Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration
Open accessAbstract
Age-related macular degeneration (AMD) is a devastating neurodegenerative disease and a major cause of blindness in the developed world. Owing to its complexity and the lack of an adequate human model that recapitulates key aspects of the disease, the molecular mechanisms of AMD pathogenesis remain poorly understood. Here we show that cultured human retinal pigment epithelium (RPE) from AMD donors (AMD RPE) are functionally impaired and exhibit distinct phenotypes compared with RPE cultured from normal donors (normal RPE). Accumulation of lipid droplets and glycogen granules, disintegration of mitochondria, and an increase in autophagosomes were observed in AMD RPE cultures. Compared with normal RPE, AMD RPE exhibit increased susceptibility to oxidative stress, produce higher levels of reactive oxygen species (ROS) under stress conditions, and showed reduced mitochondrial activity. Measurement of the ratio of LC3-II/ LC3-I, revealed impaired autophagy in AMD RPE as compared with normal RPE. Autophagic flux was also reduced in AMD RPE as compared with normal RPE, as shown by inability of AMD RPE to downregulate p62 levels during starvation. Impaired autophagic pathways were further shown by analyzing late autophagic vesicles; immunostaining with lysosome-associated membrane protein 1 (LAMP-1) antibody revealed enlarged and annular LAMP-1-positive organelles in AMD RPE as opposed to smaller discrete puncta observed in normal RPE. Our study provides insights into AMD cellular and molecular mechanisms, proposes dysfunctional autophagy as an underlying mechanism contributing to the pathophysiology of the disease, and opens up new avenues for development of novel treatment strategies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
RPE cultures established from AMD donors exhibited several features of disrupted autophagy, including decreased LC3B-II expression, swollen autolysosomes, and increased p62.
“RPE cultures established from AMD donors exhibited several features of disrupted autophagy, including decreased LC3B-II expression, swollen autolysosomes, and increased p62 (Golestaneh et al., 2017).”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Golestaneh et al., 2017
AMD donor RPE cultures also accumulated lipid droplets, glycogen granules, and fragmented mitochondria, indicating a global breakdown of cellular clearance pathways.
“AMD donor RPE cultures also accumulated lipid droplets, glycogen granules, and fragmented mitochondria, indicating a global breakdown of cellular clearance pathways.”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Golestaneh et al., 2017
Lysosomes in cultured human RPE from AMD donors were found to be enlarged and annular; whether this abnormal lysosome morphology is associated with decreased hydrolytic function is not yet known.
“Lysosomes in cultured human RPE from AMD donors were found to be enlarged and annular; however, whether this abnormal lysosome morphology is associated with decreased hydrolytic function is not yet known (Golestaneh et al., 2017).”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Golestaneh et al., 2017
Lipid oxidation is a critical factor in the development of AMD.
“Lipid oxidation is a critical factor in the development of AMD (Balaratnasingam et al., 2017; Golestaneh et al., 2017; Handa et al., 2017; Xu et al., 2017).”
From Microtubule-associated protein 1 light chain 3B, (LC3B) is necessary to maintain lipid-mediated homeostasis in the retinal pigment epithelium (2018) · cites this paper as Golestaneh et al., 2017
LC3II/LC3I ratios were lower in RPE from AMD patients, with decreased autophagic flux and mitochondrial accumulation.
“LC3II/LC3I ratios were lower in RPE from AMD patients with decreased autophagic flux and mitochondrial accumulation (suggestive of altered mitophagy) (Golestaneh et al., 2017)”
From Microtubule-associated protein 1 light chain 3B, (LC3B) is necessary to maintain lipid-mediated homeostasis in the retinal pigment epithelium (2018) · cites this paper as Golestaneh et al., 2017
Dysregulated or dysfunctional autophagy contributes to AMD.
“leading these and other investigators doing in vitro work to conclude that dysregulated or dysfunctional autophagy contributes to AMD.”
From Microtubule-associated protein 1 light chain 3B, (LC3B) is necessary to maintain lipid-mediated homeostasis in the retinal pigment epithelium (2018) · cites this paper as Golestaneh et al., 2017
RPE cultures derived from human donor eyes of AMD patients exhibited increased intracellular lipid accumulation and oxidative stress.
“RPE cultures derived from human donor eyes (patients with AMD), exhibited increased intracellular lipid accumulation and oxidative stress.”
From Microtubule-associated protein 1 light chain 3B, (LC3B) is necessary to maintain lipid-mediated homeostasis in the retinal pigment epithelium (2018) · cites this paper as Golestaneh et al., 2017
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351 · see citing works
Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214 · see citing works
Cillà, S. D., Farruggio, S., Vujosevic, S., Raina, G., Filippini, D. A., Gatti, V., Clemente, N., Mary, D., Vezzola, D., Casini, G., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479441 · Cited by 5,154 · see citing works
Pankiv, S., Clausen, T. H., Lamark, T., Brech, A., Bruun, J.-A., Outzen, H., Øvervatn, A., Bjørkøy, G., & Johansen, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702824200 · Cited by 4,578 · see citing works
Autophagy regulates lipid metabolism
Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975 · see citing works
Mitochondrial Fission, Fusion, and Stress
Youle, R. J., & van der Bliek, A. M. (2012) · Science · doi:10.1126/science.1219855 · Cited by 3,674 · see citing works
Bjørkøy, G., Lamark, T., Brech, A., Outzen, H., Perander, M., Øvervatn, A., Stenmark, H., & Johansen, T. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507002 · Cited by 3,276 · see citing works
de Duve, C., & Wattiaux, R. (1966) · Annual Review of Physiology · doi:10.1146/annurev.ph.28.030166.002251 · Cited by 3,033 · cited 1× · see citing works
“non-essential or damaged cellular constituents to supply the cell with energy and to maintain homeostasis.(18,19) Recently,”
The Retinal Pigment Epithelium in Visual Function
Strauss, O. (2005) · Physiological Reviews · doi:10.1152/physrev.00021.2004 · Cited by 2,828 · see citing works
Physiological Roles of Mitochondrial Reactive Oxygen Species
Sena, L. A., & Chandel, N. S. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.09.025 · Cited by 2,632 · see citing works
How to Interpret LC3 Immunoblotting
Mizushima, N., & Yoshimori, T. (2007) · Autophagy · doi:10.4161/auto.4600 · Cited by 2,595 · cited 1× · see citing works
“after lipidation becomes LC3-II, is inserted into the inner and outer membranes of the AP and is eventually degraded.(34)”
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.
