The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Derivatives of 5‐Aminolevulinic Acid for Photodynamic Therapy: Enzymatic Conversion into Protoporphyrin
Abstract
In recent years, 5‐aminolevulinic acid (ALA) has become a widespread agent for photodynamic therapy (PDT). In nucleated cells, ALA is converted into the endogenous photosensitizer protoporphyrin IX (PpIX). A major drawback of ALA is its low bioavailability. As a result, high doses of ALA must be administered in order to reach clinically relevant levels of PpIX. Moreover, only superficially located lesions can be treated as a result of the poor penetration of ALA into tissues. A possible solution for this problem may be provided by the prod rug concept. In the present study, prodrugs of ALA have been synthesized. These ALA prodrugs are shown to result in higher PpIX levels in cells than does ALA itself. Of a range of ester prodrugs of ALA, the ALA‐pentyl ester elicits the highest fluorescence. Further‐more, the enzymatic conversion of the derivatives into ALA and PpIX has been studied in lysed cells. Under these circumstances, the esters with the shorter alkyl chains induce the highest fluorescence. The alcohols that arise as side products from enzymatic conversion of the prodrugs are shown to have no influence on the experiments.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Photodynamic therapy with endogenous protoporphyrin
Kennedy, J. C., Pottier, R. H., & Pross, D. C. (1990) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/1011-1344(90)85083-9 · Cited by 1,509
5-Aminolevulinic Acid-Based Photodynamic Therapy: Principles and Experimental Research
Peng, Q., Berg, K., Moan, J., Kongshaug, M., & Nesland, J. M. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb08549.x · Cited by 615
Oral versus intravenous administration of 5-aminolaevulinic acid for photodynamic therapy
Loh, C., MacRobert, A., Bedwell, J., Regula, J., Krasner, N., & Bown, S. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.284 · Cited by 263
DISTRIBUTION OF 5‐AMINOLEVULINIC ACID‐INDUCED PORPHYRINS IN NODULOULCERATIVE BASAL CELL CARCINOMA
Peng, Q., Warloe, T., Moan, J., Heyerdahl, H., Steen, H. B., Nesland, J. M., & Giercksky, K. (1995) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1995.tb09154.x · Cited by 178
Hanania, J., & Malik, Z. (1992) · Cancer Letters · doi:10.1016/0304-3835(92)90156-p · Cited by 113
Cited by
5‐Aminolevulinic Acid Derivatives in Photomedicine: Characteristics, Application and Perspectives
Fotinos, N., Campo, M. A., Popowycz, F., Gurny, R., & Lange, N. (2006) · Photochemistry and Photobiology · doi:10.1562/2006-02-03-ir-794 · Cited by 238
Uehlinger, P., Zellweger, M., Wagnières, G., Juillerat-Jeanneret, L., van den Bergh, H., & Lange, N. (2000) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/s1011-1344(99)00159-1 · Cited by 221
Peng, Q., Soler, A. M., Warloe, T., Nesland, J. M., & Giercksky, K.-E. (2001) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/s1011-1344(01)00173-7 · Cited by 218
Casas, A., Perotti, C., Saccoliti, M., Sacca, P., Fukuda, H., & del C Batlle, A. M. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600144 · Cited by 52
Comparison of ALA- and ALA hexyl-ester-induced PpIX depth distribution in human skin carcinoma
Dögnitz, N., Salomon, D., Zellweger, M., Ballini, J.-P., Gabrecht, T., Lange, N., van den Bergh, H., & Wagnières, G. (2008) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/j.jphotobiol.2008.07.012 · Cited by 39
Metadata
- Authors
- Kloek, J., Akkermans, W., & van Henegouwen, G. M. J. B.
- Venue
- Photochemistry and Photobiology
- Publisher
- Wiley
- Published
- 1998-01
- Volume
- 67
- Issue
- 1
- Pages
- 150-154
- ISSN
- 0031-8655 (ISSN-L)
- 1751-1097
- OpenAlex
- W4230652189
- Cited by
- 177
- References
- 5
- FWCI
- 11.90
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Derivatives of 5‐Aminolevulinic Acid for Photodynamic Therapy: Enzymatic Conversion into Protoporphyrin. https://app.cochat.ai/papers/10.1111/j.1751-1097.1998.tb05178.x
- The paper
- Kloek, J., Akkermans, W., & van Henegouwen, G. M. J. B. (1998). Derivatives of 5‐Aminolevulinic Acid for Photodynamic Therapy: Enzymatic Conversion into Protoporphyrin. Photochemistry and Photobiology. https://doi.org/10.1111/j.1751-1097.1998.tb05178.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
