TNF‐α‐mediated reduction in PGC‐1α may impair skeletal muscle function after cigarette smoke exposure
Open accessAbstract
Skeletal muscle dysfunction contributes to exercise limitation in COPD. In this study cigarette smoke exposure was hypothesized to increase expression of the inflammatory cytokine, TNF-alpha, thereby suppressing PGC-1alpha, and hence affecting down stream molecules that regulate oxygen transport and muscle function. Furthermore, we hypothesized that highly vascularized oxidative skeletal muscle would be more susceptible to cigarette smoke than less well-vascularized glycolytic muscle. To test these hypotheses, mice were exposed to cigarette smoke daily for 8 or 16 weeks, resulting in 157% (8 weeks) and 174% (16 weeks) increases in serum TNF-alpha. Separately, TNF-alpha administered to C2C12 myoblasts was found to dose-dependently reduce PGC-1alpha mRNA. In the smoke-exposed mice, PGC-1alpha mRNA was decreased, by 48% in soleus and 23% in EDL. The vascular PGC-1alpha target molecule, VEGF, was also down-regulated, but only in the soleus, which exhibited capillary regression and an oxidative to glycolytic fiber type transition. The apoptosis PGC-1alpha target genes, atrogin-1 and MuRF1, were up-regulated, and to a greater extent in the soleus than EDL. Citrate synthase (soleus-19%, EDL-17%) and beta-hydroxyacyl CoA dehydrogenase (beta-HAD) (soleus-22%, EDL-19%) decreased similarly in both muscle types. There was loss of body and gastrocnemius complex mass, with rapid soleus but not EDL fatigue and diminished exercise endurance. These data suggest that in response to smoke exposure, TNF-alpha-mediated down-regulation of PGC-1alpha may be a key step leading to vascular and myocyte dysfunction, effects that are more evident in oxidative than glycolytic skeletal muscles.
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A mouse model exposed to cigarette smoke exhibited increased circulating TNF-α levels, which were correlated to detrimental outcomes such as muscle mass, decreased capillarization, and increased catabolism.
“a mouse model exposed to CS and exhibiting increased circulating TNF-α levels, which were correlated to detrimental outcomes such as muscle mass, decreased capillarization, and increased catabolism [41].”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [41]
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Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983 · see citing works
(1974) · Elsevier eBooks · doi:10.1016/b978-0-12-091304-6.x5001-0 · Cited by 6,786 · see citing works
Rabe, K. F., Hurd, S., Anzueto, A., Barnes, P. J., Buist, S. A., Calverley, P., Fukuchi, Y., Jenkins, C., Rodriguez-Roisin, R., van Weel, C., et al. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200703-456so · Cited by 4,925 · see citing works
Rabe, K. F. (2007) · American Journal of Respiratory and Critical Care Medicine · Cited by 2,567 · see citing works
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546 · cited 2× · see citing works
“Furthermore, because PGC-1a plays a role in mitochondrial biogenesis and capillary regulation (Lin et al., 2002; Handschin et al., 2007; Arany et al., 2008), the soleus, composed mostly of oxidative fibers with a high mitochondrial content and vessel density, was compared to the extensor digitorum…”
BackgroundSrere, P. A. (1969) · Methods in Enzymology · doi:10.1016/0076-6879(69)13005-0 · Cited by 2,005 · cited 1× · see citing works
“Citrate synthase (CS) and b-hydroxyacyl CoA dehydrogenase (b-HAD) activity assays CS activity in the homogenates was measured (indirectly with the oxaloacetate method) with a Citrate Synthase Assay Kit (Sigma, St. Louis, MO), following the manufacture’s protocol (Srere, 1969).”
MethodRequirement for Macrophage Elastase for Cigarette Smoke-Induced Emphysema in Mice
Hautamaki, R. D., Kobayashi, D. K., Senior, R. M., & Shapiro, S. D. (1997) · Science · doi:10.1126/science.277.5334.2002 · Cited by 1,470 · cited 1× · see citing works
“This covers a period prior to destruction of the lung (emphysema) (Wright and Churg, 1990; Hautamaki et al., 1997; Gosker et al., 2008), and was chosen to minimize the possible influences of pulmonary dysfunction itself on exercise performance.”
BackgroundTisdale, M. J. (2009) · Physiological Reviews · doi:10.1152/physrev.00016.2008 · Cited by 1,192 · cited 2× · see citing works
“The ubiquitin-proteasome pathway non-selectively degrades myosin in all types of skeletal muscle (Attaix et al., 2008; Tisdale, 2009).”
BackgroundWeight Loss Is a Reversible Factor in the Prognosis of Chronic Obstructive Pulmonary Disease
Schols, A. M. W. J., Slangen, J. J. M., Volovics, L., & Wouters, E. F. �. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.6.9705017 · Cited by 1,084 · see citing works
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α
Arany, Z., Foo, S.-Y., Ma, Y., Ruas, J. L., Bommi-Reddy, A., Girnun, G., Cooper, M., Laznik, D., Chinsomboon, J., Rangwala, S. M., et al. (2008) · Nature · doi:10.1038/nature06613 · Cited by 1,054 · cited 3× · see citing works
“First, VEGF is a target gene of the PGC-1a, and studies in PGC-1a knockout mice have suggested that PGC-1a is necessary for exercise-induced VEGF expression as well as capillary adaptation to exercise training (Arany et al., 2008; Leick et al., 2009).”
BackgroundSandri, M., Lin, J., Handschin, C., Yang, W., Arany, Z. P., Lecker, S. H., Goldberg, A. L., & Spiegelman, B. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607795103 · Cited by 974 · cited 1× · see citing works
“…of PGC-1a may be mediated by a combination of both a loss of VEGF-dependent capillaries supplying oxygen to the muscle and altered regulation of genes important for mitochondrial biogenesis, type IIa fiber preservation and prevention of muscle atrophy (Sandri et al., 2006; Handschin et al., 2007).”
BackgroundArany, Z., He, H., Lin, J., Hoyer, K., Handschin, C., Toka, O., Ahmad, F., Matsui, T., Chin, S., Wu, P.-H., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.03.002 · Cited by 694 · cited 1× · see citing works
“PGC-1a also has the potential to regulate several target genes that regulated myocyte function including those involved in mitochondrial biogenesis, skeletal muscle fiber type switching, and atrophy (Lin et al., 2002; Arany et al., 2005; Handschin et al., 2007; Adhihetty et al., 2009).”