Komatsu, M., Waguri, S., Koike, M., Sou, Y.-S., Ueno, T., Hara, T., Mizushima, N., Iwata, J.-I., Ezaki, J., Murata, S., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.035 · Cited by 2,124 · see citing works
Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107 · see citing works
The Role of Oxidative Stress in the Pathogenesis of Age-Related Macular Degeneration
Beatty, S., Koh, H.-H., Phil, M., Henson, D., & Boulton, M. (2000) · Survey of Ophthalmology · doi:10.1016/s0039-6257(00)00140-5 · Cited by 2,051 · see citing works
Age-related macular degeneration
Lim, L. S., Mitchell, P., Seddon, J. M., Holz, F. G., & Wong, T. Y. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60282-7 · Cited by 1,764 · see citing works
Autophagy in cell death: an innocent convict?
Levine, B. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26390 · Cited by 1,671 · see citing works
Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases
Chen, H., & Chan, D. C. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp326 · Cited by 1,455 · see citing works
Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling.
Lee, J., Giordano, S., & Zhang, J. (2012) · Biochemical Journal · doi:10.1042/bj20111451 · Cited by 1,438 · see citing works
Autophagy maintains stemness by preventing senescence
García-Prat, L., Martínez-Vicente, M., Perdiguero, E., Ortet, L., Rodríguez-Ubreva, J., Rebollo, E., Ruiz-Bonilla, V., Gutarra, S., Ballestar, E., Serrano, A. L., et al. (2016) · Nature · doi:10.1038/nature16187 · Cited by 1,355 · see citing works
Drusen proteome analysis: an approach to the etiology of age-related macular degeneration
Crabb, J. W., Miyagi, M., Gu, X., Shadrach, K., West, K. A., Sakaguchi, H., Kamei, M., Hasan, A., Yan, L., Rayborn, M. E., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222551899 · Cited by 1,208 · see citing works
Chapter 12 Monitoring Autophagic Degradation of p62/SQSTM1
Bjørkøy, G., Lamark, T., Pankiv, S., Øvervatn, A., Brech, A., & Johansen, T. (2009) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)03612-4 · Cited by 1,145 · see citing works
Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy
Tanida, I., Minematsu-Ikeguchi, N., Ueno, T., & Kominami, E. (2005) · Autophagy · doi:10.4161/auto.1.2.1697 · Cited by 1,108 · cited 1× · see citing works
“Lysosomal inhibitors E64d and Pepstatin A were added in the last 2 h of starvation at a concentration of 10 μg/ml and the cells were lysed and analyzed with immunoblot for LC3 and p62 based on the established protocol.(35)”
MethodAge-Related Macular Degeneration and Blindness due to Neovascular Maculopathy
Ferris, F. L., Fine, S., & Hyman, L. (1984) · Archives of Ophthalmology · doi:10.1001/archopht.1984.01040031330019 · Cited by 1,097 · see citing works
Yoshida, H. (2007) · The FEBS Journal · doi:10.1111/j.1742-4658.2007.05639.x · Cited by 1,086 · see citing works
Mechanisms of Age-Related Macular Degeneration
Ambati, J., & Fowler, B. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.018 · Cited by 1,029 · see citing works
Morita, M., Gravel, S.-P., Chénard, V., Sikström, K., Zheng, L., Alain, T., Gandin, V., Avizonis, D., Arguello, M., Zakaria, C., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.10.001 · Cited by 842 · see citing works
Endoplasmic reticulum stress in disease pathogenesis.
Lin, J. H., Walter, P., & Yen, T. S. B. (2008) · Annual Review of Pathology · doi:10.1146/annurev.pathmechdis.3.121806.151434 · Cited by 830 · see citing works
Studies on the mechanisms of autophagy: formation of the autophagic vacuole.
Dunn, W. A. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.6.1923 · Cited by 787 · see citing works
Nazio, F., Strappazzon, F., Antonioli, M., Bielli, P., Cianfanelli, V., Bordi, M., Gretzmeier, C., Dengjel, J., Piacentini, M., Fimia, G. M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2708 · Cited by 783 · see citing works
Age‐related macular degeneration—emerging pathogenetic and therapeutic concepts
Gehrs, K. M., Anderson, D. H., Johnson, L. V., & Hageman, G. S. (2006) · Annals of Medicine · doi:10.1080/07853890600946724 · Cited by 633 · see citing works
Oxidative damage and protection of the RPE
Cai, J., Nelson, K. C., Wu, M., Sternberg, P., & Jones, D. P. (2000) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(99)00009-9 · Cited by 628 · see citing works
Age-related macular degeneration (AMD): pathogenesis and therapy.
