Cited by 238HIV Research and TreatmentNeuroinflammation and Neurodegeneration MechanismsInfectious Diseases and Tuberculosis

The DOI matches its Crossref record; 66 of the 67 references it cites were found in a registry or an index.

Human Brain Parenchymal Microglia Express CD14 and CD45 and are Productively Infected by HIV‐1 in HIV‐1 Encephalitis

Open access

Cosenza;, Melissa A., Zhao;, Meng‐Liang, Si;, Qiusheng, Lee, Sunhee C.·2002·Brain Pathology

DOI 10.1111/j.1750-3639.2002.tb00461.xPMC PMC8095974

Open this paper in CoChat — free account

Abstract

Microglia are endogenous brain macrophages that show distinct phenotypes such as expression of myeloid antigens, ramified morphology, and presence within the neural parenchyma. They play significant roles in a number of human CNS diseases including AIDS dementia. Together with monocytederived (perivascular) macrophages, microglia represent a major target of HIV‐1 infection. However, a recent report challenged this notion based on findings in SIV encephalitis. This study concluded that perivascular macrophages can be distinguished from parenchymal microglial cells by their expression of CD14 and CD45, and that macrophages, but not microglia, are productively infected in SIV and HIV encephalitis. To address whether parenchymal microglia are productively infected in HIV encephalitis, we analyzed expression of CD14, CD45 and HIV‐1 p24 in human brain. Microglia were identified based on their characteristic ramified morphology and location in the neural parenchyma. We found that parenchymal microglia are CD14+ (activated), CD45+ (resting and activated), and constitute approximately two thirds of the p24+ cells in HIV encephalitis cases. These results demonstrate that microglia are major targets of infection by HIV‐1, and delineate possible differences between HIVE and SIVE. Because productively infected tissue macrophages serve as the major viral reservoir, these findings have important implications for AIDS.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1750-3639.2002.tb00461.x

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein
Wright, S. D., Ramos, R., Tobias, P. S., Ulevitch, R. J., & Mathison, J. C. (1990) · Science · doi:10.1126/science.1698311 · Cited by 3,996
Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
Lawson, L. J., Perry, V. H., Dri, P., & Gordon, S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90229-w · Cited by 2,045
The AIDS dementia complex: I. Clinical features
NAVIA, B. A., Jordan, B. D., & Price, R. W. (1986) · Annals of Neurology · doi:10.1002/ana.410190602 · Cited by 1,667
Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
Hickey, W. F., & Kimura, H. (1988) · Science · doi:10.1126/science.3276004 · Cited by 1,466
Receptor-Dependent Mechanisms of Cell Stimulation by Bacterial Endotoxin
Ulevitch, R. J., & Tobias, P. S. (1995) · Annual Review of Immunology · doi:10.1146/annurev.iy.13.040195.002253 · Cited by 1,442 · cited 1×
“CD14 is the LPS receptor and renders the cells exquisitely sensitive to the actions of LPS, as is the case for microglia (35, 55, 63).”
Background
The AIDS dementia complex: II. Neuropathology
NAVIA, B. A., Cho, E., Petito, C. K., & Price, R. W. (1986) · Annals of Neurology · doi:10.1002/ana.410190603 · Cited by 1,268
Microglia: Intrinsic immuneffector cell of the brain
Gehrmann, J., Matsumoto, Y., & Kreutzberg, G. W. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(94)00015-h · Cited by 1,111
CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia
He, J., Chen, Y., Farzan, M., Choe, H., Öhagen, Å., Gartner, S., Busciglio, J. A., Yang, X., Hofmann, W., Newman, W., et al. (1997) · Nature · doi:10.1038/385645a0 · Cited by 915
Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta.
Lee, S. C., Liu, W., Dickson, D. W., Brosnan, C., & Berman, J. (1993) · Journal of Immunology · doi:10.4049/jimmunol.150.7.2659 · Cited by 850
Self-citation
Macrophages and microglia in the nervous system
Perry, V. H., & Gordon, S. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90110-5 · Cited by 747