BackgroundHandschin, C., Chin, S., Li, P., Liu, F., Maratos-Flier, E., LeBrasseur, N. K., Yan, Z., & Spiegelman, B. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704817200 · Cited by 611 · cited 5× · see citing works
“Furthermore, because PGC-1a plays a role in mitochondrial biogenesis and capillary regulation (Lin et al., 2002; Handschin et al., 2007; Arany et al., 2008), the soleus, composed mostly of oxidative fibers with a high mitochondrial content and vessel density, was compared to the extensor digitorum…”
BackgroundInfluentialSchols, A. M. W. J., Buurman, W. A., den Brekel, A. J. S.-V., Dentener, M. A., & Wouters, E. F. �. (1996) · Thorax · doi:10.1136/thx.51.8.819 · Cited by 520 · cited 3× · see citing works
“In addition to the damaging effects cigarette smoke exerts on the lung, several associated extrapulmonary pathologies have been found to occur in peripheral organs (Schols et al., 1996; Jobin et al., 1998; Maltais et al., 1998; Rabinovich et al., 2001).”
BackgroundTumor Necrosis Factor-Alpha Levels and Weight Loss in Chronic Obstructive Pulmonary Disease
Di Francia, M., Barbier, D., Mège, J. L., & OREHEK, J. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.150.5.7952575 · Cited by 480 · see citing works
WHITTOM, F., JOBIN, J., SIMARD, P.-M., LEBLANC, P., SIMARD, C., BERNARD, S., BELLEAU, R., & MALTAIS, F. (1998) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199810000-00001 · Cited by 447 · cited 3× · see citing works
“…and animal models exposed to cigarette smoke present a decrease in skeletal muscle fiber size, reduced oxidative enzyme activity, capillary regression and a shift in muscle fiber composition from oxidative to glycolytic fiber types (Jobin et al., 1998; Whittom et al., 1998; Gosker et al., 2008).”
BackgroundTakabatake, N., Nakamura, H., Abe, S., Inoue, S., Hino, T., SAITO, H., YUKI, H., Kato, S., & Tomoike, H. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.4.9903022 · Cited by 325 · cited 1× · see citing works
“In particular, the inflammatory cytokine, TNF-a, has been associated with cachexia, or muscle wasting, that occurs in subpopulations of COPD patients (Di Francia et al., 1994; Schols et al., 1996; Takabatake et al., 2000).”
BackgroundAngiogenic growth factor mRNA responses in muscle to a single bout of exercise
Breen, E. C., Johnson, E. C., Wagner, H., Tseng, H. M., Sung, L. A., & Wagner, P. D. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.1.355 · Cited by 302 · cited 1× · see citing works
“L I S S , I N C . functions as a co-factor with ERR to regulate the exercise-induced angiogenic factor, VEGF (Breen et al., 1996; Arany et al., 2008), and PGC-1a knockout mice have recently been reported to exhibit decreases in both skeletal muscle VEGF levels and muscle capillary to fiber ratio…”
BackgroundSelf-citationNew Concepts in Chronic Obstructive Pulmonary Disease
Barnes, P. J. (2003) · Annual Review of Medicine · doi:10.1146/annurev.med.54.101601.152209 · Cited by 290 · cited 1× · see citing works
“DOI: 10.1002/jcp.21955 Cigarette smoking is a well-known risk factor for the development of COPD (Barnes, 2003).”
BackgroundInfluentialChronic Obstructive Pulmonary Disease: Capillarity and Fiber-Type Characteristics of Skeletal Muscle
Jobin, J., Maltais, F., Doyon, J.-F., LeBlanc, P., Simard, P.-M., Simard, A.-A., & Simard, C. (1998) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-199811000-00005 · Cited by 224 · cited 4× · see citing works
“In addition to the damaging effects cigarette smoke exerts on the lung, several associated extrapulmonary pathologies have been found to occur in peripheral organs (Schols et al., 1996; Jobin et al., 1998; Maltais et al., 1998; Rabinovich et al., 2001).”
BackgroundInfluentialMolecular regulation of individual skeletal muscle fibre types
Spangenburg, E. E., & Booth, F. W. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2003.01158.x · Cited by 208 · cited 1× · see citing works
“…of oxidative fibers with a high mitochondrial content and vessel density, was compared to the extensor digitorum longus (EDL), which is essentially glycolytic (lower mitochondrial and capillary number) (Spangenburg and Booth, 2003), with the expectation that the soleus would be more affected.”
BackgroundCapillary regression in vascular endothelial growth factor-deficient skeletal muscle
Tang, K., Breen, E. C., Gerber, H., Ferrara, N., & Wagner, P. D. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00023.2004 · Cited by 196 · cited 1× · see citing works
“We have previously confirmed the accuracy for capillary identification using this method by comparison to von Willebrand factor and CD31 immunohistochemistry (Tang et al., 2004).”
MethodSelf-citationCigarette Smoke Causes Physiologic and Morphologic Changes of Emphysema in the Guinea Pig
Wright, J. L., & Churg, A. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/142.6_pt_1.1422 · Cited by 192 · cited 1× · see citing works
“This covers a period prior to destruction of the lung (emphysema) (Wright and Churg, 1990; Hautamaki et al., 1997; Gosker et al., 2008), and was chosen to minimize the possible influences of pulmonary dysfunction itself on exercise performance.”
BackgroundRabinovich, R., Ardite, E., Troosters, T., Carbó, N., Alonso, J., de Suso, J. M. G., Vilaró, J., Barberà, J. A., Polo, M. F., Argilés, J. M. A., et al. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.7.2103065 · Cited by 190 · cited 1× · see citing works
“In addition to the damaging effects cigarette smoke exerts on the lung, several associated extrapulmonary pathologies have been found to occur in peripheral organs (Schols et al., 1996; Jobin et al., 1998; Maltais et al., 1998; Rabinovich et al., 2001).”
BackgroundMetabolic and hemodynamic responses of lower limb during exercise in patients with COPD
Maltais, F., Jobin, J., Sullivan, M. J., Bernard, S., WHITTOM, F., Killian, K. J., Desmeules, M., Bélanger, M., & Leblanc, P. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.84.5.1573 · Cited by 178 · cited 2× · see citing works
“In addition to the damaging effects cigarette smoke exerts on the lung, several associated extrapulmonary pathologies have been found to occur in peripheral organs (Schols et al., 1996; Jobin et al., 1998; Maltais et al., 1998; Rabinovich et al., 2001).”
