Sarcopenia and smoking: A possible cellular model of cigarette smoke effects on muscle protein breakdown
Abstract
Sarcopenia, the age‐related loss of muscle mass and strength, is a multifactorial impaired state of health. Lifestyle habits such as physical activity and nutrition have a major impact on sarcopenia progression. Several epidemiological studies have also shown an association between cigarette smoking and increased levels of sarcopenia in elderly long‐time smokers. Clinical, in vivo, and in vitro studies have tried to investigate the mechanism behind exposure to cigarette smoke (CS) and the subsequent effects on skeletal muscles. The aim of this review is to present a cellular model of CS‐induced skeletal muscle protein breakdown based on recent studies dealing with this issue and to propose new potential research directions that may explain the effects of exposure to CS on skeletal muscle integrity.
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Cigarette smoking is associated with sarcopenia, and compounds present in cigarette smoke degrade proteins in muscle tissue.
“An association between cigarette smoking and sarcopenia has also been reported as an indirect effect. Compounds present in cigarette smoke have been shown to degrade proteins in muscle tissue [28,29].”
From Skeletal System Biology and Smoke Damage: From Basic Science to Medical Clinic (2021) · cites this paper as [29]
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Skeletal System Biology and Smoke Damage: From Basic Science to Medical Clinic
Tarantino, U., Cariati, I., Greggi, C., Gasbarra, E., Belluati, A., Ciolli, L., Maccauro, G., Momoli, A., Ripanti, S., Falez, F., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126629 · Cited by 52 · see citing works
Obesity, Sarcopenia, and Smoking: Landscape in the Mist
Oh, S.-W. (2019) · Korean Journal of Family Medicine · doi:10.4082/kjfm.40.2e · Cited by 4 · see citing works
- Authors
- Rom, O., Kaisari, S., Aizenbud, D., & Reznick, A. Z.
- Affiliations
- Technion – Israel Institute of Technology (IL)
- Corresponding author
- Reznick, Abraham Z.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2012-07
- Volume
- 1259
- Issue
- 1
- Pages
- 47-53
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1511289678
- Cited by
- 112
- References
- 41
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 9 · 2023: 10 · 2022: 12 · 2021: 14 · 2020: 13 · 2019: 4 · 2018: 6 · 2017: 2 · 2016: 1 · 2015: 6 · 2014: 5 · 2013: 8 · 2012: 3
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- sarcopenia, cigarette smoking, cigarette smoke, muscle protein degradation, cell model, aging, muscle mass loss, muscle integrity
- MeSH terms
- Aged, Aging, Animals, Humans, Models, Biological, Muscle Proteins, Smoking, Tobacco Smoke Pollution, Muscle, Skeletal, Sarcopenia, Proteolysis
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