The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Molecular mechanisms of retinal pigment epithelium damage and development of age‐related macular degeneration
Open accessAbstract
Abstract.: Age‐related macular degeneration (AMD) is attributed to a complex interaction of genetic and environmental factors. It is characterized by degeneration involving the retinal photoreceptors, retinal pigment epithelium (RPE) and Bruch’s membrane, as well as alterations in choroidal capillaries. AMD pathogenesis is strongly associated with chronic oxidative stress and inflammation that ultimately lead to protein damage, aggregation and degeneration of RPE. Specific degenerative findings for AMD are accumulation of intracellular lysosomal lipofuscin and extracellular drusens. In this review, we discuss thoroughly RPE‐derived mechanisms in AMD pathology.
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Cites
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Cited by
The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD
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Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration
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Risk factors and biomarkers of age-related macular degeneration
Lambert, N. G., ElShelmani, H., Singh, M. K., Mansergh, F. C., Wride, M. A., Padilla, M., Keegan, D., Hogg, R. E., & Ambati, B. K. (2016) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2016.04.003 · Cited by 351
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Self-citationTseng, W. A., Thein, T., Kinnunen, K., Lashkari, K., Gregory, M. S., D'Amore, P. A., & Ksander, B. R. (2013) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.12-10655 · Cited by 290
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Metadata
- Authors
- Kinnunen, K., Petrovski, G., Moe, M. C., Berta, A., & Kaarniranta, K.
- Venue
- Acta Ophthalmologica
- Publisher
- Wiley
- Published
- 2011-11-23
- Volume
- 90
- Issue
- 4
- Pages
- 299-309
- ISSN
- 0001-639X (ISSN-L)
- 1755-375X
- 1755-3768
- OpenAlex
- W1970528463
- Cited by
- 197
- References
- 33
- FWCI
- 13.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kinnunen, K., Petrovski, G., Moe, M. C., Berta, A., & Kaarniranta, K. (2012). Molecular mechanisms of retinal pigment epithelium damage and development of age‐related macular degeneration. Acta Ophthalmologica. https://doi.org/10.1111/j.1755-3768.2011.02179.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