BackgroundCytokine Profile in Quadriceps Muscles of Patients with Severe COPD
Barreiro, E., Schols, A. M. W. J., Polkey, M. I., Galdiz, J. B., Gosker, H. R., Swallow, E. B., Coronell, C., Gea, J., & on behalf of the ENIGMA in COPD project (2007) · Thorax · doi:10.1136/thx.2007.078030 · Cited by 175 · cited 1× · see citing works
“One consequence of cigarette smoke exposure is the presence of chronic systemic inflammation (Schols et al., 1996; Barreiro et al., 2008; Gosker et al., 2008).”
BackgroundThe role of PGC-1α on mitochondrial function and apoptotic susceptibility in muscle
Adhihetty, P. J., Uguccioni, G., Leick, L., Hidalgo, J., Pilegaard, H., & Hood, D. A. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00070.2009 · Cited by 168 · cited 2× · see citing works
“PGC-1a also has the potential to regulate several target genes that regulated myocyte function including those involved in mitochondrial biogenesis, skeletal muscle fiber type switching, and atrophy (Lin et al., 2002; Arany et al., 2005; Handschin et al., 2007; Adhihetty et al., 2009).”
BackgroundPeroxisome Proliferator-Activated Receptor Expression Is Reduced in Skeletal Muscle in COPD
Remels, A. H., Schrauwen, P., Broekhuizen, R., Willems, J., Kersten, S., Gosker, H. R., & Schols, A. M. (2007) · European Respiratory Journal · doi:10.1183/09031936.00144106 · Cited by 168 · cited 1× · see citing works
“In the experiments presented in the current study, mice exposed to just 16 weeks of cigarette smoke reproduced many of the muscle abnormalities seen in humans (Jobin et al., 1998; Maltais et al., 1998; Whittom et al., 1998; Remels et al., 2007; Gosker et al., 2009).”
BackgroundWuyam, B., Payen, J. F., Levy, P. A., Bensaidane, H., Reutenauer, H., Bas, J. L., & Benabid, A. (1992) · European Respiratory Journal · doi:10.1183/09031936.93.05020157 · Cited by 139 · cited 1× · see citing works
“However, muscle mass loss and dysfunction in COPD patients and smoke-exposed mice predominantly occurs skeletal muscles composed of oxidative fiber types (Wuyam et al., 1992; Jobin et al., 1998; Whittom et al., 1998; Gosker et al., 2008).”
BackgroundMuscle Wasting and Impaired Muscle Regeneration in a Murine Model of Chronic Pulmonary Inflammation
LANGEN, R. C. J., Schols, A. M. W. J., KELDERS, M. C. J. M., van der Velden, J. L. J., Wouters, E. F. �., & Janssen-Heininger, Y. M. W. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0103oc · Cited by 137 · cited 1× · see citing works
“In addition these TNF-a overexpressing mice have an impaired ability to regenerate skeletal muscle following hind limb suspension-induced atrophy (Langen et al., 2006).”
BackgroundPGC-1α mediates exercise-induced skeletal muscle VEGF expression in mice
Leick, L., Hellsten, Y., Fentz, J., Lyngby, S. S., Wojtaszewski, J. F. P., Hidalgo, J., & Pilegaard, H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00076.2009 · Cited by 124 · cited 4× · see citing works
“First, VEGF is a target gene of the PGC-1a, and studies in PGC-1a knockout mice have suggested that PGC-1a is necessary for exercise-induced VEGF expression as well as capillary adaptation to exercise training (Arany et al., 2008; Leick et al., 2009).”
BackgroundInfluentialMizunoya, W., Wakamatsu, J., Tatsumi, R., & Ikeuchi, Y. (2008) · Analytical Biochemistry · doi:10.1016/j.ab.2008.02.021 · Cited by 100 · cited 2× · see citing works
“Myosin heavy chain (MHC) isoform analyses MHC isoforms were analyzed by SDS–PAGE (Mizunoya et al., 2008).”
MethodInfluentialGosker, H. R., LANGEN, R. C. J., Bracke, K. R., Joos, G., Brusselle, G., Steele, C. H., Ward, K. A., Wouters, E. F. �., & Schols, A. M. W. J. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0312oc · Cited by 94 · cited 1× · see citing works
“In the experiments presented in the current study, mice exposed to just 16 weeks of cigarette smoke reproduced many of the muscle abnormalities seen in humans (Jobin et al., 1998; Maltais et al., 1998; Whittom et al., 1998; Remels et al., 2007; Gosker et al., 2009).”
BackgroundCigarette Smoke Exposure Reprograms the Hypothalamic Neuropeptide Y Axis to Promote Weight Loss
Chen, H., Hansen, M. J., Jones, J. E. C., Vlahos, R., Bozinovski, S., Anderson, G. P., & Morris, M. J. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200506-977oc · Cited by 92 · cited 1× · see citing works
“A modified cigarette smoke chamber was designed based on previously published protocols (Chen et al., 2006).”
MethodEnzymatic heterogeneity of the capillary bed of rat skeletal muscles
Mrázková, O., Grim, M., & Carlson, B. M. (1986) · American Journal of Anatomy · doi:10.1002/aja.1001770203 · Cited by 62 · cited 1× · see citing works
“…positioned vertically, mounted with OCT and quickly frozen in liquid N2-cooled isopentane and then stored at 808C. Ten micron frozen cross-sections were stained with a combined alkaline phosphatase (AP) and dipeptidylpeptidase (DPP) staining technique to reveal capillaries (Mrazkova et al., 1986).”
MethodRole of the ubiquitin-proteasome pathway in muscle atrophy in cachexia
Attaix, D., Combaret, L., Béchet, D., & Taillandier, D. (2008) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e3283196ac2 · Cited by 56 · cited 2× · see citing works
“The ubiquitin-proteasome pathway non-selectively degrades myosin in all types of skeletal muscle (Attaix et al., 2008; Tisdale, 2009).”
