The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Vitamin D and the occurrence of depression: causal association or circumstantial evidence?
Open accessAbstract
While recent laboratory-based studies have substantially advanced our understanding of the action of vitamin D in the brain, much is still unknown concerning how vitamin D relates to mood. The few epidemiological studies of vitamin D and depression have produced inconsistent results and generally have had substantial methodological limitations. Recent findings from a randomized trial suggest that high doses of supplemental vitamin D may improve mild depressive symptoms, but important questions persist concerning how vitamin D may affect monoamine function and hypothalamic-pituitary-adrenal axis response to stress, whether vitamin D supplementation can improve mood in individuals with moderate-to-severe depression, and whether vitamin D sufficiency is protective against incident depression and recurrence. At this time, it is premature to conclude that vitamin D status is related to the occurrence of depression. Additional prospective studies of this relationship are essential.
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“favorable effects from zinc supplementation on depression-related symptoms have been demonstrated in previous clinical trials (13,51,52)”
From Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial (2020) · cites this paper as [51]
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“In Ranjbar et al, it was reported that serum levels of BDNF in depressed patients receiving zinc supplement did not increase (51).”
From Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial (2020) · cites this paper as [51]
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Cites
An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032
Drevets, W. C., Price, J. L., & Furey, M. L. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0189-x · Cited by 2,241
Belmaker, R. H., & Agam, G. (2008) · New England Journal of Medicine · doi:10.1056/nejmra073096 · Cited by 2,166
Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis
Holick, M. F. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.3.362 · Cited by 1,670
Distribution of the vitamin D receptor and 1α-hydroxylase in human brain
Eyles, D. W., Smith, S., Kinobe, R., Hewison, M., & McGrath, J. J. (2005) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2004.08.006 · Cited by 1,444
Vitamin D: a millenium perspective
Holick, M. F. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10338 · Cited by 1,319
The role of dopamine in the pathophysiology of depression
Dunlop, B. W., & Nemeroff, C. B. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.3.327 · Cited by 1,244
Norman, A. W. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.2.491s · Cited by 1,090
New clues about vitamin D functions in the nervous system
Garcion, E., Wion-Barbot, N., Montero-Menei, C. N., Berger, F., & Wion, D. (2002) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(01)00547-1 · Cited by 904
Ruhé, H. G., Mason, N. S., & Schene, A. H. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001949 · Cited by 861
Research works printed but not linked: 3
- 6. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th ed: DSM-IV. Washington, DC: Author; 1994.
- Zehnder, 2001, Extrarenal expression of 25-hydroxyvitamin D3-1alpha-hydroxylase, J Clin Endocrinol Metab, 86, 888
- 59. American College of Obstetricians and Gynecologists Practice Bulletin. Clinical management guidelines for obstetricians-gynecologists. Number 15, April 2000. Premenstrual syndrome. Obstet Gynecol. 2000;95:1-9.
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Vitamin D deficiency and depression in adults: systematic review and meta-analysis
Anglin, R. E. S., Samaan, Z., Walter, S. D., & McDonald, S. D. (2013) · British Journal of Psychiatry · doi:10.1192/bjp.bp.111.106666 · Cited by 820
Depression as a disease of modernity: explanations for increasing prevalence
Hidaka, B. H. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.12.036 · Cited by 769
Eyles, D. W., Burne, T. H. J., & McGrath, J. J. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.07.001 · Cited by 726
Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses
Sarris, J., Murphy, J., Mischoulon, D., Papakostas, G. I., Fava, M., Berk, M., & Ng, C. H. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.15091228 · Cited by 436
Parker, G. B., Brotchie, H., & Graham, R. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.08.082 · Cited by 296
Metadata
- Authors
- Bertone-Johnson, E. R.
- Venue
- Nutrition Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-08
- Volume
- 67
- Issue
- 8
- Pages
- 481-492
- ISSN
- 0029-6643 (ISSN-L)
- 1753-4887
- PMC
- PMC2950608
- OpenAlex
- W2164305641
- Cited by
- 240
- References
- 73
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 12 · 2022: 24 · 2021: 17 · 2020: 15 · 2019: 19 · 2018: 16 · 2017: 13 · 2016: 8 · 2015: 24 · 2014: 17 · 2013: 20 · 2012: 19
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nutrition Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- National Institute of Mental Health (K01MH076274, MH076274)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Keywords
- vitamin D, depression, vitamin D supplementation, mood, hypothalamic-pituitary-adrenal axis, depression recurrence, vitamin D sufficiency, causal relationship
- MeSH terms
- Adult, Aged, Animals, Brain, Depression, Female, Humans, Male, Middle Aged, Premenstrual Syndrome, Stress, Psychological, Vitamin D, Vitamin D Deficiency, Biogenic Monoamines, Randomized Controlled Trials as Topic, Seasonal Affective Disorder, Receptors, Calcitriol, Mice
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