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Cited by 51Skin Protection and Agingmelanin and skin pigmentationNonmelanoma Skin Cancer Studies

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Protective Effect of Sanguinarine on Ultraviolet B‐mediated Damages in SKH‐1 Hairless Mouse Skin: Implications for Prevention of Skin Cancer

Ahsan, Haseeb, Reagan‐Shaw, Shannon, Eggert, David M., Tan, Thomas C., Afaq, Farrukh, Mukhtar, Hasan, Ahmad, Nihal·2007·Photochemistry and Photobiology
DOI 10.1111/j.1751-1097.2007.00156.x
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Abstract

Excessive exposure of solar ultraviolet (UV) radiation, particularly its UVB component (280–320 nm), to human skin is the major cause of skin cancers. UV exposure also leads to the development of precancerous conditions such as actinic keratosis and elicits a variety of other adverse effects such as sunburn, inflammation, hyperplasia, immunosuppression and skin aging. Therefore, there is a need to intensify our efforts towards the development of novel mechanism‐based approaches/agents for the protection of UVB‐mediated damages. Chemoprevention is being investigated as a potential approach for the management of UV damages including skin cancer. We have earlier shown that sanguinarine, a benzophenanthridine alkaloid, inhibits UVB exposure‐mediated damages in HaCaT keratinocytes. In this study, to determine the relevance of our in vitro findings to in vivo situations, we assessed the effects of sanguinarine on UVB‐mediated damages in SKH‐1 hairless mice. Our data demonstrated that a topical application of sanguinarine (5 μmol 0.3 mL−1 ethanol per mouse), either as a pretreatment (30 min prior to UVB) or posttreatment (5 min after UVB), resulted in a significant decrease in UVB‐mediated increases in skin edema, skin hyperplasia and infiltration of leukocytes. Further, sanguinarine treatments (pre and post) also resulted in a significant decrease in UVB mediated (1) generation of H 2 O 2 and (2) increases in the protein levels of markers of tumor promotion/proliferation viz. ornithine decarboxylase (ODC), proliferating cell nuclear antigen (PCNA) and Kiel antigen‐67. Based on this data, we suggest that sanguinarine could be developed as an agent for the management of conditions elicited by UV exposure including skin cancer. However, further detailed studies are needed to support this suggestion.

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Crossref · 10.1111/j.1751-1097.2007.00156.x

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  • Sanguinarine prevented UV-B-mediated elevations in ornithine decarboxylase, proliferating cell nuclear antigen and Kiel antigen-67.

    “Further, they also observed that sanguinarine prevented UV-B-mediated elevations in ornithine decarboxylase, proliferating cell nuclear antigen and Kiel antigen-67, all of which are indicators of cellular proliferation (Ahsan et al. 2007;Dinkova-Kostova 2008).”

    From Skin protection from solar ultraviolet radiation using natural compounds: a review (2024) · cites this paper as Ahsan et al. 2007

  • In vivo findings on SKH-1 hairless mice reported that pretreatment with sanguinarine significantly decreased UV-B-mediated skin edema, skin hyperplasia and infiltration of leukocytes.

    “Moreover, in vivo findings on SKH-1 hairless mice reported that pretreatment with sanguinarine significantly decreased the UV-B-mediated skin edema, skin hyperplasia and infiltration of leukocytes.”

    From Skin protection from solar ultraviolet radiation using natural compounds: a review (2024) · cites this paper as Ahsan et al. 2007

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Metadata

Authors
Ahsan, H., Reagan‐Shaw, S., Eggert, D. M., Tan, T. C., Afaq, F., Mukhtar, H., & Ahmad, N.
Affiliations
University of Wisconsin–Madison (US)
Corresponding author
Ahmad, Nihal
ORCID
Venue
Photochemistry and Photobiology
Publisher
Wiley
Published
2007-07
Volume
83
Issue
4
Pages
986-993
ISSN
  • 0031-8655 (ISSN-L)
  • 1751-1097
DOI
10.1111/j.1751-1097.2007.00156.x
OpenAlex
W1584296549
Cited by
51
References
1
Citations by year
2024: 3 · 2023: 2 · 2022: 2 · 2021: 14 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 6 · 2016: 2 · 2015: 2 · 2013: 2 · 2012: 3
FWCI
2.19
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Photochemistry and Photobiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r03ca099076-02)
  • National Cancer Institute (CA099076, CA114060, R01CA114060)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
  • Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
Keywords
sanguinarine, UV-B radiation, skin cancer chemoprevention, topical application, skin hyperplasia, skin edema, leukocyte infiltration, hydrogen peroxide production, ornithine decarboxylase, proliferating cell nuclear antigen, Ki-67, UV-induced skin damage
MeSH terms
Alkaloids, Animals, Female, Isoquinolines, Mice, Hairless, Skin Neoplasms, Ultraviolet Rays, Mice, Benzophenanthridines

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