BackgroundKohn, T. A., & Myburgh, K. H. (2006) · The Journal of Physiological Sciences · doi:10.2170/physiolsci.rp007706 · Cited by 48 · cited 1× · see citing works
“The upper running buffer was 6 the concentration of the lower running buffer with 0.12% (v/v) b-mercaptoethanol (Kohn and Myburgh, 2006).”
MethodInfluentialPrete, Z. D., Musarò, A., & Rizzuto, E. (2008) · Annals of Biomedical Engineering · doi:10.1007/s10439-008-9496-x · Cited by 40 · see citing works
Therapeutic prospects to treat skeletal muscle wasting in COPD (chronic obstructive lung disease)
Hansen, M. J., Gualano, R. C., Bozinovski, S., Vlahos, R., & Anderson, G. P. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.06.007 · Cited by 37 · cited 1× · see citing works
“Furthermore, these changes seem to be independent of worsening lung function (Schols et al., 1998; Hansen et al., 2006).”
BackgroundGosker, H. R., Remels, A. H. V., Sliwinski, P., Polkey, M. I., Gáldiz, J. B., Wouters, E. F. �., LANGEN, R. C. J., & Schols, A. M. W. J. (2009) · doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a4200 · Cited by 1 · cited 1× · see citing works
“In the experiments presented in the current study, mice exposed to just 16 weeks of cigarette smoke reproduced many of the muscle abnormalities seen in humans (Jobin et al., 1998; Maltais et al., 1998; Whittom et al., 1998; Remels et al., 2007; Gosker et al., 2009).”
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Research works printed but not linked: 2
- Gosker HR Langen RC Bracke KR Joos GF Brusselle GG Steele C Ward KA Wouters EF Schols AM 2008 Extrapulmonary manifestations of COPD in a mouse model of chronic cigarette smoke exposure Am J Respir Cell Mol Biol 18988919
- Remels AH Schrauwen P Broekhuizen R Willems J Kersten S Gosker HR Schols AM 2007 Expression and content of PPARs is reduced in skeletal muscle of COPD patients Eur Respir J 17459894
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Self-citationPGC-1 α , Inflammation, and Oxidative Stress: An Integrative View in Metabolism
Rius‐Pérez, S., Torres-Cuevas, I., Millán, I., Ortega, Á., & Pérez, S. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1452696 · Cited by 648 · see citing works
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Rom, O., & Reznick, A. Z. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.12.031 · Cited by 258 · see citing works
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Zhou, J., Liu, B., Liang, C., Li, Y., & Song, Y.-H. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.03.002 · Cited by 172 · see citing works
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Fricker, M., Deane, A., & Hansbro, P. M. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.909805 · Cited by 169 · see citing works
“reported loss of muscle mass and function and linked this to increased systemic release of TNF-a causing the suppression of oxygen transport to muscle and increases in atrophy-related genes MuRF1 and Atrogin-1 [128].”
BackgroundMolecular Mechanisms of Neuroinflammation in Aging and Alzheimer’s Disease Progression
Andronie-Cioară, F. L., Ardelean, A. I., Nistor-Cseppento, C. D., Jurcău, A., Jurcău, M. C., Pașcalău, N., & Marcu, F. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031869 · Cited by 164 · see citing works
Morris, G., Berk, M., Gałecki, P., Walder, K. R., & Maes, M. H. J. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9090-9 · Cited by 160 · see citing works
“Given that elevated levels of TNFα leads to the downregulation of PGC-1α [265, 266], it is tempting to speculate that”
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LANGEN, R. C. J., Gosker, H. R., Remels, A. H. V., & Schols, A. M. W. J. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.06.015 · Cited by 159 · see citing works
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“Our findings are in line with the results of previous studies using nose-only exposure (Takubo et al., 2002; Guerassimov et al., 2004; Ardite et al., 2006; Barreiro et al., 2010) or a whole-body exposure system (De Paepe et al., 2008; Gosker et al., 2009; Tang et al., 2010).”
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Stevenson, C. S., & Birrell, M. A. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.10.008 · Cited by 112 · see citing works
Natural products, PGC-1 , and Duchenne muscular dystrophy
Süntar, I. P., Sureda, A., Belwal, T., Sanches-Silva, A. T., Vacca, R. A., Tewari, D., Sobarzo‐Sánchez, E., Nabavi, S. F., Shirooie, S., Dehpour, A. R., et al. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.01.001 · Cited by 103 · see citing works
Greulich, T., Nell, C., Koepke, J., Fechtel, J., Franke, M., Schmeck, B., Haid, D., Apelt, S., Filipovic, S., Kenn, K., et al. (2014) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-14-60 · Cited by 93 · see citing works
Chen, X., Guo, Y., Jia, G., Liu, G., Zhao, H. Y., & Huang, Z. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.08.007 · Cited by 90 · see citing works
Skeletal myofiber VEGF is essential for the exercise training response in adult mice
Delavar, H., Nogueira, L., Wagner, P. D., Hogan, M. C., METZGER, D., & Breen, E. C. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00522.2013 · Cited by 89 · see citing works
Self-citationMain Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting
Henrot, P., Dupin, I., Schilfarth, P., Esteves, P., Blervaque, L., Zysman, M., Gouzi, F., Hayot, M., Pomiès, P., & Berger, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076454 · Cited by 85 · see citing works
“Other models tend to corroborate in vitro data, such as a mouse model exposed to CS and exhibiting increased circulating TNF-α levels, which were correlated to detrimental outcomes such as muscle mass, decreased capillarization, and increased catabolism [41].”
Meyer, A., Zoll, J., Charles, A. L., Charloux, A., de Blay, F., Diemunsch, P., Sibilia, J., Piquard, F., & Geny, B. (2013) · Experimental Physiology · doi:10.1113/expphysiol.2012.069468 · Cited by 90 · see citing works
“In animals, exposure to tobacco smoke can decrease 3-hydroxyacyl-CoA dehydrogenase activity, CS activity and PGC-1α mRNA expression in skeletal muscle (Tang et al. 2010) as well as mitochondrial respiration (Gvozdjáková et al. 1992) in cardiomyocytes.”
BackgroundInfluentialStructural alterations of skeletal muscle in copd
Mathur, S., Brooks, D., & Carvalho, C. R. F. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00104 · Cited by 81 · see citing works
“Tobacco smoke may also act on muscle mitochondria through an increased expression of tumor necrosis factor-α (Tang et al., 2010).”
