Cited by 53Skin Protection and Agingmelanin and skin pigmentationMelanoma and MAPK Pathways

Ultraviolet wavebands and melanoma initiation

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Bennett, Dorothy C.·2008·Pigment Cell & Melanoma Research

Abstract

Summary: In view of claims that ultraviolet radiation‐emitting sunbeds are safe, or safe when they emit only longer wavelengths, research findings are reviewed here on the effects of ultraviolet wavebands A and B (UVA, 315–400 nm and UVB, 290–315 nm) on mutagenesis and carcinogenesis in skin, with particular reference to melanocytes and melanoma. Both UVA and UVB radiation have been shown to induce mutations, as well as mutagenic photoproducts such as cyclobutane pyrimidine dimers, in human skin. UVB can induce melanoma in susceptible mice and in xenografted human skin engineered to express melanocyte growth factors. There is evidence for photosensitization of melanocytes by melanin, especially pheomelanin. UVA can induce melanoma in pigmented fish, and melanocytic hyperplasia in pigmented opossums, but has not generally been tested for melanoma induction in pigmented mammals or in human skin. There is no experimental basis for a claim that UVA is safe, and recreational exposure to this known mutagen should be discouraged.

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Crossref · 10.1111/j.1755-148x.2008.00500.x

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Authors
Bennett, D. C.
Affiliations
University of London (GB)
Corresponding author
Bennett, Dorothy C.
Venue
Pigment Cell & Melanoma Research
Publisher
Wiley
Published
2008-09-18
Volume
21
Issue
5
Pages
520-524
ISSN
  • 1755-1471 (ISSN-L)
  • 1755-148X
OpenAlex
W1552185058
Cited by
53
References
43
Citations by year
2024: 2 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 7 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 5
FWCI
8.19
Type
journal article
Language
en
Open access
Locations
  • Pigment Cell & Melanoma Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Wellcome Trust
  • Cancer Research UK
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
Keywords
ultraviolet radiation, UVA, UV-B radiation, melanoma initiation, sunbeds, cyclobutane pyrimidine dimers, melanocytes, pheomelanin, melanocytic hyperplasia, carcinogenesis
MeSH terms
Adolescent, Animals, Child, Humans, Melanoma, Skin, Skin Neoplasms, Skin Pigmentation, Ultraviolet Rays, Mice

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