The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Cancer stem cells and human malignant melanoma
Open accessAbstract
Summary: Cancer stem cells (CSC) have been identified in hematological malignancies and several solid cancers. Similar to physiological stem cells, CSC are capable of self‐renewal and differentiation and have the potential for indefinite proliferation, a function through which they may cause tumor growth. Although conventional anti‐cancer treatments might eradicate most malignant cells in a tumor, they are potentially ineffective against chemoresistant CSC, which may ultimately be responsible for recurrence and progression. Human malignant melanoma is a highly aggressive and drug‐resistant cancer. Detection of tumor heterogeneity, undifferentiated molecular signatures, and increased tumorigenicity of melanoma subsets with embryonic‐like differentiation plasticity strongly suggest the presence and involvement of malignant melanoma stem cells (MMSC) in the initiation and propagation of this malignancy. Here, we review these findings in the context of functional properties ascribed to melanocyte stem cells and CSC in other cancers. We discuss the association of deregulated signaling pathways, genomic instability, and vasculogenic mimicry phenomena observed in melanoma subpopulations in light of the CSC concept. We propose that a subset of MMSC may be responsible for melanoma therapy‐resistance, tumor invasiveness, and neoplastic progression and that targeted abrogation of a MMSC compartment could therefore ultimately lead to stable remissions and perhaps cures of metastatic melanoma.
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Cites
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Cited by
Cancer stem cells versus phenotype‐switching in melanoma
Hoek, K. S., & Goding, C. R. (2010) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2010.00757.x · Cited by 506
Intratumor and Intertumor Heterogeneity in Melanoma
Grzywa, T. M., Paskal, W., & Włodarski, P. K. (2017) · Translational Oncology · doi:10.1016/j.tranon.2017.09.007 · Cited by 299
Modulation of T-Cell Activation by Malignant Melanoma Initiating Cells
Schatton, T., Schütte, U., Frank, N. Y., Zhan, Q., Hoerning, A., Robles, S. C., Zhou, J., Hodi, F. S., Spagnoli, G. C., Murphy, G. F., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-1592 · Cited by 287
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Diener, J., & Sommer, L. (2021) · Stem Cells Translational Medicine · doi:10.1002/sctm.20-0351 · Cited by 64
Metadata
- Authors
- Schatton, T., & Frank, M. H.
- Venue
- Pigment Cell & Melanoma Research
- Publisher
- Wiley
- Published
- 2008-02
- Volume
- 21
- Issue
- 1
- Pages
- 39-55
- ISSN
- 1755-1471 (ISSN-L)
- 1755-148X
- OpenAlex
- W2111804172
- Cited by
- 210
- References
- 20
- FWCI
- 10.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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