BackgroundSeiler, M., Bowen, T. S., Rolim, N. P. L., Dieterlen, M., Werner, S., Hoshi, T., Fischer, T., Mangner, N., Linke, A. H.-P., Schuler, G. C., et al. (2016) · Circulation Heart Failure · doi:10.1161/circheartfailure.116.003027 · Cited by 75 · see citing works
Identification of possible cigarette smoke constituents responsible for muscle catabolism
Rom, O., Kaisari, S., Aizenbud, D., & Reznick, A. Z. (2012) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-012-9299-4 · Cited by 73 · see citing works
The TWEAK-Fn14 Pathway: A Potent Regulator of Skeletal Muscle Biology in Health and Disease
Tajrishi, M. M., Zheng, T. S., Burkly, L., & Kumar, A. (2013) · Cytokine & growth factor reviews · doi:10.1016/j.cytogfr.2013.12.004 · Cited by 60 · see citing works
“Furthermore, there are also reports that TNF-a, a structural homologue of TWEAK, inhibits PGC-1a in skeletal muscle and other cell types [51,52].”
TNF-α impairs regulation of muscle oxidative phenotype: implications for cachexia?
Remels, A. H. V., Gosker, H. R., Schrauwen, P., Hommelberg, P. P. H., Sliwinski, P., Polkey, M., Galdiz, J., Wouters, E. F. M., Langen, R. C. J., & Schols, A. M. W. J. (2010) · The FASEB Journal · doi:10.1096/fj.09-150714 · Cited by 122 · see citing works
Obesity and Diabetes Mediated Chronic Inflammation: A Potential Biomarker in Alzheimer’s Disease
Khan, M. S. H., & Hegde, V. K. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10020042 · Cited by 64 · see citing works
Time course of cigarette smoke-induced changes of systemic inflammation and muscle structure
Krüger, K., Dischereit, G., Seimetz, M., Wilhelm, J., Weißmann, N., & Mooren, F. C. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00074.2015 · Cited by 56 · see citing works
Boeselt, T., Nell, C., Lütteken, L., Kehr, K., Koepke, J., Apelt, S., Veith, M., Beutel, B., Spielmanns, M., Greulich, T., et al. (2017) · Respiration · doi:10.1159/000464139 · Cited by 56 · see citing works
Regional skeletal muscle remodeling and mitochondrial dysfunction in right ventricular heart failure
Wüst, R. C. I., Myers, D. S., Stones, R., Benoîst, D., Robinson, P. A., Boyle, J. P., Peers, C., White, E., & Rossiter, H. B. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00653.2011 · Cited by 54 · see citing works
Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology
Eisele, P. S., & Handschin, C. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0406-4 · Cited by 53 · see citing works
“inhibition of oxidative phosphorylation is dependent on NF-B [291, 292].”
BackgroundInfluentialFerrari, R., Caram, L., Faganello, M. M., Sanchez, F. F., Tanni, S. É., & Godoy, I. (2015) · International Journal of COPD · doi:10.2147/copd.s85954 · Cited by 52 · see citing works
Alterations in Skeletal Muscle Cell Homeostasis in a Mouse Model of Cigarette Smoke Exposure
Caron, M., Morissette, M. C., Thériault, M., Nikota, J. K., Stämpfli, M. R., & Debigaré, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066433 · Cited by 53 · see citing works
Luan, A., Tang, F., Yang, Y., Lü, M., Wang, H., & Zhang, Y. (2015) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2015.03.014 · Cited by 51 · see citing works
Sukari, A. W., Muqbil, I., Mohammad, R. M., Philip, P. A., & Azmi, A. S. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2016.01.002 · Cited by 50 · see citing works
SS-31 attenuates TNF-α induced cytokine release from C2C12 myotubes
Lightfoot, A. P., Sakellariou, G. K., Nye, G., McArdle, F., Jackson, M. J., Griffiths, R. D., & McArdle, A. (2015) · Redox Biology · doi:10.1016/j.redox.2015.08.007 · Cited by 46 · see citing works
The TWEAK-Fn14 System: Breaking the Silence of Cytokine-Induced Skeletal Muscle Wasting
Bhatnagar, S., & Kumar, A. (2012) · Current molecular medicine · doi:10.2174/156652412798376107 · Cited by 45 · see citing works
Nogueira, L., Trisko, B. M., Lima‐Rosa, F. L., Jackson, J., Lund‐Palau, H., Yamaguchi, M., & Breen, E. C. (2018) · The Journal of Physiology · doi:10.1113/jp275888 · Cited by 44 · see citing works
“decrease in phospho-Akt) have been shown for skeletal muscles obtained from mice treated with cigarette smoke before the development of COPD (2 months of CS treatment; Tang et al. 2010).”
BackgroundResultInfluentialSelf-citationVyas, C. M., Ogata, S., Reynolds, C. F., Mischoulon, D., Chang, G., Cook, N. R., Manson, J. E., Crous‐Bou, M., Vivo, I. D., & Okereke, O. I. (2020) · PLoS ONE · doi:10.1371/journal.pone.0237235 · Cited by 44 · see citing works
Smoking cessation‐related weight gain—beneficial effects on muscle mass, strength and bone health
Rom, O., Reznick, A. Z., Keidar, Z., Karkabi, K., & Aizenbud, D. (2014) · Addiction · doi:10.1111/add.12761 · Cited by 41 · see citing works
Huang, B., Gao, Y., Shu, X., Wen, W., Yang, G., Li, G., Courtney, R., Ji, B., Li, H., Purdue, M. P., et al. (2014) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-14-0297 · Cited by 43 · see citing works
“sure to cigarette smoke and alcohol may decrease expression of peroxisomeproliferator activated receptor-gamma (PPAR-g)-coactivator 1 alpha (PGC-1a),which is involved inmitochondrial biogenesis (30, 31).”