Show all 67 references

Research works printed but not linked: 3

Dickson DW, 1997, Microglia. Textbook of neuropathology, 165
Dickson DW, 1991, Biology of disease: microglia in human disease, with an emphasis on the aquired immunodeficiency syndrome, Lab Invest, 64, 135
Lee SC, 1992, Characterization of human fetal dissociated CNS cultures with an emphasis on microglia, Lab Invest, 67, 465

Sorted by citations

Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism
Block, M. L., & Hong, J.-S. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.004 · Cited by 1,557
The neuropathogenesis of AIDS
González‐Scarano, F., & Martín‐García, J. (2005) · Nature reviews. Immunology · doi:10.1038/nri1527 · Cited by 1,093
The blood–brain barrier in systemic infection and inflammation
Galea, I. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00757-x · Cited by 807
Role of Microglia in Central Nervous System Infections
Rock, R. B., Gekker, G., Hu, S., Sheng, W. S., Cheeran, M., Lokensgard, J. R., & Peterson, P. K. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.4.942-964.2004 · Cited by 723
Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain
Cosenza‐Nashat, M., Zhao, M. ‐., Suh, H. ‐., Morgan, J., Natividad, R., Morgello, S., & Lee, S. C. (2009) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2008.01006.x · Cited by 459
Self-citation
Microglial Cells: The Main HIV-1 Reservoir in the Brain
Wallet, C., Rovere, M. D., Assche, J. V., Daouad, F., Wit, S. D., Gautier, V., Mallon, P. W. G., Marcello, A., Lint, C. M. V., Rohr, O., et al. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00362 · Cited by 378
Cellular Reservoirs of HIV-1 and their Role in Viral Persistence
Alexaki, A., Liu, Y., & Wigdahl, B. L. (2008) · Current HIV Research · doi:10.2174/157016208785861195 · Cited by 357
Extensive astrocyte infection is prominent in human immunodeficiency virus–associated dementia
Churchill, M. J., Wesselingh, S., Cowley, D., Pardo, C., McArthur, J., Brew, B., & Gorry, P. (2009) · Annals of Neurology · doi:10.1002/ana.21697 · Cited by 359
Illuminating viral infections in the nervous system
McGavern, D. B., & Kang, S. S. (2011) · Nature Reviews Immunology · doi:10.1038/nri2971 · Cited by 281
Human Immunodeficiency Virus Infection of Human Astrocytes Disrupts Blood-Brain Barrier Integrity by a Gap Junction-Dependent Mechanism
Eugenín, E. A., Clements, J. E., Zink, M. C., & Berman, J. W. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1460-11.2011 · Cited by 253
The contribution of monocyte infection and trafficking to viral persistence, and maintenance of the viral reservoir in HIV infection
Crowe, S. M., Zhu, T., & Müller, W. A. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0503204 · Cited by 255
Dynamic structural remodelling of microglia in health and disease: A review of the models, the signals and the mechanisms
Walker, F. R., Beynon, S. B., Jones, K., Zhao, Z., Kongsui, R., Cairns, M. J., & Nilsson, M. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.010 · Cited by 243
CD163 Identifies Perivascular Macrophages in Normal and Viral Encephalitic Brains and Potential Precursors to Perivascular Macrophages in Blood
Kim, W.-K., Alvarez, X., Fisher, J., Bronfin, B., Westmoreland, S., McLaurin, J., & Williams, K. (2006) · The American Journal of Pathology · doi:10.2353/ajpath.2006.050215 · Cited by 225
Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators
Suh, H.-S., Zhao, M.-L., Derico, L., Choi, N., & Lee, S. C. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-37 · Cited by 226
Self-citation
HIV-1 Latency in Monocytes/Macrophages
Kumar, A., Abbas, W., & Herbein, G. (2014) · Viruses · doi:10.3390/v6041837 · Cited by 214
LPS and IL‐1 differentially activate mouse and human astrocytes: Role of CD14
Tarassishin, L., Suh, H.-S., & Lee, S. C. (2014) · Glia · doi:10.1002/glia.22657 · Cited by 209
Self-citation
CNS Inflammation and Macrophage/Microglial Biology Associated with HIV-1 Infection