Nowak, J. Z. (2006) · PubMed · Cited by 607 · see citing works
Prevalence of Age-Related Macular Degeneration in the US Population
Klein, R. (2011) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2010.318 · Cited by 512 · see citing works
p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway
Durán, Á., Amanchy, R., Linares, J. F., Joshi, J. P., Abu‐Baker, S., Porollo, A., Hansen, M., Moscat, J., & Díaz-Meco, M. T. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.038 · Cited by 502 · see citing works
The role of the retinal pigment epithelium: Topographical variation and ageing changes
Boulton, M., & Dayhaw‐Barker, P. (2001) · Eye · doi:10.1038/eye.2001.141 · Cited by 489 · see citing works
Mitter, S. K., Song, C., Qi, X., Mao, H., Rao, H., Akin, D., Lewin, A., Grant, M., Dunn, W., Ding, J., et al. (2014) · Autophagy · doi:10.4161/auto.36184 · Cited by 449 · see citing works
Maminishkis, A., Chen, S., Jalickee, S., Banzon, T., Shi, G., Wang, F. E., Ehalt, T., Hammer, J. A., & Miller, S. S. (2006) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.05-1622 · Cited by 401 · see citing works
Direct control of mitochondrial function by mTOR
Ramanathan, A., & Schreiber, S. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912074106 · Cited by 365 · see citing works
Wang, A. L., Lukas, T. J., Yuan, M., Du, N. Y., Tso, M. O. M., & Neufeld, A. H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004160 · Cited by 357 · see citing works
Drusen in Age-Related Macular Degeneration
Abdelsalam, A., Del Priore, L., & Zarbin, M. A. (1999) · Survey of Ophthalmology · doi:10.1016/s0039-6257(99)00072-7 · Cited by 352 · see citing works
Endoplasmic Reticulum Stress: Its Role in Disease and Novel Prospects for Therapy
Schönthal, A. H. (2012) · Scientifica · doi:10.6064/2012/857516 · Cited by 350 · see citing works
Forecasting Age-Related Macular Degeneration Through the Year 2050
Rein, D. B. (2009) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2009.58 · Cited by 345 · see citing works
Kaarniranta, K., Sinha, D., Blasiak, J., Kauppinen, A., Veréb, Z., Salminen, A., Boulton, M. E., & Petrovski, G. (2013) · Autophagy · doi:10.4161/auto.24546 · Cited by 326 · see citing works
Proteolytic and lipolytic responses to starvation
Finn, P. F., & Dice, J. F. (2006) · Nutrition · doi:10.1016/j.nut.2006.04.008 · Cited by 321 · see citing works
Saari, J. C., Nawrot, M., Kennedy, B. N., Garwin, G. G., Hurley, J. B., Huang, J., Possin, D. E., & Crabb, J. W. (2001) · Neuron · doi:10.1016/s0896-6273(01)00248-3 · Cited by 250 · see citing works
Mitochondrial Dysfunction Indirectly Elevates ROS Production by the Endoplasmic Reticulum
Murphy, M. P. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.07.006 · Cited by 230 · see citing works
Autophagy in health and disease. 5. Mitophagy as a way of life
Gottlieb, R. A., & Carreira, R. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00097.2010 · Cited by 228 · see citing works
Zhang, Y., Qi, H., Taylor, R., Xu, W., Liu, L. F., & Jin, S. V. (2007) · Autophagy · doi:10.4161/auto.4127 · Cited by 211 · see citing works
Fundus Autofluorescence and Progression of Age-related Macular Degeneration
Schmitz-Valckenberg, S., Fleckenstein, M., Scholl, H. P. N., & Holz, F. G. (2009) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2008.10.004 · Cited by 203 · see citing works
Kinnunen, K., Petrovski, G., Moe, M. C., Berta, A., & Kaarniranta, K. (2011) · Acta Ophthalmologica · doi:10.1111/j.1755-3768.2011.02179.x · Cited by 197 · see citing works
Johnson, L. V., Forest, D. L., Banna, C. D., Radeke, C. M., Maloney, M. A., Hu, J. G., Spencer, C. N., Walker, A. M., Tsie, M. S., Bok, D., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109703108 · Cited by 196 · see citing works
Glycogen accumulation underlies neurodegeneration and autophagy impairment in Lafora disease
Durán, J., Gruart, A., Garcı́a-Rocha, M., Delgado-García, J. M., & Guinovart, J. J. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu024 · Cited by 181 · see citing works
Changes in Visual Acuity in a Population Over a 15-year Period: The Beaver Dam Eye Study
Klein, R., Klein, R., Lee, K. E., Cruickshanks, K. J., & Gangnon, R. E. (2006) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2006.06.015 · Cited by 172 · see citing works
Lin, H., Xu, H. C., Liang, F.-Q., Liang, H., Gupta, P. K., Havey, A., Boulton, M. E., & Godley, B. F. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6163 · Cited by 163 · see citing works
Viiri, J., Amadio, M., Marchesi, N., Hyttinen, J. M. T., Kivinen, N., Sironen, R. K., Rilla, K. J., Akhtar, S., Provenzani, A., D’Agostino, V., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069563 · Cited by 158 · see citing works
Mitochondria and autophagy: Critical interplay between the two homeostats
Okamoto, K., & Kondo‐Okamoto, N. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.08.001 · Cited by 154 · see citing works
Endoplasmic Reticulum Stress in Age-Related Macular Degeneration: Trigger for Neovascularization
Salminen, A., Kauppinen, A., Hyttinen, J. M. T., Toropainen, E., & Kaarniranta, K. (2010) · Molecular Medicine · doi:10.2119/molmed.2010.00070 · Cited by 138 · see citing works
Age-related macular degeneration: genome-wide association studies to translation
Black, J. R., & Clark, S. J. (2015) · Genetics in Medicine · doi:10.1038/gim.2015.70 · Cited by 137 · see citing works
Autophagy in the Retina: A Potential Role in Age-Related Macular Degeneration
Mitter, S. K., Rao, H. V., Qi, X., Cai, J., Sugrue, A., Dunn, W. A., Grant, M. B., & Boulton, M. E. (2012) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4614-0631-0_12 · Cited by 136 · see citing works
Nishikawa, T., Bellancé, N., Damm, A., Bing, H., Zhu, Z. H., Handa, K., Yovchev, M. I., Sehgal, V., Moss, T. J., Oertel, M., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.02.014 · Cited by 136 · see citing works
Wang, Y., Singh, R., Xiang, Y., & Czaja, M. J. (2010) · Hepatology · doi:10.1002/hep.23645 · Cited by 130 · see citing works
Identification of Novel Substrates for the Serine Protease HTRA1 in the Human RPE Secretome
An, E., Sen, S., Park, S. K., Gordish‐Dressman, H., & Hathout, Y. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4853 · Cited by 119 · see citing works
Experimental Serous Retinal Detachment and Focal Pigment Epithelial Damage
Negi, A., & Marmor, M. F. (1984) · Archives of Ophthalmology · doi:10.1001/archopht.1984.01040030359038 · Cited by 119 · see citing works
Molecular mechanisms of water transport in the eye
Hamann, S. (2002) · International review of cytology · doi:10.1016/s0074-7696(02)15016-9 · Cited by 118 · see citing works
Use of p62/SQSTM1 antibodies for neuropathological diagnosis
Kuusisto, E., Kauppinen, T., & Alafuzoff, I. I. (2007) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2007.00884.x · Cited by 113 · see citing works
Regulated expression of apolipoprotein E by human retinal pigment epithelial cells
Ishida, B. Y., Bailey, K. R., Duncan, K. G., Chalkley, R. J., Burlingame, A. L., Kane, J. P., & Schwartz, D. M. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300306-jlr200 · Cited by 111 · see citing works
Beta-galactosidase histochemistry and telomere loss in senescent retinal pigment epithelial cells.
