The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
A Human Gastric Simulator (HGS) to Study Food Digestion in Human Stomach
Abstract
Abstract: The objective of this study was to develop an in vitro stomach model, the Human Gastric Simulator (HGS), for studying gastric digestion of foods. The HGS is designed in such a way as to simulate the continuous peristaltic movement of stomach walls, with similar amplitude and frequency of contraction forces as reported in vivo . The HGS mainly consists of a latex vessel, simulating the stomach chamber, and a series of rollers secured on belts that are driven by motor and pulleys to create a continuous contraction of the latex wall. It also incorporates gastric secretion, emptying systems, and temperature control that enable accurate simulation of dynamic digestion process for detailed investigation of the changes in the physical chemical properties of ingested foods. The simulated gastric contraction force demonstrates a similar pattern as in vivo stomach forces. The precise control of gastric secretion and emptying and the adjustable mechanical forces in the HGS provide a useful tool to study transformation of food constituents under simulated physiological conditions. Practical Application: HGS could be used to study changes in the physical and chemical properties of gastric contents, and transformation of food constituents that occur during simulated digestion, and the influence of physiological conditions including acid and enzyme secretion and contraction forces on disintegration kinetics of foods and nutrient release.
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Citations
Cites
Disintegration of Solid Foods in Human Stomach
Kong, F., & Singh, R. P. (2008) · Journal of Food Science · doi:10.1111/j.1750-3841.2008.00766.x · Cited by 598
Self-citationDevelopment of an In Vitro Digestion Model for Estimating the Bioaccessibility of Soil Contaminants
Oomen, A. G., Rompelberg, C. J. M., Bruil, M. A., Dobbe, C. J. G., Pereboom, D. P. K. H., & Sips, A. J. A. M. (2003) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-002-1278-0 · Cited by 528
Comparison of Canine and Human Gastrointestinal Physiology
Dressman, J. B. (1986) · Pharmaceutical Research · doi:10.1023/a:1016353705970 · Cited by 339
Imaging and modelling of digestion in the stomach and the duodenum
Schulze, K. (2006) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00759.x · Cited by 256
Integrated Upper Gastrointestinal Response to Food Intake
Camilleri, M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.03.023 · Cited by 247
Assessment of antral grinding of a model solid meal with echo-planar imaging
Marciani, L., Gowland, P. A., Fillery-Travis, A., Manoj, P., Wright, J., Smith, A., Young, P., Moore, R., & Spiller, R. C. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.5.g844 · Cited by 210
Measurement of resistant starch: factors affecting the amount of starch escaping digestion in vitro
Muir, J., & O'Dea, K. (1992) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/56.1.123 · Cited by 195
Watanabe, S., & Dawes, C. (1988) · Archives of Oral Biology · doi:10.1016/0003-9969(88)90089-1 · Cited by 184
Chewing behavior and salivary secretion
Gavião, M. B. D., Engelen, L., & Van Der Bilt, A. (2004) · European Journal of Oral Sciences · doi:10.1111/j.0909-8836.2004.00105.x · Cited by 176
Kong, F., & Singh, R. P. (2008) · Journal of Food Science · doi:10.1111/j.1750-3841.2008.00745.x · Cited by 143
Self-citation
Cited by
A standardised static in vitro digestion method suitable for food – an international consensus
Minekus, M., Alminger, M., Alvito, P., Ballance, S., Bohn, T., Bourlieu, C., Carrière, F., Boutrou, R., Corredig, M., Dupont, D., et al. (2014) · Food Funct. · doi:10.1039/c3fo60702j · Cited by 5,824
Self-citationINFOGEST static in vitro simulation of gastrointestinal food digestion
Brodkorb, A., Egger, L., Alminger, M., Alvito, P., Assunção, R., Ballance, S., Bohn, T., Bourlieu-Lacanal, C., Boutrou, R., Carrière, F., et al. (2019) · Nature Protocols · doi:10.1038/s41596-018-0119-1 · Cited by 5,199
Self-citationIn vitro models for the prediction of in vivo performance of oral dosage forms
Kostewicz, E. S., Abrahamsson, B., Brewster, M., Brouwers, J., Butler, J., Carlert, S., Dickinson, P. A., Dressman, J., Holm, R., Klein, S., et al. (2014) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2013.08.024 · Cited by 373
Composition, Structure, and Digestive Dynamics of Milk From Different Species—A Review
Roy, D., Ye, A., Moughan, P. J., & Singh, H. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.577759 · Cited by 361
Can dynamic in vitro digestion systems mimic the physiological reality?
Dupont, D., Alric, M., Blanquet-Diot, S., Bornhorst, G., Cueva, C., Deglaire, A., Denis, S., Ferrua, M., Havenaar, R., Lelieveld, J., et al. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1421900 · Cited by 345
Metadata
- Authors
- Kong, F., & Singh, R. P.
- Venue
- Journal of Food Science
- Publisher
- Wiley
- Published
- 2010-11
- Volume
- 75
- Issue
- 9
- Pages
- E627-35
- ISSN
- 0022-1147 (ISSN-L)
- 1750-3841
- OpenAlex
- W1973092320
- Cited by
- 428
- References
- 19
- FWCI
- 11.86
- Type
- journal article
- Language
- en
- Open access
- closed
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