Yadav, A., & Collman, R. G. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9174-2 · Cited by 203
The Role of Macrophages in HIV-1 Persistence and Pathogenesis
Kruize, Z., & Kootstra, N. A. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02828 · Cited by 205
The role of microglia in viral encephalitis: a review
Chen, Z., Zhong, D., & Li, G. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1443-2 · Cited by 196
The importance of monocytes and macrophages in HIV pathogenesis, treatment, and cure
Campbell, J. H., Hearps, A. C., Martin, G. E., Williams, K. C., & Crowe, S. M. (2014) · AIDS · doi:10.1097/qad.0000000000000408 · Cited by 195
HIV-1 target cells in the CNS
Joseph, S., Arrildt, K. T., Sturdevant, C. B., & Swanstrom, R. I. (2014) · Journal of NeuroVirology · doi:10.1007/s13365-014-0287-x · Cited by 201
Compartmentalization and Clonal Amplification of HIV-1 Variants in the Cerebrospinal Fluid during Primary Infection
Schnell, G., Price, R. W., Swanstrom, R. I., & Spudich, S. (2009) · Journal of Virology · doi:10.1128/jvi.01863-09 · Cited by 161
Important role of microglia in HIV-1 associated neurocognitive disorders and the molecular pathways implicated in its pathogenesis
Borrajo, A., Spuch, C., Penedo, M. A., Olivares, J. M., & Agís‐Balboa, R. C. (2020) · Annals of Medicine · doi:10.1080/07853890.2020.1814962 · Cited by 150
Molecular Mechanisms of Microglial Motility: Changes in Ageing and Alzheimer’s Disease
Franco-Bocanegra, D. K., McAuley, C., Nicoll, J. A. R., & Boche, D. (2019) · Cells · doi:10.3390/cells8060639 · Cited by 147
Where does HIV hide? A focus on the central nervous system
Churchill, M. J., & Nath, A. (2013) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e32835fc601 · Cited by 145
Phenotyping primary human microglia: tight regulation of LPS responsiveness
Melief, J., Koning, N., Schuurman, K. G., Van De Garde, M. D. B., Smolders, J., Hoek, R. M., Van Eijk, M., Hamann, J., & Huitinga, I. (2012) · Glia · doi:10.1002/glia.22370 · Cited by 146
Retroviruses and amyotrophic lateral sclerosis
Alfahad, T. B., & Nath, A. (2013) · Antiviral Research · doi:10.1016/j.antiviral.2013.05.006 · Cited by 144
Repetitive mild traumatic brain injury augments tau pathology and glial activation in aged hTau mice
Ojo, J.-O., Mouzon, B., Greenberg, M. B., Bachmeier, C., Mullan, M., & Crawford, F. (2013) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3182814cdf · Cited by 166
Monocyte/macrophage traffic in HIV and SIV encephalitis
Kim, W., Corey, S. M., Alvarez, X. A., & Williams, K. C. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0503207 · Cited by 138
Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events
Bhaskar, K., Maphis, N. M., Xu, G., Varvel, N. H., Kokiko‐Cochran, O. N., Weick, J. P., Staugaitis, S. M., Cardona, A. E., Ransohoff, R. M., Herrup, K., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.10.007 · Cited by 141
Effect of human immunodeficiency virus on blood-brain barrier integrity and function: an update
Atluri, V. S. R., Hidalgo, M., Samikkannu, T., Kurapati, K. R. V., Jayant, R. D., Sagar, V., & Nair, M. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00212 · Cited by 130
Parenchymal accumulation of CD163+ macrophages/microglia in multiple sclerosis brains
Zhang, Z., Zhang, Z., Schittenhelm, J., Wu, Y., Meyermann, R., & Schluesener, H. J. (2011) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2011.06.006 · Cited by 124
The shifting patterns of HIV encephalitis neuropathology
Everall, I., Hansen, L. A., & Masliah, E. (2005) · Neurotoxicity Research · doi:10.1007/bf03033819 · Cited by 119
Is the central nervous system a reservoir of HIV-1?
Gray, L. R., Roche, M., Flynn, J. K., Wesselingh, S. L., Gorry, P. R., & Churchill, M. J. (2014) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000108 · Cited by 116
CD163, a Marker of Perivascular Macrophages, Is Up-Regulated by Microglia in Simian Immunodeficiency Virus Encephalitis after Haptoglobin-Hemoglobin Complex Stimulation and Is Suggestive of Breakdown of the Blood-Brain Barrier