BackgroundTWEAK promotes exercise intolerance by decreasing skeletal muscle oxidative phosphorylation capacity
Sato, S., Ogura, Y., Mishra, V. K., Shin, J. S., Bhatnagar, S., Hill, B. G., & Kumar, A. (2013) · Skeletal Muscle · doi:10.1186/2044-5040-3-18 · Cited by 40 · see citing works
Preclinical murine models of Chronic Obstructive Pulmonary Disease
Vlahos, R., & Bozinovski, S. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.029 · Cited by 38 · see citing works
Chen, X., Luo, X., Chen, D., Yu, B., He, J., & Huang, Z. (2019) · British Journal Of Nutrition · doi:10.1017/s000711451900309x · Cited by 39 · see citing works
Scott, I. C., Tomlinson, W., Walding, A., Isherwood, B. J., & Dougall, I. G. (2013) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-012-0097-z · Cited by 37 · see citing works
Greulich, T., Kehr, K., Nell, C., Koepke, J., Haid, D., Koehler, U., Koehler, K., Filipovic, S., Kenn, K., Vogelmeier, C. F., et al. (2014) · Respiratory Research · doi:10.1186/1465-9921-15-36 · Cited by 34 · see citing works
Basic, V., Roxlau, E. T., Elmabsout, A. A., Yao, H., Rahman, I., Sirsjö, A., & Abdel‐Halim, S. M. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00007.2012 · Cited by 35 · see citing works
Exercise Training Reverses Extrapulmonary Impairments in Smoke-exposed Mice
Bowen, T. S., Aakerøy, L., Eisenkolb, S., KUNTH, P., Bækkerud, F. H., Wohlwend, M., Berre, A. M. O., FISCHER, T., Wisløff, U., Schuler, G., et al. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001195 · Cited by 34 · see citing works
Dobric, A., Luca, S. N. D., Spencer, S. J., Bozinovski, S., Saling, M. M., McDonald, C. F., & Vlahos, R. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108017 · Cited by 34 · see citing works
Hansen, M. J., Chen, H., Jones, J. E. C., Langenbach, S. Y., Vlahos, R., Gualano, R. C., Morris, M. J., & Anderson, G. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080471 · Cited by 34 · see citing works
Ojo, O. O., Lagan, A. L., Rajendran, V., Spanjer, A. I. R., Chen, L., Sohal, S. S., Heijink, I. H., Jones, R., Maarsingh, H., & Hackett, T. (2014) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2014.04.004 · Cited by 31 · see citing works
Chronic aryl hydrocarbon receptor activity phenocopies smoking‐induced skeletal muscle impairment
Thome, T., Míguez, K., Willms, A. J., Burke, S., Chandran, V., de Souza, A. R., Fitzgerald, L. F., Baglole, C. J., Anagnostou, M., Bourbeau, J., et al. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12826 · Cited by 32 · see citing works
Superoxide release from contracting skeletal muscle in pulmonary TNF-α overexpression mice
Zuo, L., Hallman, A. H., Roberts, W. J., Wagner, P. D., & Hogan, M. C. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00425.2013 · Cited by 32 · see citing works
Self-citationRyan, K. M., Patterson, I., & McLoughlin, D. M. (2018) · Psychological Medicine · doi:10.1017/s0033291718002556 · Cited by 30 · see citing works
“We adjusted for potential variance owing to body mass index (BMI; kg/m2) and smoking, which have previously been associated with PGC-1α and mood (Kendler et al., 1993; Simon et al., 2006; Tang et al., 2010; Sajan et al., 2015).”
MethodAjime, T., Serré, J., Wüst, R., Messa, G. A. M., Poffé, C., Swaminathan, A., Maes, K., Janssens, W., Troosters, T., Degens, H., et al. (2020) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntaa016 · Cited by 24 · see citing works
Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice
Wang, H., Kuusela, S., Rinnankoski‐Tuikka, R., Dumont, V., Bouslama, R., Ramadan, U. A., Waaler, J., Linden, A.-M., Chi, N., Krauss, S. J. K., et al. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-0573-z · Cited by 30 · see citing works
Role of acute exacerbations in skeletal muscle impairment in COPD
Gosker, H. R., LANGEN, R. C. J., & Simons, S. O. (2020) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2021.1843429 · Cited by 29 · see citing works
Zeng, Z., Chen, X., Huang, Z., Chen, D., He, J., Chen, H., Yu, J., Luo, Y., Luo, J., Zheng, P., et al. (2020) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2020.114499 · Cited by 28 · see citing works
Sinha-Hikim, I., Friedman, T., Shin, C.-S., Lee, D. L., Ivey, R., & Sinha-Hikim, A. (2014) · Endocrinology · doi:10.1210/en.2013-1795 · Cited by 30 · see citing works
Interaction between Physical Activity and Smoking on Lung, Muscle, and Bone in Mice
Cielen, N., Maes, K., Heulens, N., Troosters, T., Carmeliet, G., Janssens, W., & Gayan‐Ramirez, G. (2015) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2015-0181oc · Cited by 26 · see citing works
“Additionally, the shift towards a more glycolytic profile in both muscles, as shown before (23, 33, 34), did not result in impaired maximal exercise capacity, which is in agreement with other mouse studies (17, 34) but contrasting with the data in patients with COPD (35).”
ResultJia, A., Feng, J., Zhang, M. H., Chang, Y., Li, Z., Hu, C. H., Zhen, L., Zhang, S. S., & Peng, Q. Q. (2015) · Journal of Animal Science · doi:10.2527/jas.2015-9391 · Cited by 26 · see citing works
Impaired Exercise Capacity and Skeletal Muscle Function in a Mouse Model of Pulmonary Inflammation
Tang, K., Murano, G., Wagner, H., Nogueira, L., Wagner, P. D., Tang, A., Dalton, N. D., Gu, Y., Peterson, K. L., & Breen, E. C. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00607.2012 · Cited by 30 · see citing works
Self-citationNaeyer, H. D., Lamon, S., Russell, A. P., Everaert, I., Spaey, A. D., Vanheel, B., Taes, Y., & Derave, W. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-013-2800-y · Cited by 24 · see citing works
“Trim63/MuRF1 tang et al. (2010) tgg-AAA-cgc-tAt-ggA-gAA-cc Att-cgc-Agc-ctg-gAA-gAt-g nM_001039048”
BackgroundKnapp, A. E., Goldberg, D., Delavar, H., Trisko, B. M., Tang, K., Hogan, M. C., Wagner, P. D., & Breen, E. C. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00533.2015 · Cited by 23 · see citing works
“types, the majority (90%) of which are type IIb fibers (18, 39)], heart,”
BackgroundSelf-citationHafen, P. S., Law, A. S., Matias, C., Miller, S. G., & Brault, J. J. (2022) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00035.2022 · Cited by 23 · see citing works
Effects of Cigarette Smoke on Adipose and Skeletal Muscle Tissue: In Vivo and In Vitro Studies
Wang, L., van Iersel, L. E. J., Pelgrim, C. E., Lu, J., van Ark, I., Leusink-Muis, T., Gosker, H. R., LANGEN, R. C. J., Schols, A. M. W. J., Argilés, J. M. A., et al. (2022) · Cells · doi:10.3390/cells11182893 · Cited by 23 · see citing works
Chronic exposure to cigarette smoke causes extrapulmonary abnormalities in rats
Kamiide, Y., Furuya, M., Inomata, N., & Yada, T. (2015) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2015.02.016 · Cited by 22 · see citing works
Effect of pulmonary TNF-α overexpression on mouse isolated skeletal muscle function
Zuo, L., Nogueira, L., & Hogan, M. C. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00126.2011 · Cited by 21 · see citing works
Vitamin D deficiency impairs skeletal muscle function in a smoking mouse model
Cielen, N., Heulens, N., Maes, K., Carmeliet, G., Mathieu, C., Janssens, W., & Gayan‐Ramirez, G. (2016) · Journal of Endocrinology · doi:10.1530/joe-15-0491 · Cited by 21 · see citing works
“In mice, smoking downregulates PGC1-α (Tang et al. 2010) which serves as a co-activator for VDR (Savkur et al. 2005) thereby affecting skeletal muscle function.”
