · doi:10.3945/an.111.001206 · Cited by 135 · see citing works
Pharmacokinetics and tolerability of SRT 2104, a first‐in‐class small molecule activator of SIRT 1, after single and repeated oral administration in man
Hoffmann, E. C., Wald, J., Lavu, S., Roberts, J., Beaumont, C., Haddad, J., Elliott, P. J., Westphal, C. H., & Jacobson, E. W. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04340.x · Cited by 133 · see citing works
Pharmacokinetics of pterostilbene in S prague‐ D awley rats: The impacts of aqueous solubility, fasting, dose escalation, and dosing route on bioavailability
Yeo, S. C. M., Ho, P. C., & Lin, H. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200651 · Cited by 131 · see citing works
Mediterranean Way of Drinking and Longevity
Giacosa, A., Barale, R., Bavaresco, L., Faliva, M. A., Gerbi, V., Vecchia, C. L., Negri, E., Opizzi, A., Perna, S., Pezzotti, M., et al. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.747484 · Cited by 129 · see citing works
Resveratrol-loaded liposomes for topical treatment of the vaginal inflammation and infections
Jøraholmen, M. W., Škalko‐Basnet, N., Acharya, G., & Basnet, P. (2015) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2015.09.007 · Cited by 129 · see citing works
The polyphenols resveratrol and epigallocatechin-3-gallate restore the severe impairment of mitochondria in hippocampal progenitor cells from a Down syndrome mouse model
Valenti, D., Lidia de, B. A. R. I., Rasmo, D. D., Signorile, A., Henrion‐Caude, A., Contestabile, A., & Vacca, R. A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.03.003 · Cited by 128 · see citing works
Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice
Bruckbauer, A., Zemel, M. B., Thorpe, T., Akula, M. R., Stuckey, A. C., Osborne, D., Martin, E. B., Kennel, S. J., & Wall, J. S. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-77 · Cited by 128 · see citing works
Curcumin and Resveratrol in the Management of Cognitive Disorders: What is the Clinical Evidence?
Mazzanti, G., & Giacomo, S. D. (2016) · Molecules · doi:10.3390/molecules21091243 · Cited by 130 · see citing works
Plant-Derivatives Small Molecules with Antibacterial Activity
Alibí, S., Crespo, D., & Navas, J. (2021) · Antibiotics · doi:10.3390/antibiotics10030231 · Cited by 134 · see citing works
Protective effect of resveratrol against doxorubicin-induced cardiac toxicity and fibrosis in male experimental rats
Arafa, M. H., Mohammad, N. S., Atteia, H. H., & Abdel‐Aziz, H. R. (2014) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-014-0339-y · Cited by 125 · see citing works
Lactobacillus acidophilus Metabolizes Dietary Plant Glucosides and Externalizes Their Bioactive Phytochemicals
Theilmann, M. C., Goh, Y. J., Nielsen, K. F., Klaenhammer, T. R., Barrangou, R., & Hachem, M. A. (2017) · mBio · doi:10.1128/mbio.01421-17 · Cited by 125 · see citing works
Comparative Analyses of Stilbenoids in Canes of Major Vitis vinifera L. Cultivars
Lambert, C., Richard, T., Renouf, E., Bisson, J. I., Waffo‐Téguo, P., Bordenave, L., Ollat, N., Mérillon, J., & Cluzet, S. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf403716y · Cited by 122 · see citing works
Polyphenols and the Human Brain: Plant “Secondary Metabolite” Ecologic Roles and Endogenous Signaling Functions Drive Benefits
Kennedy, D. O. (2014) · Advances in Nutrition · doi:10.3945/an.114.006320 · Cited by 125 · see citing works
Cardiac changes associated with vascular aging
Singam, N. S. V., Fine, C., & Fleg, J. L. (2019) · Clinical Cardiology · doi:10.1002/clc.23313 · Cited by 127 · see citing works
Cell senescence in liver diseases: pathological mechanism and theranostic opportunity
Sanfeliu-Redondo, D., Gibert-Ramos, A., & Gracia-Sancho, J. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00913-4 · Cited by 117 · see citing works
Piceatannol, a resveratrol derivative, promotes glucose uptake through glucose transporter 4 translocation to plasma membrane in L6 myocytes and suppresses blood glucose levels in type 2 diabetic model db/db mice
Minakawa, M., Miura, Y., & Yagasaki, K. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.05.017 · Cited by 114 · see citing works
X‐yne click polymerization
Fu, X., Qin, A., & Tang, B. Z. (2023) · Aggregate · doi:10.1002/agt2.350 · Cited by 112 · see citing works
Skin resistance to oxidative stress induced by resveratrol: From Nrf2 activation to GSH biosynthesis
Sœur, J., Eilstein, J., Léreaux, G., Jones, C., & Marrot, L. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.10.510 · Cited by 110 · see citing works
Potential of resveratrol in the treatment of heart failure
Raj, P., Louis, X. L., Thandapilly, S. J., Movahed, A., Zieroth, S. R., & Netticadan, T. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.12.011 · Cited by 109 · see citing works
Resveratrol limits diabetes-associated cognitive decline in rats by preventing oxidative stress and inflammation and modulating hippocampal structural synaptic plasticity
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Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities
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Self-citation
Resveratrol supplementation: Where are we now and where should we go?
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Authors: Smoliga, J. M., Baur, J. A., & Hausenblas, H. A.
Affiliations: Marywood University (US)
University of Pennsylvania (US)
University of Florida (US)
Corresponding author: Smoliga, James M.
ORCID: Smoliga, James M.
Baur, Joseph A.
Hausenblas, Heather A.
Venue: Molecular Nutrition & Food Research
Publisher: Wiley
Published: 2011-06-20
Volume: 55
Issue: 8
Pages: 1129-1141
ISSN: 1613-4125 (ISSN-L)
1613-4133
DOI: 10.1002/mnfr.201100143
OpenAlex: W2031213396
Cited by: 594
References: 87
Citations by year: 2026: 21 · 2025: 37 · 2024: 22 · 2023: 23 · 2022: 29 · 2021: 30 · 2020: 36 · 2019: 41 · 2018: 51 · 2017: 40 · 2016: 37 · 2015: 43 · 2014: 60 · 2013: 69 · 2012: 47
FWCI: 4.86
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Molecular Nutrition & Food Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords: resveratrol, polyphenols, bioavailability, safety, anti-aging, anti-carcinogenic effects, anti-inflammatory activity, antioxidant activity, chronic disease prevention, longevity, dietary supplementation
MeSH terms: Resveratrol, Animals, Biological Availability, Cardiovascular Diseases, Clinical Trials as Topic, Diabetes Mellitus, Humans, Liver, Obesity, Stilbenes, Wine, Oxidative Stress, Dietary Supplements

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Resveratrol and health—A comprehensive review of human clinical trials

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