Borda, J. T., Alvarez, X., Mohan, M., Hasegawa, A., Bernardino, A., Jean, S., Aye, P., & Lackner, A. A. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.070848 · Cited by 115
Quantitation of Productively Infected Monocytes and Macrophages of Simian Immunodeficiency Virus-Infected Macaques
Avalos, C. R., Price, S. L., Forsyth, E. R., Pin, J. N., Shirk, E. N., Bullock, B. T., Queen, S. E., Li, M., Gellerup, D. D., O’Connor, S. L., et al. (2016) · Journal of Virology · doi:10.1128/jvi.00290-16 · Cited by 114
HIV disorders of the brain; pathology and pathogenesis
Valle, L. D. (2006) · Frontiers in bioscience · doi:10.2741/1830 · Cited by 109
Epigenetic control of HIV-1 post integration latency: implications for therapy
Kumar, A., Darcis, G., Lint, C. M. V., & Herbein, G. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0137-6 · Cited by 108
Temporal evolution of microglia and α-synuclein accumulation following foetal grafting in Parkinson’s disease
Olanow, C. W., Savolainen, M., Chu, Y., Halliday, G. M., & Kordower, J. H. (2019) · Brain · doi:10.1093/brain/awz104 · Cited by 112
Host hindrance to HIV-1 replication in monocytes and macrophages
Bergamaschi, A., & Pancino, G. (2010) · Retrovirology · doi:10.1186/1742-4690-7-31 · Cited by 112
Human Immunodeficiency Virus (HIV)-Induced Neurotoxicity: Roles for the NMDA Receptor Subtypes
O’Donnell, L. A., Agrawal, A., Jordan‐Sciutto, K. L., Dichter, M. A., Lynch, D. R., & Kolson, D. L. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4617-05.2006 · Cited by 104
Cross-talk between microglia and neurons regulates HIV latency
Alvarez-Carbonell, D., Ye, F., Ramanath, N., García‐Mesa, Y., Knapp, P. E., Hauser, K. F., & Karn, J. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1008249 · Cited by 93
Human Immunodeficiency Virus Type 1 Infection Increases the In Vivo Capacity of Peripheral Monocytes To Cross the Blood-Brain Barrier into the Brain and the In Vivo Sensitivity of the Blood-Brain Barrier to Disruption by Lipopolysaccharide
Wang, H., Sun, J., & Goldstein, H. (2008) · Journal of Virology · doi:10.1128/jvi.00768-08 · Cited by 92
Regulation of ABC membrane transporters in glial cells: Relevance to the pharmacotherapy of brain HIV‐1 infection
Ronaldson, P. T., Persidsky, Y., & Bendayan, R. (2008) · Glia · doi:10.1002/glia.20725 · Cited by 92
Inhibition of Granulocyte-Macrophage Colony-Stimulating Factor Signaling and Microglial Proliferation by Anti-CD45RO: Role of Hck Tyrosine Kinase and Phosphatidylinositol 3-Kinase/Akt
Suh, H.-S., Kim, M.-O., & Lee, S. C. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.5.2712 · Cited by 90
Self-citation
Nef exosomes isolated from the plasma of individuals with HIV-associated dementia (HAD) can induce Aβ1–42 secretion in SH-SY5Y neural cells
Khan, M. B., Lang, M. J., Huang, M., Raymond, A., Bond, V. C., Shiramizu, B. T., & Powell, M. D. (2015) · Journal of NeuroVirology · doi:10.1007/s13365-015-0383-6 · Cited by 84
Myeloid Cell Interaction with HIV: A Complex Relationship
Rodrigues, V., Ruffin, N., Jouve, M. J., & Benaroch, P. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01698 · Cited by 81
HIV Neuroinfection and Alzheimer’s Disease: Similarities and Potential Links?
Canet, G., Dias, C., Gabelle, A., Simonin, Y., Gosselet, F., Marchi, N., Makinson, A., Tuaillon, É., de Perre, P. V., Givalois, L., et al. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00307 · Cited by 80
Drug Induced Increases in CNS Dopamine Alter Monocyte, Macrophage and T Cell Functions: Implications for HAND
Gaskill, P. J., Calderon, T. M., Coley, J. S., & Berman, J. W. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9443-y · Cited by 77
Neuroendocrine, neuroinflammatory and pathological outcomes of chronic stress: A story of microglial remodeling
Picard, K., St‐Pierre, M., Vecchiarelli, H. A., Bordeleau, M., & Tremblay, M. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.104987 · Cited by 79
Mechanism for the Establishment of Transcriptional HIV Latency in the Brain in a Simian Immunodeficiency Virus–Macaque Model
