The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Vitamin D and the occurrence of depression: causal association or circumstantial evidence?
Open accessAbstract
While recent laboratory-based studies have substantially advanced our understanding of the action of vitamin D in the brain, much is still unknown concerning how vitamin D relates to mood. The few epidemiological studies of vitamin D and depression have produced inconsistent results and generally have had substantial methodological limitations. Recent findings from a randomized trial suggest that high doses of supplemental vitamin D may improve mild depressive symptoms, but important questions persist concerning how vitamin D may affect monoamine function and hypothalamic-pituitary-adrenal axis response to stress, whether vitamin D supplementation can improve mood in individuals with moderate-to-severe depression, and whether vitamin D sufficiency is protective against incident depression and recurrence. At this time, it is premature to conclude that vitamin D status is related to the occurrence of depression. Additional prospective studies of this relationship are essential.
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“favorable effects from zinc supplementation on depression-related symptoms have been demonstrated in previous clinical trials (13,51,52)”
From Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial (2020) · cites this paper as [51]
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“In Ranjbar et al, it was reported that serum levels of BDNF in depressed patients receiving zinc supplement did not increase (51).”
From Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial (2020) · cites this paper as [51]
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Citations
Cites
An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032
Drevets, W. C., Price, J. L., & Furey, M. L. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0189-x · Cited by 2,241
Belmaker, R. H., & Agam, G. (2008) · New England Journal of Medicine · doi:10.1056/nejmra073096 · Cited by 2,166
Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis
Holick, M. F. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.3.362 · Cited by 1,670
Distribution of the vitamin D receptor and 1α-hydroxylase in human brain
Eyles, D. W., Smith, S., Kinobe, R., Hewison, M., & McGrath, J. J. (2005) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2004.08.006 · Cited by 1,444
Vitamin D: a millenium perspective
Holick, M. F. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10338 · Cited by 1,319
The role of dopamine in the pathophysiology of depression
Dunlop, B. W., & Nemeroff, C. B. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.3.327 · Cited by 1,244
Norman, A. W. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.2.491s · Cited by 1,090
New clues about vitamin D functions in the nervous system
Garcion, E., Wion-Barbot, N., Montero-Menei, C. N., Berger, F., & Wion, D. (2002) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(01)00547-1 · Cited by 904
Ruhé, H. G., Mason, N. S., & Schene, A. H. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001949 · Cited by 861
Research works printed but not linked: 3
- 6. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th ed: DSM-IV. Washington, DC: Author; 1994.
- Zehnder, 2001, Extrarenal expression of 25-hydroxyvitamin D3-1alpha-hydroxylase, J Clin Endocrinol Metab, 86, 888
- 59. American College of Obstetricians and Gynecologists Practice Bulletin. Clinical management guidelines for obstetricians-gynecologists. Number 15, April 2000. Premenstrual syndrome. Obstet Gynecol. 2000;95:1-9.
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Items 201–241 of 241
Guessous, I., & Bochud, M. (2013) · Swiss Medical Weekly · doi:10.4414/smw.2013.13822 · Cited by 1
Vitamin D and Multiple Sclerosis : immunological and clinical outcome
Knippenberg, S. A. M. (2013) · Research Publications (Maastricht University) · doi:10.26481/dis.20130328sk · Cited by 1
Gong, J., He, L., Zou, Q., Zhao, Y., Zhang, B., Xia, R., Chen, B., Cao, M., Gong, W., Lin, L., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1435047/v1 · Cited by 1
Efectos económicos y psicológicos de la latitud
León, F. R. (2014) · Revista de Investigación en Psicología · doi:10.15381/rinvp.v15i2.3701
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Cintron-Rivera, A. R. (2015) · CommonKnowledge Research Repository (Pacific University Oregon)
Ami, N. D. (2011) · Library and Archives Canada (Government of Canada)
Pan, A. (2011) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.223
The role of micronutrients in maternal mood and child neurodevelopment
Leung, B. M. Y. (2013) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/28334
Vitamin D and depression: A case series
Nadkarni, P., & Odejayi, G. (2014) · SAGE Open Medical Case Reports · doi:10.1177/2050313x14561570
Toffanello, E. D. (2013) · Padua Research Archive (University of Padova)
and meta-analysis Vitamin D deficiency and depression in adults: systematic review
Anglin, R., Samaan, Z., Walter, S. D., & McDonald, S. D. (2013)
EFECTOS ECONÓMICOS Y PSICOLÓGICOS DE LA LATITUD ECONOMIC AND PSYCHOLOGICAL EFFECTS OF LATITUDE
de Psicología, F., & León, F. R. (2012)
Vitamin Deficiencies and Depression: Evidence-Based Research
Greenblatt, J. M., & Patel, P. (2015) · CRC Press eBooks · doi:10.1201/b19089-9
Causes and Treatment of Herpes simplex Virus Recurrences
Ludema, C. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/3azd-8n31
Evaluation of Association of Vitamin D Deficiency with Depression in Postmenopausal Women
Civelek, G. M. (2015) · Turkish Journal of Osteoporosis · doi:10.4274/tod.18189
Associations between Plasma 25-Hydroxyvitamin D, Hormonal Contraceptives, and Premenstrual Symptoms
Jarosz, A. C. (2017) · TSpace (University of Toronto)
Vitamin D and Disease Prevention in Women
Bassuk, S. S., & Manson, J. E. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-384978-6.00060-1
Hubungan antara konsumsi vitamin D dan gangguan depresi pada lanjut usia
Dwana, L., & Abikusno, N. (2018) · Jurnal Biomedika dan Kesehatan · doi:10.18051/jbiomedkes.2018.v1.179-184
Assessment of Vitamin D Role in Depression
SHAABAN R. HELAL, M. D. ;. O. A. M., & EL-RAHMAN, M. D. E. S. K. A. A. (2018) · The Medical Journal of Cairo University/The Medical Journal of Cairo University · doi:10.21608/mjcu.2018.57504
Sanyal, D., & Mukherjee, P. (2021) · Indian Journal Of Applied Research · doi:10.36106/ijar/3501935
Vitamin D levels in women of reproductive age group- where do we stand?