BackgroundAnimal Models of Chronic Obstructive Pulmonary Disease Exacerbations: A Review of the Current Status
Oliveira, M. V. (2016) · Journal of Biomedical Sciencies · doi:10.4172/2254-609x.100022 · Cited by 20 · see citing works
“…to CS 5 days/week for 6 months Pulmonary inflammation, weight loss, and reduction in type IIA oxidative fiber proportion in the soleus muscle Tang et al., 2010 [56] C57BL/6 mice Animals exposed to CS daily for 8 or 16 weeks Weight loss, reduction in citrate synthase and beta-hydroxyacyl CoA…”
MethodFitzgerald, L. F., Lackey, J. B., Moussa, A., Shah, S., Castellanos, A. M., Khan, S., Schonk, M. M., Thome, T., Salyers, Z. R., Jakkidi, N. R., et al. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13439 · Cited by 18 · see citing works
“22 In addition to measuring the EDL muscle, Rinaldi et al. 21 also performed measures using the slow twitch soleus muscle where they reported signi fi cant decreases in speci fi c force and elevated fatiguability.”
MethodBasic, V., Jacobsen, A. V., Sirsjö, A., & Abdel‐Halim, S. M. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1776 · Cited by 17 · see citing works
Development and Functions of Mitochondria in Early Life
Maheshwari, A., Peng, J., Ramatchandirin, B., Pearah, A., & He, L. (2022) · Newborn · doi:10.5005/jp-journals-11002-0013 · Cited by 16 · see citing works
Blockade of 4-1BB and 4-1BBL Interaction Reduces Obesity-Induced Skeletal Muscle Inflammation
Ngoc, H. L., Kim, C.-S., Tu, T. H., Choi, H., Kim, B.-S., Kawada, T., Goto, T., Park, T., Park, J. H. Y., & Yu, R. (2013) · Mediators of Inflammation · doi:10.1155/2013/865159 · Cited by 16 · see citing works
“Hindawi Publishing Corporation Mediators of Inflammation Volume 2013, Article ID 865159, 10 pages http://dx.doi.org/10.1155/2013/865159”
BackgroundInfluentialKamiide, Y., Inomata, N., Furuya, M., & Yada, T. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.02.049 · Cited by 16 · see citing works
Tanaka, M., Sugimoto, K., Fujimoto, T., Xie, K., Takahashi, T., Akasaka, H., Yasunobe, Y., Takeya, Y., Yamamoto, K., Hirabayashi, T., et al. (2020) · The FASEB Journal · doi:10.1096/fj.202001330r · Cited by 10 · see citing works
Lu, J., Wang, Q., Xie, L., Zhang, Q., & Sun, S. (2017) · Tobacco Induced Diseases · doi:10.1186/s12971-017-0148-5 · Cited by 14 · see citing works
“Cigarette smoking is among the most common causes of COPD, as demonstrated in mice exposed to cigarette smoke daily for 8 weeks, whereby a 157% increase in serum tumor necrosis factor (TNF)-α, accompanied by significant decreases in the levels of peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) mR…”
BackgroundShioya-Yamada, M., Shimada, K., Nishitani-Yokoyama, M., Sai, E., Takeno, K., Tamura, Y., Watada, H., Kawamori, R., Daida, H., & Kawai, S. (2018) · Journal of Clinical Medicine Research · doi:10.14740/jocmr3403w · Cited by 12 · see citing works
“In addition, TNF-α may mediate the down-regulation of peroxisome proliferator-activated receptor gamma coactivator-1α, resulting in impaired skeletal muscle function [24].”
BackgroundDiabetes Mellitus: A Path to Amnesia, Personality, and Behavior Change
Ahmad, R., Chowdhury, K., Kumar, S., Irfan, M., Reddy, G. S., Akter, F., Jahan, D., & Haque, M. (2022) · Biology · doi:10.3390/biology11030382 · Cited by 14 · see citing works
Liu, C., Zhang, Q., Liu, T., Zhang, Q., Song, M., Ruan, G., Lin, S., Wang, Z., Zheng, X., Chen, Y., et al. (2023) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13370 · Cited by 12 · see citing works
Huang, D., Ma, Z., He, Y., Xiao, Y., Luo, H., Liang, Q., Zhong, X., Bai, J., & He, Z. (2017) · Oncotarget · doi:10.18632/oncotarget.18089 · Cited by 11 · see citing works
“More importantly, TNF-α can inhibit PGC-1α expression, leading to vascular and myocyte dysfunction [19] and IL-8 has been associated with increased resting energy expenditure and recruits inflammatory infiltrates [20].”