Barber, S. A., Gama, L., Dudaronek, J. M., Voelker, T., Tarwater, P. M., & Clements, J. E. (2006) · The Journal of Infectious Diseases · doi:10.1086/500983 · Cited by 77
Eradication of human immunodeficiency virus from brain reservoirs
Nath, A. (2014) · Journal of NeuroVirology · doi:10.1007/s13365-014-0291-1 · Cited by 77
Comparative analysis of human microglial models for studies of HIV replication and pathogenesis
Mohammad, A., Hammonds, J. E., Pujato, M. A., Mayhew, C. N., Roskin, K. M., & Spearman, P. W. (2020) · Retrovirology · doi:10.1186/s12977-020-00544-y · Cited by 78
Beneficial and detrimental functions of microglia during viral encephalitis
Waltl, I., & Kalinke, U. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.11.004 · Cited by 74
HIV increases the release of dickkopf‐1 protein from human astrocytes by a Cx43 hemichannel‐dependent mechanism
Orellana, J. A., Sáez, J. C., Bennett, M. V. L., Berman, J. W., Morgello, S., & Eugenín, E. A. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12492 · Cited by 73
The role of integration and clonal expansion in HIV infection: live long and prosper
Anderson, E. M., & Maldarelli, F. M. (2018) · Retrovirology · doi:10.1186/s12977-018-0448-8 · Cited by 75
Extracellular vesicles and chronic inflammation during HIV infection
Pérez, P. S., Romaniuk, M. A., Duette, G., Zhao, Z., Huang, Y., Jaular, L. M., Witwer, K. W., Théry, C., & Ostrowski, M. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1687275 · Cited by 73
HIV-infection of the central nervous system: the tightrope walk of innate immunity
Speth, C., Dierich, M. P., & Sopper, S. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.06.018 · Cited by 72
A novel action of minocycline: Inhibition of human immunodeficiency virus type 1 infection in microglia
Si, Q., Cosenza, M., Kim, M.-O., Zhao, M., Brownlee, M., Goldstein, H., & Lee, S. C. (2004) · Journal of NeuroVirology · doi:10.1080/13550280490499533 · Cited by 71
Self-citation
NeuroAIDS: Contributions of the human immunodeficiency virus‐1 proteins tat and gp120 as well as CD40 to microglial activation
D'Aversa, T. G., Eugenin, E., & Berman, J. W. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20486 · Cited by 75
Distinction of Microglia and Macrophages in Glioblastoma: Close Relatives, Different Tasks?
Brandenburg, S., Blank, A., Bungert, A. D., & Vajkoczy, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010194 · Cited by 65
Signaling through JAK2‐STAT5 pathway is essential for IL‐3‐induced activation of microglia
Bright, J. J., Natarajan, C., Sriram, S., & Muthian, G. (2003) · Glia · doi:10.1002/glia.10316 · Cited by 67
Imaging Neuroinflammation? A Perspective from MR Spectroscopy
Zahr, N. M., Mayer, D., Torsten Rohlfing, B., Sullivan, E. V., & Pfefferbaum, A. (2014) · Brain Pathology · doi:10.1111/bpa.12197 · Cited by 66
Cytochrome c dysregulation induced by HIV infection of astrocytes results in bystander apoptosis of uninfected astrocytes by an IP 3 and calcium‐dependent mechanism
Eugenin, E. A., & Berman, J. W. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12443 · Cited by 65
Pathological modeling of TBEV infection reveals differential innate immune responses in human neurons and astrocytes that correlate with their susceptibility to infection
Fares, M., Cochet, M., Gonzalez, G., Montero‐Menei, C. N., Blanchet, O., Benchoua, A., Boissart, C., Lecollinet, S., Richardson, J. P., Haddad, N., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01756-x · Cited by 62
Neurologic disease in HIV‐infected children and the impact of combination antiretroviral therapy
Crowell, C. S., Malee, K., Yogev, R., & Muller, W. J. (2014) · Reviews in Medical Virology · doi:10.1002/rmv.1793 · Cited by 62
HIV infection of non-classical cells in the brain
Wahl, A. R., & Al‐Harthi, L. (2023) · Retrovirology · doi:10.1186/s12977-023-00616-9 · Cited by 63
Does drug abuse alter microglial phenotype and cell turnover in the context of advancing HIV infection?