Kulshrestha, M. R., & Kulshrestha, R. (2018) · Indian Journal of Obstetrics and Gynecology Research · doi:10.18231/2394-2754.2018.0030
D VITAMINO IR DEPRESIJOS RYŠYS
Gudaitis, A., & Prielaidaitė, K. (2021) · Health Sciences · doi:10.35988/sm-hs.2021.157
Assessment of Vitamin D Levels and Depression Among Adults in the United States
Owens, T. J.-L. (2015) · ScholarWorks (Walden University)
(2017) · CRC Press eBooks · doi:10.1201/9781315268828-7
El rol de los suplementos vitamínicos en pacientes con depresión
Pisula, P., Pulimens, C., & Vietto, V. (2022) · Evidencia actualizacion en la práctica ambulatoria · doi:10.51987/evidencia.v25i2.7003
Dikmen, M. (2020) · DergiPark (Istanbul University)
KOCAMAZ, M., & Erdoğdu, M. (2022) · JOURNAL OF SOCIAL HUMANITIES AND ADMINISTRATIVE SCIENCES · doi:10.29228/joshas.64026
Withstanding winter with mushroom therapy
Gibb, B. C. (2023) · Nature Chemistry · doi:10.1038/s41557-022-01129-2
Akın, A., & Yilmaz, T. S. (2023) · Ankara City Hospital Medical Journal · doi:10.5505/achmedj.2023.28247
Gong, J., He, L., Zou, Q., Zhao, Y., Zhang, B., Xia, R., Chen, B., Cao, M., Gong, W., Lin, L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20295774
Associations between vitamin D and depression in institutionalized oldest old
Isaev, R. I., Vorobyeva, N. M., Mkhitaryan, E. A., Marakhovskaya, E. A., & Ткачева, О. Н. (2024) · Russian Journal of Geriatric Medicine · doi:10.37586/2686-8636-2-2024-77-84
Generalized Anxiety: Linking in Vitamin D
Angelopoulos, N., Angelopoulou, K., & Karras, S. Ν. (2024) · Springer eBooks · doi:10.1007/978-3-031-32035-4_91-1 · Cited by 3
Association of asthma and allergy history with premenstrual symptom severity in young adult women
Caruso, I., Lu, D., Zagarins, S., & Bertone‐Johnson, E. R. (2025) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2025.100871
Self-citationGeneralized Anxiety: Linking in Vitamin D
Angelopoulos, N., Angelopoulou, K., & Karras, S. Ν. (2025) · Springer eBooks · doi:10.1007/978-3-031-73368-0_91
Shrateh, O. N., Jawed, A., Shuja, M. H., Kumar, K. A., Rehan, S. T., Abdelrhman, S., Naasan, M., & Wahab, N. A. A. (2025) · European Journal of Obstetrics & Gynecology and Reproductive Biology X · doi:10.1016/j.eurox.2025.100432
Gong, J., He, L., Zou, Q., Zhao, Y., Zhang, B., Xia, R., Chen, B., Cao, M., Gong, W., Lin, L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20295756
Gong, J., He, L., Zou, Q., Zhao, Y., Zhang, B., Xia, R., Chen, B., Cao, M., Gong, W., Lin, L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20295768
Gong, J., He, L., Zou, Q., Zhao, Y., Zhang, B., Xia, R., Chen, B., Cao, M., Gong, W., Lin, L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20295771
Gong, J., He, L., Zou, Q., Zhao, Y., Zhang, B., Xia, R., Chen, B., Cao, M., Gong, W., Lin, L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20295759
Metadata
- Authors
- Bertone-Johnson, E. R.
- Venue
- Nutrition Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-08
- Volume
- 67
- Issue
- 8
- Pages
- 481-492
- ISSN
- 0029-6643 (ISSN-L)
- 1753-4887
- PMC
- PMC2950608
- OpenAlex
- W2164305641
- Cited by
- 240
- References
- 73
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 12 · 2022: 24 · 2021: 17 · 2020: 15 · 2019: 19 · 2018: 16 · 2017: 13 · 2016: 8 · 2015: 24 · 2014: 17 · 2013: 20 · 2012: 19
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nutrition Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- National Institute of Mental Health (K01MH076274, MH076274)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Keywords
- vitamin D, depression, vitamin D supplementation, mood, hypothalamic-pituitary-adrenal axis, depression recurrence, vitamin D sufficiency, causal relationship
- MeSH terms
- Adult, Aged, Animals, Brain, Depression, Female, Humans, Male, Middle Aged, Premenstrual Syndrome, Stress, Psychological, Vitamin D, Vitamin D Deficiency, Biogenic Monoamines, Randomized Controlled Trials as Topic, Seasonal Affective Disorder, Receptors, Calcitriol, Mice
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