The DOI matches its Crossref record; 90 of the 91 references it cites were found in a registry or an index.
The Epidemiology of Central Fat Distribution in Relation to Disease
Abstract
The effect of fat distribution on disease risk is a subject of great interest. Central fat has been measured anthropometrically, by computed tomography, and by magnetic resonance imaging. Both cross-sectional and longitudinal studies have related central fat to type 2 diabetes mellitus and cardiovascular disease, independent of body mass index. The mechanism may relate to increased lipolysis causing the liver to increase glucose and very low density lipoprotein output, while muscle uses less. This leads to a rise in blood glucose and triglycerides, a drop in HDL cholesterol, and an increase in small, dense LDL particles. There is also an increase in blood pressure and inflammatory markers. Certain populations put on excess fat more centrally than others. These include Asian populations. It is likely that with better differentiation of abdominal fat into visceral and subcutaneous depots, clearer data will accrue on their impact on disease risk.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Increased adiposity in women produces a relatively benign form of obesity, whereas in males it is associated with higher risk for hypertension, insulin resistance, diabetes, dyslipidemia, and heart disease [51].”
From Developmental programming of offspring adipose tissue biology and obesity risk (2021) · cites this paper as [51]
Citations
Cites
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850
Chronic Subclinical Inflammation as Part of the Insulin Resistance Syndrome
Festa, A., D’Agostino, R., Howard, G., Mykkänen, L., Tracy, R. P., & Haffner, S. M. (2000) · Circulation · doi:10.1161/01.cir.102.1.42 · Cited by 2,366
Larsson, B., Svärdsudd, K., Welin, L., Wilhelmsen, L., Björntorp, P. A., & Tibblin, G. (1984) · BMJ · doi:10.1136/bmj.288.6428.1401 · Cited by 1,931
Relation of Body Fat Distribution to Metabolic Complications of Obesity*
KISSEBAH, A. H., VYDELINGUM, N., MURRAY, R., EVANS, D. J., KALKHOFF, R. K., & ADAMS, P. W. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-2-254 · Cited by 1,909
Lapidus, L., Bengtsson, C., Larsson, B., Pennert, K. M., Rybo, E., & Sjöström, L. (1984) · BMJ · doi:10.1136/bmj.289.6454.1257 · Cited by 1,657
McKeigue, P. M., Shah, B., & Marmot, M. G. (1991) · The Lancet · doi:10.1016/0140-6736(91)91164-p · Cited by 1,618
Krotkiewski, M., Björntorp, P. A., Sjöström, L., & Smith, U. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111040 · Cited by 1,475
The Degree of Masculine Differentiation of Obesities
Vague, J. (1956) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/4.1.20 · Cited by 1,393
Research works printed but not linked: 4
- Stokes, 1985, Metabolic Complications of Human Obesity, S49
- Ducimetiere, 1985, Relationship between adiposity measurements and the incidence of coronary heart disease in a middle-aged male population-the Paris Prospective Study I, Am J Clin Nutr., 4, S31
- Landin, 1989, Importance of obesity for the metabolic abnormalities associated with an abdominal fat distribution pattern, Metabolism., 33, S68
- Vague, 1985, Metabolic Complications of Human Obesities, S3
Cited by
Sorted by citations
Sex differences in human adipose tissues – the biology of pear shape
Karastergiou, K., Smith, S. R., Greenberg, A. S., & Fried, S. K. (2012) · Biology of Sex Differences · doi:10.1186/2042-6410-3-13 · Cited by 1,109
Randall, J. C., Winkler, T. W., Kutalik, Z., Berndt, S. I., Jackson, A. U., Monda, K. L., Kilpeläinen, T. O., Esko, T., Mägi, R., Li, S., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003500 · Cited by 424
Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver
Goossens, G. H., Jocken, J. W. E., & Blaak, E. E. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00431-8 · Cited by 363
Genetics of Leptin and Obesity: A HuGE Review
Paracchini, V., Pedotti, P., & Taioli, E. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi174 · Cited by 302
on behalf of the Feel4Diabetes-study Group, Kyrou, I., Tsigos, C., Mavrogianni, C., Cardon, G., Stappen, V. V., Latomme, J., Kivelä, J., Wikström, K., Tsochev, Κ., et al. (2020) · BMC Endocrine Disorders · doi:10.1186/s12902-019-0463-3 · Cited by 337
Metadata
- Authors
- Pi-Sunyer, F. X.
- Venue
- Nutrition Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-07
- Volume
- 62
- Issue
- 7 Pt 2
- Pages
- S120-S126
- ISSN
- 0029-6643 (ISSN-L)
- 1753-4887
- OpenAlex
- W2170830702
- Cited by
- 153
- References
- 91
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 8 · 2023: 4 · 2022: 7 · 2021: 9 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 10 · 2013: 9 · 2012: 6
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- central fat distribution, abdominal obesity, visceral fat, subcutaneous adipose tissue, type 2 diabetes, cardiovascular disease, lipolysis, hepatic glucose production, VLDL, HDL cholesterol, small dense LDL, triglycerides, blood pressure, inflammatory markers, Asian populations, disease risk
- MeSH terms
- Abdomen, Adipose Tissue, Body Composition, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Obesity, Risk Factors, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