Anthony, I., Ramage, S., Carnie, F. W., Peter Simmonds, K., & Bell, J. E. (2005) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2005.00648.x · Cited by 60
The role of oxidative stress in HIV-associated neurocognitive disorders
Buckley, S., Byrnes, S. J., Cochrane, C. R., Roche, M., Estes, J. D., Selemidis, S., Angelovich, T. A., & Churchill, M. J. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100235 · Cited by 61
The Cytokine IL-1β Activates IFN Response Factor 3 in Human Fetal Astrocytes in Culture
Rivieccio, M. A., John, G. R., Song, X., Suh, H.-S., Zhao, Y., Lee, S. C., & Brosnan, C. F. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3719 · Cited by 59
Self-citation
Human Immunodeficiency Virus Infection of the Brain: Pitfalls in Evaluating Infected/Affected Cell Populations
Bissel, S. J., & Wiley, C. A. (2004) · Brain Pathology · doi:10.1111/j.1750-3639.2004.tb00503.x · Cited by 59
Injury‐induced NF‐κB activation in the hippocampus: implications for neuronal survival
Kassed, C. A., Butler, T. L., Patton, G. W., Mesquita, D. D. D., Navidomskis, M. T., Mémet, S., Israël, A., & Pennypacker, K. R. (2004) · The FASEB Journal · doi:10.1096/fj.03-0773fje · Cited by 57
Microglia in normal appearing white matter of multiple sclerosis are alerted but immunosuppressed
Melief, J., Schuurman, K. G., van de Garde, M. D. B., Smolders, J., van Eijk, M., Hamann, J., & Huitinga, I. (2013) · Glia · doi:10.1002/glia.22562 · Cited by 56
Mechanisms of HIV Neuropathogenesis: Role of Cellular Communication Systems
Malik, S., & Eugenin, E. A. (2016) · Current HIV Research · doi:10.2174/1570162x14666160324124558 · Cited by 57
Interactions of HIV and Drugs of Abuse
Hauser, K. F., & Knapp, P. E. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801284-0.00009-9 · Cited by 58
The NRTIs Lamivudine, Stavudine and Zidovudine Have Reduced HIV-1 Inhibitory Activity in Astrocytes
Gray, L. R., Tachedjian, G., Ellett, A. M., Roche, M., Cheng, W., Guillemin, G. J., Brew, B. J., Turville, S. G., Wesselingh, S. L., Gorry, P. R., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062196 · Cited by 53
HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency
Llewellyn, G. N., Alvarez-Carbonell, D., Chateau, M., Karn, J., & Cannon, P. M. (2017) · Journal of NeuroVirology · doi:10.1007/s13365-017-0604-2 · Cited by 55
Vpr- and Nef-Dependent Induction of RANTES/CCL5 in Microglial Cells
Si, Q., Kim, M.-O., Zhao, M., Landau, N. R., Goldstein, H., & Lee, S. C. (2002) · Virology · doi:10.1006/viro.2002.1613 · Cited by 52
Self-citation
Chemokines and Their Receptors in Central Nervous System Disease
Biber, K. P. H., de Jong, E., van Weering, H. R. J., & Boddeke, H. W. G. M. (2006) · Current Drug Targets · doi:10.2174/138945006775270196 · Cited by 52
Infection of Human Immunodeficiency Virus and Intracellular Viral Tat Protein Exert a Pro-survival Effect in a Human Microglial Cell Line
Chugh, P., Fan, S., Planelles, V., Maggirwar, S. B., Dewhurst, S., & Kim, B. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.11.011 · Cited by 51
Development and characterization of a human microglia cell model of HIV-1 infection
Rawat, P., & Spector, S. A. (2016) · Journal of NeuroVirology · doi:10.1007/s13365-016-0472-1 · Cited by 50
Cannabinoid receptor expression in HIV encephalitis and HIV‐associated neuropathologic comorbidities
Cosenza-Nashat, M. A., Bauman, A., Zhao, M. L., Morgello, S., Suh, H. ‐., & Lee, S. C. (2011) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2011.01177.x · Cited by 48
Self-citation
HIV-1 transcriptional regulation in the central nervous system and implications for HIV cure research
Churchill, M. J., Cowley, D., Wesselingh, S. L., Gorry, P. R., & Gray, L. R. (2014) · Journal of NeuroVirology · doi:10.1007/s13365-014-0271-5 · Cited by 48
Role of Connexin/Pannexin containing channels in infectious diseases
Eugenín, E. A. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.01.030 · Cited by 48
Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissue
