Cited by 112Nutrition and Health in AgingMuscle Physiology and DisordersMuscle metabolism and nutrition

Sarcopenia and smoking: A possible cellular model of cigarette smoke effects on muscle protein breakdown

Rom, Oren, Kaisari, Sharon, Aizenbud, Dror, Reznick, Abraham Z.·2012·Annals of the New York Academy of Sciences

Abstract

Sarcopenia, the age‐related loss of muscle mass and strength, is a multifactorial impaired state of health. Lifestyle habits such as physical activity and nutrition have a major impact on sarcopenia progression. Several epidemiological studies have also shown an association between cigarette smoking and increased levels of sarcopenia in elderly long‐time smokers. Clinical, in vivo, and in vitro studies have tried to investigate the mechanism behind exposure to cigarette smoke (CS) and the subsequent effects on skeletal muscles. The aim of this review is to present a cellular model of CS‐induced skeletal muscle protein breakdown based on recent studies dealing with this issue and to propose new potential research directions that may explain the effects of exposure to CS on skeletal muscle integrity.

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Crossref · 10.1111/j.1749-6632.2012.06532.x

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41 of 41 references verified0 citation errors · 0 not checkable

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  • Cigarette smoking is associated with sarcopenia, and compounds present in cigarette smoke degrade proteins in muscle tissue.

    “An association between cigarette smoking and sarcopenia has also been reported as an indirect effect. Compounds present in cigarette smoke have been shown to degrade proteins in muscle tissue [28,29].”

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Authors
Rom, O., Kaisari, S., Aizenbud, D., & Reznick, A. Z.
Affiliations
Technion – Israel Institute of Technology (IL)
Corresponding author
Reznick, Abraham Z.
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2012-07
Volume
1259
Issue
1
Pages
47-53
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
OpenAlex
W1511289678
Cited by
112
References
41
Citations by year
2026: 9 · 2025: 10 · 2024: 9 · 2023: 10 · 2022: 12 · 2021: 14 · 2020: 13 · 2019: 4 · 2018: 6 · 2017: 2 · 2016: 1 · 2015: 6 · 2014: 5 · 2013: 8 · 2012: 3
FWCI
0.77
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
sarcopenia, cigarette smoking, cigarette smoke, muscle protein degradation, cell model, aging, muscle mass loss, muscle integrity
MeSH terms
Aged, Aging, Animals, Humans, Models, Biological, Muscle Proteins, Smoking, Tobacco Smoke Pollution, Muscle, Skeletal, Sarcopenia, Proteolysis

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