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Scavenger receptor class B type I: a multifunctional receptor
Open accessAbstract
The scavenger receptor class B type I (SR‐B1) plays an important role in meditating the uptake of HDL‐derived cholesterol and cholesteryl ester in the liver and steroidogenic tissues. In addition to being ubiquitous, SR‐B1 is a high‐density lipoprotein (HDL) receptor in many tissues, though the mechanism by which SR‐B1 does this is unclear. Other than its role as an HDL receptor, SR‐B1 is also involved in pathogen recognition; its expression can be modulated by lipopolysaccharide and oxidative stress; and it plays a significant role in the uptake of lipid soluble vitamins, such as vitamin E and carotenoids. In this short review, we have summarized the biological aspects to which SR‐B1 has been thus far associated.
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“Additionally, SCARB1 can also serve as a transporter for vitamins, including tocopherols, and carotenoids such as β-carotene and xanthophylls [10,11].”
From Vitamin A Transporters in Visual Function: A Mini Review on Membrane Receptors for Dietary Vitamin A Uptake, Storage, and Transport to the Eye (2021) · cites this paper as [10]
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Metadata
- Authors
- Valacchi, G., Sticozzi, C., Lim, Y., & Pecorelli, A.
- Affiliations
- University of Ferrara (IT)
- University of Trento (IT)
- Kyung Hee University (KR)
- University of Siena (IT)
- Corresponding author
- Valacchi, Giuseppe
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2011-07
- Volume
- 1229
- Issue
- 1
- Pages
- E1-7
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1671549322
- Semantic Scholar
- 8d8aa42c23deabac7c734ebce862fbf1ccf9108b
- Cited by
- 108
- References
- 82
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 8 · 2020: 8 · 2019: 9 · 2018: 6 · 2017: 15 · 2016: 6 · 2015: 13 · 2014: 15 · 2013: 6 · 2012: 6
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- scavenger receptor class B type I, HDL cholesterol uptake, cholesterol esters, liver, steroidogenic tissues, HDL receptor, pathogen recognition, lipopolysaccharide, oxidative stress, carotenoid uptake, fat-soluble vitamins
- MeSH terms
- Adrenal Cortex, Animals, Biological Transport, Carotenoids, Cholesterol Esters, Humans, Lipopolysaccharides, Cholesterol, HDL, Liver, Lung, Membrane Proteins, Tissue Distribution, Vitamin E, Mice, Knockout, Oxidative Stress, CD36 Antigens, Mice, Rats, Hep G2 Cells
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