The Psychiatric GWAS Consortium: Big Science Comes to Psychiatry
Open accessAbstract
The Psychiatric GWAS Consortium was founded with the aim of conducting statistically rigorous and comprehensive GWAS meta-analyses for five major psychiatric disorders: ADHD, autism, bipolar disorder, major depressive disorder, and schizophrenia. In the era of GWAS and high-throughput genomics, a major trend has been the emergence of collaborative, consortia approaches. Taking advantage of the scale that collaborative consortia approaches can bring to a problem, the PGC has been a major driver in psychiatric genetics and provides a model for how similar approaches may be applied to other disease communities.
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T2DM and breast cancer loci identified in European samples tend to replicate in samples of East Asian ancestry.
“For example, T2DM and breast cancer loci identified in European samples tend to replicate in samples of East Asian ancestry. 150,151”
From Genetic architectures of psychiatric disorders: the emerging picture and its implications (2012) · cites this paper as [150]
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- Authors
- Sullivan, P. F.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Sullivan, Patrick F.
- ORCID
- Sullivan, Patrick F.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 68
- Issue
- 2
- Pages
- 182-186
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2991765
- OpenAlex
- W2079849867
- Cited by
- 285
- References
- 25
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 11 · 2023: 11 · 2022: 18 · 2021: 15 · 2020: 30 · 2019: 22 · 2018: 17 · 2017: 15 · 2016: 18 · 2015: 32 · 2014: 22 · 2013: 18 · 2012: 20
- FWCI
- 9.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- START, Global Change System for Analysis, Research, and Training
- National Institute of Mental Health (R01MH077139, U01MH085520, MH085520)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- psychiatric genetics, genome-wide association study, meta-analysis, big science, attention deficit hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, schizophrenia
- MeSH terms
- Mental Disorders, Humans, Neurobiology, Psychiatry, Meta-Analysis as Topic, History, 20th Century, History, 21st Century, Genome-Wide Association Study
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