The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes
Open accessAbstract
Objectives: Chronic subacute inflammation is implicated in the pathogenesis of insulin resistance and type 2 diabetes. Salicylates were shown years ago to lower glucose and more recently to inhibit NF‐κB activity. Salsalate, a prodrug form of salicylate, has seen extensive clinical use and has a favorable safety profile. We studied the efficacy of salsalate in reducing glycemia and insulin resistance and potential mechanisms of action to validate NF‐κB as a potential pharmacologic target in diabetes. Methods and Results: In open label studies, both high (4.5 g/d) and standard (3.0 g/d) doses of salsalate reduced fasting and postchallenge glucose levels after 2 weeks of treatment. Salsalate increased glucose utilization during euglycemic hyperinsulinemic clamps, by approximately 50% and 15% at the high and standard doses, respectively, and insulin clearance was decreased. Dose‐limiting tinnitus occurred only at the higher dose. In a third, double‐masked, placebo‐controlled trial, 1 month of salsalate at maximum tolerable dose (no tinnitus) improved fasting and postchallenge glucose levels. Circulating free fatty acids were reduced and adiponectin increased in all treated subjects. Conclusions: These data demonstrate that salsalate improves in vivo glucose and lipid homeostasis, and support targeting of inflammation and NF‐κB as a therapeutic approach in type 2 diabetes.
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Cites
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Self-citationA central role for JNK in obesity and insulin resistance
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Metadata
- Authors
- Goldfine, A. B., Silver, R., Aldhahi, W., Cai, D., Tatro, E., Lee, J., & Shoelson, S. E.
- Venue
- Clinical and Translational Science
- Publisher
- Wiley
- Published
- 2008-05
- Volume
- 1
- Issue
- 1
- Pages
- 36-43
- ISSN
- 1752-8054 (ISSN-L)
- 1752-8062
- OpenAlex
- W2102177965
- Cited by
- 294
- References
- 51
- FWCI
- 11.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Goldfine, A. B., Silver, R., Aldhahi, W., Cai, D., Tatro, E., Lee, J., & Shoelson, S. E. (2008). Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes. Clinical and Translational Science. https://doi.org/10.1111/j.1752-8062.2008.00026.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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