Physical Exercise With Weight Reduction Lowers Blood Pressure and Improves Abnormal Left Ventricular Relaxation in Pharmacologically Treated Hypertensive Patients
Open accessAbstract
In spite of appropriate pharmacologic therapy, many hypertensive patients develop an abnormal left ventricular relaxation with preserved systolic function. This cardiac dysfunction increases the risk of cardiovascular complications. The authors assessed the therapeutic effects of an intervention with exercise training and weight reduction in patients with pharmacologically well‐treated hypertension who had abnormal left ventricular relaxation with normal systolic function. Eighty‐eight (44%) of 202 medically treated hypertensive patients had abnormal ventricular relaxation with normal ejection fraction. These patients were randomized to either a 6‐month intervention program (cycle ergometer training twice a day for 5 days a week and a hypocaloric diet) or a control program (unchanged pharmacologic therapy without exercise and diet. Body weight, blood pressure, New York Heart Association class, glomerular filtration rate, and exercise capacity and workload were measured. Cardiac function was assessed by measuring N‐terminal pro‐B‐type natriuretic peptide values, the electrocardiographic QT dispersion interval, and echocardiography (left atrial size, Doppler‐derived E/A ratio, and mitral deceleration time). Physical exercise with weight reduction reduced blood pressure, decreased cardiovascular risks, and improved abnormal left ventricular relaxation. Measuring left atrial size is the best method for assessing changes in left ventricular relaxation with preserved systolic function. J Clin Hypertens (Greenwich). 2011;13:23–29. ©2010 Wiley Periodicals, Inc.
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Physical fitness and activity status, along with genetic makeup, influence how well drugs work.
“The efficacy of drugs is affected by physical fitness/activity status (104, 328) in addition to genetic disposition.”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [104]
For patients with preserved ejection fraction and abnormal left ventricular relaxation, adding exercise and weight loss to drug therapy improved relaxation dysfunction that drug alone did not.
“in patients with abnormal left ventricular (LV) relaxation and preserved LV ejection fraction, exercise and weight loss plus drug reduced the LV relaxation dysfunction that was not reduced by the drug alone (104).”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [104]
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- Authors
- Cocco, G., & Pandolfi, S.
- ORCID
- Cocco, Giuseppe
- Venue
- The Journal of Clinical Hypertension
- Publisher
- Wiley
- Published
- 2010-10-06
- Volume
- 13
- Issue
- 1
- Pages
- 23-29
- ISSN
- 1524-6175 (ISSN-L)
- 1751-7176
- PMC
- PMC8673266
- OpenAlex
- W2092082959
- Cited by
- 32
- References
- 35
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 4 · 2012: 4
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Hypertension (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- hypertension, exercise training, weight loss, hypocaloric diet, left ventricular relaxation, diastolic dysfunction, preserved ejection fraction, blood pressure reduction, natriuretic peptides, QT dispersion, left atrial size, exercise capacity, cardiovascular risk
- MeSH terms
- Antihypertensive Agents, Blood Pressure, Body Weight, Diet, Reducing, Electrocardiography, Exercise Therapy, Female, Glomerular Filtration Rate, Humans, Hypertension, Male, Middle Aged, Weight Loss, Exercise, Ventricular Function, Left, Exercise Tolerance, Natriuretic Peptide, Brain
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