Matsunaga, H., Handa, J. T., Aotaki-Keen, A. E., Sherwood, S. W., West, M. D., & Hjelmeland, L. M. (1999) · PubMed · Cited by 101 · see citing works
RPE cell senescence: A key contributor to age-related macular degeneration
Kozlowski, M. R. (2012) · Medical Hypotheses · doi:10.1016/j.mehy.2012.01.018 · Cited by 101 · see citing works
Johansson, I., Monsen, V. T., Pettersen, K., Mildenberger, J., Misund, K., Kaarniranta, K., Schønberg, S., & Bjørkøy, G. (2015) · Autophagy · doi:10.1080/15548627.2015.1061170 · Cited by 97 · see citing works
Wohlgemuth, S. E., Calvani, R., & Marzetti, E. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.03.007 · Cited by 97 · see citing works
Studying Age‐Related Macular Degeneration Using Animal Models
Fletcher, E. L., Jobling, A. I., Greferath, U., Mills, S. A., Waugh, M., Ho, T., de Iongh, R. U., Phipps, J. A., & Vessey, K. A. (2014) · Optometry and Vision Science · doi:10.1097/opx.0000000000000322 · Cited by 93 · see citing works
Notomi, S., Hisatomi, T., Murakami, Y., Terasaki, H., Sonoda, S., Asato, R., Takeda, A., Ikeda, Y., Enaida, H., Sakamoto, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053338 · Cited by 93 · see citing works
Fronk, A., & Vargis, E. (2016) · Journal of Tissue Engineering · doi:10.1177/2041731416650838 · Cited by 81 · see citing works
Age-Related Changes in the Retinal Pigment Epithelium (RPE)
Gu, X., Neric, N. J., Crabb, J. S., Crabb, J. W., Bhattacharya, S. K., Rayborn, M. E., Hollyfield, J. G., & Bonilha, V. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038673 · Cited by 80 · see citing works
Klotho Regulates Retinal Pigment Epithelial Functions and Protects Against Oxidative Stress
Kokkinaki, M., Abu-Asab, M. S., Gunawardena, N., Ahern, G. P., Javidnia, M., Young, J. K., & Golestaneh, N. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0402-13.2013 · Cited by 76 · see citing works
Self-citationA Novel Serum-Free Method for Culturing Human Prenatal Retinal Pigment Epithelial Cells
Gamm, D. M., Melvan, J. N., Shearer, R. L., Pinilla, I., Sabat, G., Svendsen, C. N., & Wright, L. S. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-0777 · Cited by 72 · see citing works
Wang, J., Ohno‐Matsui, K., & Morita, I. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.05.085 · Cited by 45 · see citing works
Sharma, N. K., Gupta, A., Prabhakar, S. K., Singh, R., Sharma, S., & Anand, A. (2012) · Current Neurovascular Research · doi:10.2174/156720212803530681 · Cited by 45 · see citing works
Evidence for enhanced tissue factor expression in age-related macular degeneration
Cho, Y., Cao, X., Shen, D., Tuo, J., Parver, L. M., Rickles, F. R., & Chan, C. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.184 · Cited by 41 · see citing works
Adenosine triphosphate‐induced photoreceptor death and retinal remodeling in rats
Vessey, K. A., Greferath, U., Aplin, F. P., Jobling, A. I., Phipps, J. A., Ho, T., de Iongh, R. U., & Fletcher, E. L. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23558 · Cited by 39 · see citing works
la Cour, M. (1993) · PubMed · Cited by 28 · see citing works
Noninvasive Imaging of Mitochondrial Dysfunction in Dry Age-Related Macular Degeneration
Field, M. G., Comer, G. M., Kawaji, T., Petty, H. R., & Elner, V. M. (2012) · Ophthalmic surgery, lasers & imaging retina · doi:10.3928/15428877-20120712-02 · Cited by 22 · see citing works
Human Retinal Pigment Epithelium in vitro: Influence of Low Oxygen Tension, Glucose and Insulin
Knorr, H. L. J., Linde-Behringer, M., Gossler, B., & Mayer, U. M. (2009) · Ophthalmic Research · doi:10.1159/000267318 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
Guo, J., Huang, X., Dou, L., Yan, M., Shen, T., Tang, W., & Li, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01251-0 · Cited by 1,834 · see citing works
Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration
Kaarniranta, K., Uusitalo, H. M. T., Błasiak, J., Felszeghy, S., Kannan, R., Kauppinen, A., Salminen, A., Sinha, D., & Ferrington, D. A. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100858 · Cited by 528 · see citing works
The cell biology of the retinal pigment epithelium
Lakkaraju, A., Umapathy, A., Tan, L. X., Daniele, L., Philp, N. J., Boesze-Battaglia, K., & Williams, D. S. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100846 · Cited by 422 · see citing works
Deng, Y., Qiao, L., Du, M., Qu, C., Wan, L., Li, J., & Huang, L. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2021.02.009 · Cited by 411 · see citing works
EMT and EndMT: Emerging Roles in Age-Related Macular Degeneration
Shu, D. Y., Butcher, E. R., & Saint‐Geniez, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124271 · Cited by 293 · see citing works
Functions and Diseases of the Retinal Pigment Epithelium
Yang, S., Zhou, J. Y., & Li, D. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.727870 · Cited by 257 · see citing works
A new perspective on lipid research in age-related macular degeneration
van Leeuwen, E. M., Emri, E., Merle, B. M. J., Colijn, J. M., Kersten, E., Cougnard-Gregoire, A., Dammeier, S., Meester-Smoor, M., Pool, F. M., de Jong, E. K., et al. (2018) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.04.006 · Cited by 247 · see citing works
Autophagy in age-related macular degeneration
Kaarniranta, K., Błasiak, J., Liton, P. B., Boulton, M. E., Klionsky, D. J., & Sinha, D. (2022) · Autophagy · doi:10.1080/15548627.2022.2069437 · Cited by 247 · see citing works
Retinal stem cell transplantation: Balancing safety and potential
