The DOI matches its Crossref record; 66 of the 67 references it cites were found in a registry or an index.
Human Brain Parenchymal Microglia Express CD14 and CD45 and are Productively Infected by HIV‐1 in HIV‐1 Encephalitis
Open accessAbstract
Microglia are endogenous brain macrophages that show distinct phenotypes such as expression of myeloid antigens, ramified morphology, and presence within the neural parenchyma. They play significant roles in a number of human CNS diseases including AIDS dementia. Together with monocytederived (perivascular) macrophages, microglia represent a major target of HIV‐1 infection. However, a recent report challenged this notion based on findings in SIV encephalitis. This study concluded that perivascular macrophages can be distinguished from parenchymal microglial cells by their expression of CD14 and CD45, and that macrophages, but not microglia, are productively infected in SIV and HIV encephalitis. To address whether parenchymal microglia are productively infected in HIV encephalitis, we analyzed expression of CD14, CD45 and HIV‐1 p24 in human brain. Microglia were identified based on their characteristic ramified morphology and location in the neural parenchyma. We found that parenchymal microglia are CD14+ (activated), CD45+ (resting and activated), and constitute approximately two thirds of the p24+ cells in HIV encephalitis cases. These results demonstrate that microglia are major targets of infection by HIV‐1, and delineate possible differences between HIVE and SIVE. Because productively infected tissue macrophages serve as the major viral reservoir, these findings have important implications for AIDS.
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“In cases where the infection was diffuse [23], ramified glial cells had enhanced TSPO positivity, most of which were clearly identifiable as activated microglia.”
From Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain (2009) · cites this paper as [23]
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Cites
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Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism
Block, M. L., & Hong, J.-S. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.004 · Cited by 1,557
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Galea, I. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00757-x · Cited by 807
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Metadata
- Authors
- Cosenza;, M. A., Zhao;, M., Si;, Q., & Lee, S. C.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Lee, Sunhee C.
- Venue
- Brain Pathology
- Publisher
- Wiley
- Published
- 2002-10
- Volume
- 12
- Issue
- 4
- Pages
- 442-455
- ISSN
- 1015-6305 (ISSN-L)
- 1750-3639
- PMC
- PMC8095974
- OpenAlex
- W1990773400
- Cited by
- 238
- References
- 67
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 9 · 2023: 9 · 2022: 10 · 2021: 17 · 2020: 10 · 2019: 13 · 2018: 13 · 2017: 12 · 2016: 8 · 2015: 4 · 2014: 18 · 2013: 18 · 2012: 5
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ai044641-04)
- National Institute of Mental Health (R01MH055477, R24-MH-59724, R24MH059724, MH 55477)
- National Institute of Allergy and Infectious Diseases (AI44641)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
- Keywords
- microglia, HIV-1 encephalitis, CD14, CD45, perivascular macrophages, SIV encephalitis, HIV-1 p24 antigen, HIV-associated dementia, viral reservoir, brain macrophages
- MeSH terms
- Adult, Antigens, Surface, Brain, Cells, Cultured, Female, Fetus, Humans, Immunohistochemistry, Macrophages, Male, Middle Aged, Monocytes, Biomarkers, HIV-1, AIDS Dementia Complex, HIV Core Protein p24, Leukocyte Common Antigens, Microglia, Lipopolysaccharide Receptors, Cell Size
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