Gonzalez-Perez, M. P., O’Connell, O., Lin, R., Sullivan, W. M., Bell, J. E., Peter Simmonds, K., & Clapham, P. R. (2012) · Retrovirology · doi:10.1186/1742-4690-9-20 · Cited by 48
Function of Connexins in the Interaction between Glial and Vascular Cells in the Central Nervous System and Related Neurological Diseases
Zhao, Y., Xin, Y., He, Z., & Hu, W. (2018) · Neural Plasticity · doi:10.1155/2018/6323901 · Cited by 49
A central role for glial CCR5 in directing the neuropathological interactions of HIV-1 Tat and opiates
Kim, S., Hahn, Y. K., Podhaizer, E. M., McLane, V. D., Zou, S., Hauser, K. F., & Knapp, P. E. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1320-4 · Cited by 48
Proliferation of Perivascular Macrophages Contributes to the Development of Encephalitic Lesions in HIV-Infected Humans and in SIV-Infected Macaques
Filipowicz, A. R., McGary, C. M., Holder, G. E., Lindgren, A. A., Johnson, E. M., Sugimoto, C., Kuroda, M. J., & Kim, W. (2016) · Scientific Reports · doi:10.1038/srep32900 · Cited by 45
HIV Alters Gap Junction-Mediated Intercellular Communication in Human Brain Pericytes
Cho, H. J., Kuo, A. M.-S., Bertrand, L., & Toborek, M. J. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00410 · Cited by 46
Variation of Macrophage Tropism among HIV-1 R5 Envelopes in Brain and Other Tissues
Peters, P. J., Duenas-Decamp, M. J., Sullivan, W. M., & Clapham, P. R. (2006) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-006-9042-2 · Cited by 45
Reduced cerebral blood flow and N-acetyl aspartate in a murine model of cerebral malaria
Kennan, R. P., Machado, F. S., Lee, S. C., Desruisseaux, M. S., Wittner, M., Tsuji, M., & Tanowitz, H. B. (2005) · Parasitology Research · doi:10.1007/s00436-005-1349-z · Cited by 44
Self-citation
Satellite glial cells in human trigeminal ganglia have a broad expression of functional Toll‐like receptors
Mitterreiter, J. G., Ouwendijk, W. J. D., van Velzen, M., van Nierop, G. P., Osterhaus, A. D. M. E., & Verjans, G. M. G. M. (2017) · European Journal of Immunology · doi:10.1002/eji.201746989 · Cited by 44
Thinking about HIV: the intersection of virus, neuroinflammation and cognitive dysfunction
Grovit‐Ferbas, K., & Harris‐White, M. E. (2010) · Immunologic Research · doi:10.1007/s12026-010-8166-x · Cited by 42
CD45 Isoform Expression in Microglia and Inflammatory Cells in HIV‐1 Encephalitis
Cosenza‐Nashat, M. A., Kim, M., Zhao, M., Suh, H., & Lee, S. C. (2006) · Brain Pathology · doi:10.1111/j.1750-3639.2006.00027.x · Cited by 43
Self-citation
Alarmins and central nervous system inflammation in HIV ‐associated neurological disorders
Gougeon, M. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12570 · Cited by 41
Silencing the Cytoskeleton Protein Iba1 (Ionized Calcium Binding Adapter Protein 1) Interferes with BV2 Microglia Functioning
Gheorghe, R., Deftu, A., Filippi, A., Grosu, A. V., Bica-Popi, M., Chiritoiu‐Butnaru, M., Chirițoiu, G. N., Munteanu, C. V. A., Silvestro, L., & Ristoiu, V. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00790-w · Cited by 41
Anti-Viral and Anti-Inflammatory Mechanisms of the Innate Immune Transcription Factor Interferon Regulatory Factor 3: Relevance to Human CNS Diseases
Tarassishin, L., Bauman, A., Suh, H.-S., & Lee, S. C. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9360-5 · Cited by 40
Self-citation
Macrophages in Progressive Human Immunodeficiency Virus/Simian Immunodeficiency Virus Infections
DiNapoli, S. R., Hirsch, V. M., & Brenchley, J. M. (2016) · Journal of Virology · doi:10.1128/jvi.00672-16 · Cited by 42
HIV‐1 expression protects macrophages and microglia from apoptotic death
Cosenza, M., Zhao, M. L., & Lee, S. C. (2004) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2004.00563.x · Cited by 40
Self-citation
HIV-1 envelope–receptor interactions required for macrophage infection and implications for current HIV-1 cure strategies
Gorry, P. R., Francella, N., Lewin, S. R., & Collman, R. G. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0713368 · Cited by 45