Singh, M. S., Park, S. S., Albini, T. A., Canto-Soler, M. V., Klassen, H. J., MacLaren, R. E., Takahashi, M., Nagiel, A., Schwartz, S. D., & Bharti, K. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2019.100779 · Cited by 225 · see citing works
Perspective on AMD Pathobiology: A Bioenergetic Crisis in the RPE
Fisher, C. R., & Ferrington, D. A. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-24289 · Cited by 207 · see citing works
Kaarniranta, K., Pawłowska, E., Szczepańska, J., Jabłkowska, A., & Błasiak, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102374 · Cited by 193 · see citing works
Somasundaran, S., Constable, I. J., Mellough, C., & Carvalho, L. S. (2020) · Clinical and Experimental Ophthalmology · doi:10.1111/ceo.13834 · Cited by 195 · see citing works
Ferrington, D. A., Ebeling, M. C., Kapphahn, R. J., Terluk, M. R., Fisher, C. R., Polanco, J. R., Roehrich, H., Leary, M. M., Geng, Z., Dutton, J. R., et al. (2017) · Redox Biology · doi:10.1016/j.redox.2017.05.015 · Cited by 182 · see citing works
Abokyi, S., To, C. H., Lam, T. T., & Tse, D. Y. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/7901270 · Cited by 171 · see citing works
Chang, K., Liu, P., Chang, C., Lin, Y., Chen, Y., & Shu, C. (2022) · Cell & Bioscience · doi:10.1186/s13578-021-00736-9 · Cited by 168 · see citing works
Mitochondrial Defects Drive Degenerative Retinal Diseases
Ferrington, D. A., Fisher, C. R., & Kowluru, R. A. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.10.008 · Cited by 148 · see citing works
Błasiak, J., Pawłowska, E., Szczepańska, J., & Kaarniranta, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20010210 · Cited by 136 · see citing works
Dysregulated metabolic pathways in age-related macular degeneration
Zhang, M., Jiang, N., Chu, Y., Postnikova, O. A., Varghese, R. S., Horvath, A., Cheema, A. K., & Golestaneh, N. (2020) · Scientific Reports · doi:10.1038/s41598-020-59244-4 · Cited by 134 · see citing works
Self-citationWong, J. H. C., Jessica, Y. W., Jobling, A. I., Brandli, A. A., Greferath, U., Fletcher, E. L., & Vessey, K. A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1009599 · Cited by 110 · see citing works
Inducible and reversible phenotypes in a novel mouse model of Friedreich’s Ataxia
Chandran, V., Gao, K., Swarup, V., Versano, R., Dong, H., Jordan, M. C., & Geschwind, D. H. (2017) · eLife · doi:10.7554/elife.30054 · Cited by 96 · see citing works
Storti, F., Klee, K., Todorova, V., Steiner, R., Othman, A., van der Velde-Visser, S. D., Samardzija, M., Meneau, I., Barben, M., Karademir, D., et al. (2019) · eLife · doi:10.7554/elife.45100 · Cited by 97 · see citing works
Ghosh, S., Shang, P., Terasaki, H., Stepicheva, N. A., Hose, S., Yazdankhah, M., Weiss, J., Sakamoto, T., Bhutto, I. A., Xia, S., et al. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-24132 · Cited by 96 · see citing works
Role of Mitochondria in Retinal Pigment Epithelial Aging and Degeneration
Tong, Y., Zhang, Z., & Wang, S. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.926627 · Cited by 98 · see citing works
Fatty acid oxidation and photoreceptor metabolic needs
Fu, Z., Kern, T. S., Hellström, A., & Smith, L. E. H. (2020) · Journal of Lipid Research · doi:10.1194/jlr.tr120000618 · Cited by 98 · see citing works
Dyslipidemia in retinal metabolic disorders
Fu, Z., Chen, C. T., Cagnone, G., Heckel, É., Sun, Y., Cakir, B., Tomita, Y., Huang, S., Li, Q., Britton, W. R., et al. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201910473 · Cited by 92 · see citing works
Jadeja, R. N., Jones, M. A., Abdelrahman, A. A., Powell, F. L., Thounaojam, M. C., Gutsaeva, D. R., Bartoli, M., & Martin, P. M. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101336 · Cited by 92 · see citing works
Flores‐Bellver, M., Mighty, J., Aparicio‐Domingo, S., Li, K. V., Shi, C., Zhou, J., Cobb, H., McGrath, P. S., Michelis, G., Lenhart, P., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12165 · Cited by 87 · see citing works
Mammadzada, P., Corredoira, P. M. F., & André, H. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03422-9 · Cited by 90 · see citing works
Cheng, S.-Y., Cipi, J., Ma, S., Hafler, B. P., Kanadia, R., Brush, R. S., Agbaga, M., & Punzo, C. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2000339117 · Cited by 88 · see citing works
Wang, S., Wang, X., Cheng, Y., Ouyang, W., Sang, X., Liu, J., Su, Y., Liu, Y., Li, C., Yang, L., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3632169 · Cited by 83 · see citing works
Mitophagy in the retina: Viewing mitochondrial homeostasis through a new lens
Jiménez‐Loygorri, J. I., Benítez‐Fernández, R., Viedma-Poyatos, Á., Zapata‐Muñoz, J., Villarejo‐Zori, B., Gómez‐Sintes, R., & Boya, P. (2023) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2023.101205 · Cited by 83 · see citing works
Wang, L., & Mao, X. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052360 · Cited by 84 · see citing works
Mitochondrial dysfunction in age-related macular degeneration: melatonin as a potential treatment
Mehrzadi, S., Hemati, K., Reiter, R. J., & Hosseinzadeh, A. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1737015 · Cited by 81 · see citing works
A comparative map of macroautophagy and mitophagy in the vertebrate eye
McWilliams, T. G., Prescott, A. R., Villarejo‐Zori, B., Ball, G., Boya, P., & Ganley, I. G. (2019) · Autophagy · doi:10.1080/15548627.2019.1580509 · Cited by 80 · see citing works
Autophagy in Age-Related Macular Degeneration: A Regulatory Mechanism of Oxidative Stress
Zhang, Z.-Y., Bao, X.-L., Cong, Y.-Y., Fan, B., & Li, G. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2896036 · Cited by 80 · see citing works
Mitochondrial quality control in AMD: does mitophagy play a pivotal role?
