Cited by 295Nutrition and Health in AgingMuscle Physiology and DisordersMuscle metabolism and nutrition

Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy

Open access
Buford, Thomas W., Anton, Stephen D., Judge, Andrew R., Marzetti, Emanuele, Wohlgemuth, Stephanie E., Carter, Christy S., Leeuwenburgh, Christiaan, Pahor, Marco +1 more·2010·Ageing Research Reviews

Abstract

Sarcopenia, the age-related loss of skeletal muscle mass, is a significant public health concern that continues to grow in relevance as the population ages. Certain conditions have the strong potential to coincide with sarcopenia to accelerate the progression of muscle atrophy in older adults. Among these conditions are co-morbid diseases common to older individuals such as cancer, kidney disease, diabetes, and peripheral artery disease. Furthermore, behaviors such as poor nutrition and physical inactivity are well-known to contribute to sarcopenia development. However, we argue that these behaviors are not inherent to the development of sarcopenia but rather accelerate its progression. In the present review, we discuss how these factors affect systemic and cellular mechanisms that contribute to skeletal muscle atrophy. In addition, we describe gaps in the literature concerning the role of these factors in accelerating sarcopenia progression. Elucidating biochemical pathways related to accelerated muscle atrophy may allow for improved discovery of therapeutic treatments related to sarcopenia.

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Crossref · 10.1016/j.arr.2010.04.004

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  • HIV is associated with increased circulating concentrations of pro-inflammatory cytokines that can alter protein balance similarly to cancer.

    “HIV is also associated with increased circulating concentrations of pro-inflammatory cytokines that can alter protein balance similarly to cancer.109”
  • Chronic or intermittent hypoxaemia could affect mitochondrial function in a way similar to age-related muscle loss, leading to oxidative stress, reduced energy availability, and decreased protein synthesis.

    “Chronic or intermittent hypoxaemia could also affect mitochondrial function in a similar way to age-related muscle loss, leading to oxidative stress, reduced energy availability, and decreased protein synthesis.”
  • Repeated episodes of ischaemia-reperfusion might be a common pathway for muscle loss in peripheral arterial disease, congestive heart failure, and COPD by causing damage that exhausts the repairing capacity of satellite cells.

    “Repeated episodes of ischaemia-reperfusion might be a common pathway associated with muscle loss in many medical conditions—including peripheral arterial disease, congestive heart failure, and COPD—that cause damage necessitating frequent regeneration, and exhaust the repairing capacity of resident satellite cells.”

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1 retracted

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Authors
Buford, T. W., Anton, S. D., Judge, A. R., Marzetti, E., Wohlgemuth, S. E., Carter, C. S., Leeuwenburgh, C., Pahor, M., & Manini, T. M.
Affiliations
University of Florida (US)
Corresponding author
  • Buford, Thomas W.
  • Manini, Todd M.
Venue
Ageing Research Reviews
Publisher
Elsevier BV
Published
2010-10
Volume
9
Issue
4
Pages
369-383
ISSN
1568-1637 (ISSN-L)
OpenAlex
W1967880601
Cited by
295
References
272
Citations by year
2026: 4 · 2025: 10 · 2024: 17 · 2023: 22 · 2022: 16 · 2021: 24 · 2020: 19 · 2019: 12 · 2018: 20 · 2017: 24 · 2016: 21 · 2015: 25 · 2014: 17 · 2013: 17 · 2012: 29
FWCI
2.04
Type
journal article
Language
en
Open access
Locations
  • Ageing Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Aging (P30AG028740)
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
sarcopenia, age-related muscle loss, skeletal muscle, comorbidities, cancer, kidney disease, diabetes mellitus, peripheral arterial disease, nutrition, physical inactivity, therapeutic target
MeSH terms
Acceleration, Aged, Aged, 80 and over, Aging, Diabetes Mellitus, Feeding Behavior, Humans, Kidney Diseases, Health Knowledge, Attitudes, Practice, Models, Biological, Motor Activity, Neoplasms, Nutritional Requirements, Comorbidity, Apoptosis, Muscle, Skeletal, Sarcopenia, Peripheral Arterial Disease

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