Cited by 230Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionEicosanoids and Hypertension Pharmacology

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Vascular System: Role of Nitric Oxide in Cardiovascular Diseases

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Bian, Ka, Doursout, Marie‐Françoise, Murad, Ferid·2008·The Journal of Clinical Hypertension

DOI 10.1111/j.1751-7176.2008.06632.xPMC PMC8109995

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Abstract

In contrast with the short research history of the enzymatic synthesis of nitric oxide (NO), the introduction of nitrate-containing compounds for medicinal purposes marked its 150th anniversary in 1997. Glyceryl trinitrate (nitroglycerin) is the first compound of this category. On October 12, 1998, the Nobel Assembly awarded the Nobel Prize in Medicine or Physiology to scientists Robert Furchgott, Louis Ignarro, and Ferid Murad for their discoveries concerning NO as a signaling molecule in the cardiovascular system. NO-mediated signaling is a recognized component in various physiologic processes (eg, smooth muscle relaxation, inhibition of platelet and leukocyte aggregation, attenuation of vascular smooth muscle cell proliferation, neurotransmission, and immune defense), to name only a few. NO has also been implicated in the pathology of many inflammatory diseases, including arthritis, myocarditis, colitis, and nephritis and a large number of pathologic conditions such as amyotrophic lateral sclerosis, cancer, diabetes, and neurodegenerative diseases. Some of these processes (eg, smooth muscle relaxation, platelet aggregation, and neurotransmission) require only a brief production of NO at low nanomolar concentrations and are dependent on the recruitment of cyclic guanosine monophosphate (cGMP)-dependent signaling. Other processes are associated with direct interaction of NO or reactive nitrogen species derived from it with target proteins and requires a more sustained production of NO at higher concentrations but do not involve the cGMP pathway.

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Authors: Bian, K., Doursout, M., & Murad, F.
Affiliations: The University of Texas Health Science Center at Houston (US)
Corresponding author: Murad, Ferid
ORCID: Bian, Ka
Doursout, Marie‐Françoise
Venue: The Journal of Clinical Hypertension
Publisher: Wiley
Published: 2008-04
Volume: 10
Issue: 4
Pages: 304-310
ISSN: 1524-6175 (ISSN-L)
1751-7176
DOI: 10.1111/j.1751-7176.2008.06632.x
PMC: PMC8109995
OpenAlex: W2004742560
Semantic Scholar: 3f0ea8307ce77731d0e60b1fcc78d664629064bb
Cited by: 229
References: 41
Citations by year: 2026: 8 · 2025: 5 · 2024: 10 · 2023: 10 · 2022: 8 · 2021: 13 · 2020: 9 · 2019: 6 · 2018: 11 · 2017: 12 · 2016: 13 · 2015: 20 · 2014: 16 · 2013: 14 · 2012: 19
FWCI: 1.98
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 9 d)
Locations: Journal of Clinical Hypertension (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM061731, R01GM061731)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords: nitric oxide, cardiovascular disease, nitric oxide signaling, nitroglycerin, reactive nitrogen species, smooth muscle relaxation, platelet aggregation, vascular smooth muscle cell proliferation, inflammation
MeSH terms: Cardiovascular Agents, Cardiovascular Diseases, Cardiovascular System, Endothelium, Humans, Hypertension, Nitric Oxide, Signal Transduction, Reactive Oxygen Species, Reactive Nitrogen Species, Atherosclerosis

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Vascular System: Role of Nitric Oxide in Cardiovascular Diseases

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