BackgroundTanaka, M., Morifuji, T., Sugimoto, K., Akasaka, H., Fujimoto, T., Yoshikawa, M., Nakanishi, R., Kondo, H., & Fujino, H. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00366.2021 · Cited by 11 · see citing works
Nogueira, L., Zemljic‐Harpf, A. E., Yusufi, R., Ranjbar, M., Susanto, C., Tang, K., Mahata, S. K., Jennings, P. A., & Breen, E. C. (2022) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00314.2021 · Cited by 10 · see citing works
Self-citationNogueira, L., Gilmore, N. K., & Hogan, M. C. (2022) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00861.2021 · Cited by 10 · see citing works
The acute effects of cigarette smoke exposure on muscle fiber type dynamics in rats
Cheung, K., Fung, T. K. H., Mak, J., Cheung, S.-Y., He, W., Leung, J. W.-H., Lau, B. W.-M., & Ngai, S. P. C. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233523 · Cited by 9 · see citing works
Cannon, D. T., Rodewohl, L., Adams, V., Breen, E. C., & Bowen, T. S. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00779.2018 · Cited by 8 · see citing works
Self-citationTang, K., Gu, Y., Dalton, N. D., Wagner, H. E., Peterson, K. L., Wagner, P. D., & Breen, E. C. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25097 · Cited by 8 · see citing works
“Extensor digitorum longus (EDL) and soleus were removed and electrically stimulated to contract in vitro (EDL: 16V, 300ms train duration, 0.5ms pulse duration; soleus: 16V, 500ms train duration, 0.5ms pulse duration) in Tyrode’s solution, pH 7.4 as previously described (Tang et al., 2010).”
MethodInfluentialSelf-citationCorreia, T. M. L., de Almeida, A. A., da Silva, D. A., Coqueiro, R. D. S., Pires, R. A., de Magalhães, A. C. M., Queiroz, R. F., Brito, L. L., Marques, L. M., Machado, M., et al. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.109913 · Cited by 7 · see citing works
Impacts of Cigarette Smoke (CS) on Muscle Derangement in Rodents—A Systematic Review
He, W., Ngai, S. P. C., Cheung, K., Lau, B. W.-M., Sánchez-Vidaña, D. I., & Pang, M. Y. C. (2022) · Toxics · doi:10.3390/toxics10050262 · Cited by 6 · see citing works
“Six different skeletal muscle groups were examined, including the quadriceps [24], rectus femoris [25], gastrocnemius [9,23,25,26], soleus [23,26,29,30,32], EDL [29,30], tibialis [26], plantaris [26], and respiratory muscles such as the diaphragm [9] (Table 4).”
BackgroundMethodInfluentialChen, X., Chen, L., Qin, Y., Mao, Z., Jia, G., Zhao, H. Y., Liu, G., & Huang, Z. (2022) · Animal Biotechnology · doi:10.1080/10495398.2022.2078725 · Cited by 6 · see citing works
“Previous studied have found that the activities of metabolic enzyme (such as SDH, MDH and LDH) can indirectly reflect the transformation of muscle fiber types.(13,14) Taken together, these results suggest that LT can promote the transformation of muscle fiber types from slow oxidative to fast glycolytic, which is cons…”
ResultAnimal Models of Chronic Obstructive Pulmonary Disease
Chow, L. S. N., Smith, D., Chokshi, K., Ezegbunam, W., Charoenpong, P., Foley, K., Cargill, A., & Geraghty, P. M. (2018) · InTech eBooks · doi:10.5772/intechopen.70262 · Cited by 6 · see citing works
Wang, F., Sun, W., Liu, G., Jia, G., Zhao, H. Y., Chen, X., Wu, C., & Wang, J. (2022) · Animal Biotechnology · doi:10.1080/10495398.2022.2136679 · Cited by 5 · see citing works
Decker, S. T., Alexandrou-Majaj, N., & Layec, G. (2023) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2023.148973 · Cited by 5 · see citing works
Rom, O., Kaisari, S., Aizenbud, D., & Reznick, A. Z. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-6627-3_4 · Cited by 4 · see citing works
Sulaeman, A., Fine, J. M., de Vargas‐Machuca, A., Vitorino, S. A., Wagner, P. D., Fruttiger, M., & Breen, E. C. (2020) · Experimental Physiology · doi:10.1113/ep088924 · Cited by 4 · see citing works
Self-citationPasserieux, E., Desplanche, E., Alburquerque, L., Wynands, Q., Bellanger, A., Virsolvy, A., Gouzi, F., Cazorla, O., BOURDIN, A. A., Hayot, M., et al. (2024) · Acta Physiologica · doi:10.1111/apha.14165 · Cited by 4 · see citing works
“34,35 However, our data showed a decrease in the capillary/fiber ratio in parallel with fiber atrophy only for type 1 muscle fibers of the fast-twitch muscle EDL.”
Background
- Authors
- Tang, K., Wagner, P. D., & Breen, E. C.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Tang, Kechun
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2009-10-26
- Volume
- 222
- Issue
- 2
- Pages
- 320-327
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- PMC
- PMC5831677
- OpenAlex
- W2080048804
- Cited by
- 125
- References
- 40
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 5 · 2023: 7 · 2022: 11 · 2021: 4 · 2020: 11 · 2019: 3 · 2018: 6 · 2017: 8 · 2016: 9 · 2015: 14 · 2014: 13 · 2013: 13 · 2012: 5
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (5R01 HL 84281, R01HL084281, P01HL091830)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Keywords
- cigarette smoke exposure, TNF-α, PGC-1α, skeletal muscle dysfunction, chronic obstructive pulmonary disease, oxidative stress, vascular endothelial growth factor, muscle fiber type transition, atrogin-1, MuRF1, muscle atrophy, exercise endurance, muscle fatigue, soleus muscle, EDL, muscle vascularization, inflammatory cytokines
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Animals, Capillaries, Cell Line, Glycolysis, Hindlimb, Male, Mice, Inbred C57BL, Muscle Contraction, Muscle Proteins, Muscular Atrophy, Oxidation-Reduction, RNA, Messenger, Smoking, Time Factors, Tobacco Smoke Pollution, Transcription Factors, Tumor Necrosis Factor-alpha, Trans-Activators, Down-Regulation, Up-Regulation, Exercise Tolerance, Muscle, Skeletal, Muscle Fibers, Fast-Twitch, Muscle Fibers, Slow-Twitch, Muscle Fatigue, Inhalation Exposure, Vascular Endothelial Growth Factor A, Ubiquitin-Protein Ligases, SKP Cullin F-Box Protein Ligases, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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