Hyttinen, J. M. T., Viiri, J., Kaarniranta, K., & Błasiak, J. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2843-7 · Cited by 78 · see citing works
Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model
Sharma, R., George, A., Nimmagadda, M., Ortolan, D., Barbosa-Sabanero, K., Qureshy, Z., Bose, D., Dejene, R., Liang, G., Wan, Q., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27488-x · Cited by 78 · see citing works
Saada, J. I., McAuley, R. J., Marcatti, M., Tang, T. Z., Motamedi, M., & Szczęsny, B. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101523 · Cited by 77 · see citing works
Improving retinal mitochondrial function as a treatment for age-related macular degeneration
Ebeling, M. C., Polanco, J. R., Qu, J., Tu, C., Montezuma, S. R., & Ferrington, D. A. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101552 · Cited by 74 · see citing works
Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cells
Armento, A., Honisch, S., Panagiotakopoulou, V., Sonntag, I., Jacob, A., Bolz, S., Kilger, E., Deleidi, M., Clark, S. J., & Ueffing, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-67292-z · Cited by 74 · see citing works
Implication of Hyperhomocysteinemia in Blood Retinal Barrier (BRB) Dysfunction
Tawfik, A. M., Samra, Y. A., Elsherbiny, N. M., & Al‐Shabrawey, M. (2020) · Biomolecules · doi:10.3390/biom10081119 · Cited by 76 · see citing works
Pathophysiology of Age-Related Macular Degeneration: Implications for Treatment
Garcia-Garcia, J., Usategui‐Martín, R., Sanabria, M. R., Fernandez-Perez, E., Orriols, J. J. T., & Coco, R. M. (2022) · Ophthalmic Research · doi:10.1159/000524942 · Cited by 72 · see citing works
Aging of the eye: Lessons from cataracts and age-related macular degeneration
Cvekl, A., & Vijg, J. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102407 · Cited by 76 · see citing works
Tan, L. X., Germer, C. J., Cunza, N. L., & Lakkaraju, A. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101781 · Cited by 69 · see citing works
A Perspective of AMD Through the Eyes of Immunology
Copland, D. A., Theodoropoulou, S., Liu, J., & Dick, A. D. (2018) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.18-23893 · Cited by 66 · see citing works
Toma, C., Cillà, S. D., Palumbo, A., Garhwal, D. P., & Grossini, E. (2021) · Antioxidants · doi:10.3390/antiox10050653 · Cited by 66 · see citing works
La Cunza, N., Tan, L. X., Thamban, T., Germer, C. J., Rathnasamy, G., Toops, K. A., & Lakkaraju, A. (2021) · JCI Insight · doi:10.1172/jci.insight.142254 · Cited by 65 · see citing works
Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy
Hytti, M., Korhonen, E., Hyttinen, J. M. T., Roehrich, H., Kaarniranta, K., Ferrington, D. A., & Kauppinen, A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/1583656 · Cited by 64 · see citing works
Terluk, M. R., Ebeling, M. C., Fisher, C. R., Kapphahn, R. J., Yuan, C., Kartha, R. V., Montezuma, S. R., & Ferrington, D. A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5174957 · Cited by 64 · see citing works
Regulated efflux of photoreceptor outer segment-derived cholesterol by human RPE cells
Storti, F., Raphael, G., Griesser, V., Klee, K., Drawnel, F., Willburger, C., Scholz, R., Langmann, T., von Eckardstein, A., Fingerle, J., et al. (2017) · Experimental Eye Research · doi:10.1016/j.exer.2017.09.008 · Cited by 64 · see citing works
Maurya, M., Bora, K., Blomfield, A. K., Pavlovich, M. C., Huang, S., Liu, C.-H., & Chen, J. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.369098 · Cited by 63 · see citing works
He, W., Zhang, A., Qi, L., Chen, N., Jiang, R., Fan, Z., & Chen, J. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000487576 · Cited by 64 · see citing works
Lipids associated with autophagy: mechanisms and therapeutic targets
Jarocki, M., Turek, K., Saczko, J., Tarek, M., & Kulbacka, J. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02224-8 · Cited by 66 · see citing works
Pgc-1α repression and high-fat diet induce age-related macular degeneration-like phenotypes in mice
Zhang, M., Chu, Y., Mowery, J., Konkel, B., Galli, S., Theos, A. C., & Golestaneh, N. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.032698 · Cited by 61 · see citing works
Self-citationJahangiri, B., Saei, A. K., Obi, P. O., Asghari, N., Lorzadeh, S., Hekmatirad, S., Rahmati, M., Velayatipour, F., Asghari, M. H., Saleem, A., et al. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166484 · Cited by 60 · see citing works
Progress on ocular siRNA gene‐silencing therapy and drug delivery systems
Jiang, J., Zhang, X., Tang, Y., Li, S., & Chen, J. (2020) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12561 · Cited by 56 · see citing works
Zhou, B., Fang, L., Dong, Y., Yang, J., Chen, X., Zhang, N., Zhu, Y., & Huang, T. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03660-5 · Cited by 55 · see citing works
Chen, Q., Tang, L., Zhang, Y., Wan, C., Yu, X., Dong, Y., Chen, X., Wang, X., Li, N., Xin, G., et al. (2022) · Life Sciences · doi:10.1016/j.lfs.2021.120089 · Cited by 55 · see citing works
Adaptive and maladaptive roles of lipid droplets in health and disease
Pressly, J. D., Gurumani, M. Z., Santos, J. T. V., Fornoni, A., Merscher, S., & Al‐Ali, H. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00239.2021 · Cited by 55 · see citing works
Proteostasis in aging-associated ocular disease
Weinberg, J., Gaur, M., Swaroop, A., & Taylor, A. (2022) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2022.101157 · Cited by 54 · see citing works
Zhou, S., Taskintuna, K., Hum, J., Gulati, J., Olaya, S., Steinman, J., & Golestaneh, N. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06762-y · Cited by 54 · see citing works
Self-citationEbeling, M. C., Geng, Z., Kapphahn, R. J., Roehrich, H., Montezuma, S. R., Dutton, J. R., & Ferrington, D. A. (2021) · Cells · doi:10.3390/cells10040789 · Cited by 51 · see citing works
Si, Z., Zheng, Y., & Zhao, J. (2023) · Biomolecules · doi:10.3390/biom13060901 · Cited by 55 · see citing works
New insights into the role of autophagy in retinal and eye diseases
Villarejo‐Zori, B., Jiménez‐Loygorri, J. I., Zapata‐Muñoz, J., Bell, K. C., & Boya, P. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.101038 · Cited by 50 · see citing works
RPE melanin and its influence on the progression of AMD
Kaufmann, M., & Han, Z. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102358 · Cited by 54 · see citing works
Chen, S., Lin, T., Peng, H., Liu, H.-J., Lee, A., Lin, C., & Tseng, K. (2021) · Marine Drugs · doi:10.3390/md19020114 · Cited by 49 · see citing works
Shyam, R., Ogando, D. G., Choi, M., Liton, P. B., & Bonanno, J. A. (2021) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.62.12.15 · Cited by 48 · see citing works
CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function
Sethna, S., Scott, P. A., Giese, A. P. J., Duncan, T. E., Jian, X., Riazuddin, S. A., Randazzo, P. A., Redmond, T. M., Bernstein, S. L., Riazuddin, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24056-1 · Cited by 47 · see citing works
Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration
Rosales, M. A. B., Shu, D. Y., Iacovelli, J., & Saint‐Geniez, M. (2019) · Life Science Alliance · doi:10.26508/lsa.201800212 · Cited by 47 · see citing works
Zinc and Autophagy in Age-Related Macular Degeneration
Błasiak, J., Pawłowska, E., Chojnacki, J., Szczepańska, J., Chojnacki, C. J., & Kaarniranta, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144994 · Cited by 49 · see citing works
Romdhoniyyah, D. F., Harding, S. P., Cheyne, C. P., & Beare, N. A. V. (2021) · Ophthalmology and Therapy · doi:10.1007/s40123-021-00344-3 · Cited by 48 · see citing works
Zhang, Y., Huang, J., Liang, Y., Huang, J., Fu, Y., Chen, N., Lu, B., & Zhao, C. (2023) · Autophagy · doi:10.1080/15548627.2023.2220540 · Cited by 44 · see citing works
Zhang, K. R., Jankowski, C. S. R., Marshall, R. F., Nair, R. M., Gómez, N. M., Alnemri, A. G., Liu, Y., Erler, E. A., Ferrante, J. R., Song, Y., et al. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.050066 · Cited by 44 · see citing works
Eye on the horizon: The metabolic landscape of the RPE in aging and disease
Hansman, D., Du, J., Casson, R. J., & Peet, D. J. (2024) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2024.101306 · Cited by 48 · see citing works
The Aging Stress Response and Its Implication for AMD Pathogenesis
Błasiak, J., Pawłowska, E., Sobczuk, A., Szczepańska, J., & Kaarniranta, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228840 · Cited by 44 · see citing works
Kurzawa‐Akanbi, M., Whitfield, P. D., Burté, F., Bertelli, P. M., Pathak, V., Doherty, M. K., Hilgen, B., Gliaudelytė, L., Platt, M., Queen, R. A., et al. (2022) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12295 · Cited by 43 · see citing works
Amini, M. A., Karbasi, A., Vahabirad, M., Khanaghaei, M., & Alizamir, A. (2023) · Chonnam Medical Journal · doi:10.4068/cmj.2023.59.3.143 · Cited by 43 · see citing works
Zinc deficiency as possible link between immunosenescence and age-related diseases
Schulz, M. T., & Rink, L. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00511-1 · Cited by 46 · see citing works
Du, Y., You, L., Ni, B., Sai, N., Wang, W., Sun, M., Xu, R., Yao, Y., Zhang, Z., Qu, C., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2684672 · Cited by 42 · see citing works
Epigenetic regulation of retinal development
Raeisossadati, R., Ferrari, M., Kihara, A. H., Aldiri, I., & Gross, J. M. (2021) · Epigenetics & Chromatin · doi:10.1186/s13072-021-00384-w · Cited by 42 · see citing works
Xia, W., Li, C., Chen, Q., Huang, J., Zhao, Z., Liu, P., Xu, K., Li, L., Hu, F., Zhang, S., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.10.022 · Cited by 42 · see citing works
Chuang, J.-Z., Yang, N., Nakajima, N., Otsu, W., Fu, C., Yang, H. H., Lee, M. P., Akbar, A. F., Badea, T. C., Guo, Z., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27935-9 · Cited by 42 · see citing works
Human retinal model systems: Strengths, weaknesses, and future directions
Eldred, K. C., & Reh, T. A. (2021) · Developmental Biology · doi:10.1016/j.ydbio.2021.09.001 · Cited by 41 · see citing works
Dhingra, A., Bell, B. A., Peachey, N. S., Daniele, L. L., Reyes-Reveles, J., Sharp, R. C., Jun, B., Bazan, N. G., Sparrow, J. R., Kim, H. J., et al. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00351 · Cited by 41 · see citing works
Oxidative stress and mitochondrial transfer: A new dimension towards ocular diseases
Subramaniam, M. D., Iyer, M., Nair, A. P., Venkatesan, D., Mathavan, S., Eruppakotte, N., Kizhakkillach, S., Chandran, M. K., Roy, A., Gopalakrishnan, A. V., et al. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2020.11.020 · Cited by 41 · see citing works
Kurzawa‐Akanbi, M., Tzoumas, N., Corral-Serrano, J. C., Guarascio, R., STEEL, D. H., Cheetham, M. E., Armstrong, L., & Lako, M. (2024) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2024.101248 · Cited by 40 · see citing works
Harnessing the Neuroprotective Behaviors of Müller Glia for Retinal Repair
Peña, J. S., & Vázquez, M. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2706169 · Cited by 38 · see citing works
Low-Luminance Blue Light-Enhanced Phototoxicity in A2E-Laden RPE Cell Cultures and Rats
Lin, C., Wu, M.-R., Huang, W., Chow, D. S., Hsiao, G., & Cheng, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071799 · Cited by 40 · see citing works
Saito, Y., Yako, T., Otsu, W., Nakamura, S., Inoue, Y., Muramatsu, A., Nakagami, Y., Shimazawa, M., & Hara, H. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.03.012 · Cited by 39 · see citing works
Beyond the Liver: Liver-Eye Communication in Clinical and Experimental Aspects
Yuan, T.-H., Yue, Z., Zhang, G.-H., Wang, L., & Dou, G. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.823277 · Cited by 38 · see citing works
Diéguez, H. H., Romeo, H. E., Alaimo, A., Fleitas, M. F. G., Aranda, M. L., Rosenstein, R. E., & Dorfman, D. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.11.035 · Cited by 38 · see citing works
Sinha, T., Naash, M. I., & Al‐Ubaidi, M. R. (2020) · iScience · doi:10.1016/j.isci.2020.101004 · Cited by 38 · see citing works
Kozhevnikova, O. S., Telegina, D. V., Devyatkin, V. A., & Kolosova, N. G. (2018) · Biogerontology · doi:10.1007/s10522-018-9751-y · Cited by 37 · see citing works
Phagocytosed photoreceptor outer segments activate mTORC1 in the retinal pigment epithelium
Yu, B., Egbejimi, A., Dharmat, R., Xu, P., Zhao, Z., Long, B., Miao, H., Chen, R., Wensel, T. G., Cai, J., et al. (2018) · Science Signaling · doi:10.1126/scisignal.aag3315 · Cited by 37 · see citing works
Cai, J., Zhang, H., Zhang, Y. F., Zhou, Z., & Wu, S. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.11.028 · Cited by 37 · see citing works
Nerve Growth Factor-Based Therapy in Alzheimer’s Disease and Age-Related Macular Degeneration
Amadoro, G., Latina, V., Balzamino, B. O., Squitti, R., Varano, M., Calissano, P., & Micera, A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.735928 · Cited by 40 · see citing works
Lipid Droplet Accumulation Promotes RPE Dysfunction
Yako, T., Otsu, W., Nakamura, S., Shimazawa, M., & Hara, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031790 · Cited by 37 · see citing works
Catanzaro, M., Lanni, C., Basagni, F., Rosini, M., Govoni, S. M., & Amadio, M. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00844 · Cited by 36 · see citing works
Long-Term Progression of Pericentral Hydroxychloroquine Retinopathy
Ahn, S. J., Seo, E. J., Kim, K. E., Kim, K. G., Lee, B. R., Kim, J.-G., Yoon, Y. H., & Lee, J. Y. (2020) · Ophthalmology · doi:10.1016/j.ophtha.2020.10.029 · Cited by 36 · see citing works
Saptarshi, N., Porter, L. F., & Paraoan, L. (2022) · Scientific Reports · doi:10.1038/s41598-022-16909-6 · Cited by 35 · see citing works
- Authors
- Golestaneh, N., Chu, Y., Xiao, Y.-Y., Stoleru, G. L., & Theos, A. C.
- Affiliations
- Georgetown University Medical Center (US)
- Georgetown University (US)
- Corresponding author
- Golestaneh, Nady
- Venue
- Cell Death & Disease
- Published
- 2017-01-05
- Volume
- 8
- Issue
- 1
- Pages
- e2537-e2537
- ISSN
- 2041-4889 (ISSN-L)
- PMC
- PMC5386365
- OpenAlex
- W2569601267
- Cited by
- 357
- References
- 83
- Citations by year
- 2026: 35 · 2025: 31 · 2024: 41 · 2023: 31 · 2022: 51 · 2021: 52 · 2020: 61 · 2019: 25 · 2018: 23 · 2017: 7
- FWCI
- 24.85
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Cell Death and Disease (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- BrightFocus Foundation
- Children's National Hospital
- National Institutes of Health
- National Eye Institute
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- age-related macular degeneration, retinal pigment epithelium, autophagy dysfunction, autophagic flux, lipid droplets, glycogen granules, mitochondrial dysfunction, oxidative stress, reactive oxygen species, LC3-II/LC3-I ratio, p62, LAMP1, lysosomes, AMD pathogenesis
- MeSH terms
- Autophagosomes, Cells, Cultured, Glycogen, Humans, Macular Degeneration, Mitochondria, Reactive Oxygen Species, Oxidative Stress, Lysosomal Membrane Proteins, Lysosomal-Associated Membrane Protein 1, Retinal Pigment Epithelium, Lipid Droplets
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
