Mediterranean food pattern and the primary prevention of chronic disease: recent developments
Abstract
Recent evidence supports the cardioprotective role of a Mediterranean food pattern. The major findings of the Greek and EPIC-Elderly cohort, the SUN study, the Medi-RIVAGE and the PREDIMED trials are reviewed. Definitive answers will come from ongoing primary prevention trials that assess clinical events as outcomes.
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The efficacy of the Mediterranean diet results as an attenuation of inflammation and oxidative stress, and from the maintenance of a condition of eubiosis of the microbiota, involved in the general improvement of immune response in these populations.
“The efficacy of this diet results as an attenuation of inflammation and oxidative stress, and from the maintenance of a condition of eubiosis of the microbiota, involved in the general improvement of immune response in these populations (68, 83–86).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [84]
The reduced consumption of animal proteins, in particular red and cured meat, is also important.
“The reduced consumption of animal proteins, in particular red and cured meat, is also important.”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [84]
The high rate of long living people and the low incidence of cardiovascular disease in many Mediterranean countries suggest the importance of a diet rich in fruits, vegetables, whole grains, legumes, and olive oil.
“The high rate of long living people and the low incidence of cardiovascular disease in many Mediterranean countries suggest the importance of a diet rich in fruits, vegetables, whole grains, legumes, and olive oil (probably the main anti-aging food in this area).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [84]
Current dietary investigations have found unsaturated fatty acids such as oleic and linoleic acid and dietary nitrate to be concentrated in the traditional Mediterranean diet, a diet with beneficial effects on the development of CVD and its risk factors.
“Current dietary investigations have found these fatty acids and dietary nitrate to be concentrated in the traditional Mediterranean diet, a diet with beneficial effects on the development of CVD and its risk factors[362,375–377].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [376]
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Self-citation
- Authors
- Martinez-Gonzalez, M. A., Bes-Rastrollo, M., Serra-Majem, L., Lairon, D., Estruch, R., & Trichopoulou, A.
- Affiliations
- Inserm (FR)
- Hospital Clínic de Barcelona (ES)
- National and Kapodistrian University of Athens (GR)
- Venue
- Nutrition Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-05
- Volume
- 67
- Pages
- S111-S116
- ISSN
- 0029-6643 (ISSN-L)
- 1753-4887
- OpenAlex
- W2151919309
- Cited by
- 200
- References
- 42
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 11 · 2020: 11 · 2019: 19 · 2018: 19 · 2017: 6 · 2016: 12 · 2015: 15 · 2014: 11 · 2013: 16 · 2012: 15
- FWCI
- 14.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition Reviews (publishedVersion)
- PubMed (publishedVersion)
- Acceda (Universidad de Las Palmas de Gran Canaria) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- Mediterranean diet, primary prevention, chronic disease, cardioprotection, PREDIMED trial, dietary intervention, cardiovascular disease
- MeSH terms
- Cardiovascular Diseases, Chronic Disease, Humans, Patient Compliance, Public Health, Diet, Mediterranean
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