Authors: Cosenza;, M. A., Zhao;, M., Si;, Q., & Lee, S. C.
Affiliations: Albert Einstein College of Medicine (US)
Corresponding author: Lee, Sunhee C.
Venue: Brain Pathology
Publisher: Wiley
Published: 2002-10
Volume: 12
Issue: 4
Pages: 442-455
ISSN: 1015-6305 (ISSN-L)
1750-3639
DOI: 10.1111/j.1750-3639.2002.tb00461.x
PMC: PMC8095974
OpenAlex: W1990773400
Cited by: 238
References: 67
Citations by year: 2026: 5 · 2025: 3 · 2024: 9 · 2023: 9 · 2022: 10 · 2021: 17 · 2020: 10 · 2019: 13 · 2018: 13 · 2017: 12 · 2016: 8 · 2015: 4 · 2014: 18 · 2013: 18 · 2012: 5
FWCI: 3.44
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1282 d)
Locations: Brain Pathology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ai044641-04)
National Institute of Mental Health (R01MH055477, R24-MH-59724, R24MH059724, MH 55477)
National Institute of Allergy and Infectious Diseases (AI44641)
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
Keywords: microglia, HIV-1 encephalitis, CD14, CD45, perivascular macrophages, SIV encephalitis, HIV-1 p24 antigen, HIV-associated dementia, viral reservoir, brain macrophages
MeSH terms: Adult, Antigens, Surface, Brain, Cells, Cultured, Female, Fetus, Humans, Immunohistochemistry, Macrophages, Male, Middle Aged, Monocytes, Biomarkers, HIV-1, AIDS Dementia Complex, HIV Core Protein p24, Leukocyte Common Antigens, Microglia, Lipopolysaccharide Receptors, Cell Size

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Human Brain Parenchymal Microglia Express CD14 and CD45 and are Productively Infected by HIV‐1 in HIV‐1 Encephalitis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks