The DOI matches its Crossref record; 41 of the 43 references it cites were found in a registry or an index.
Anti-pigmentary activity of fucoxanthin and its influence on skin mRNA expression of melanogenic molecules
Abstract
Objectives: Carotenoids and retinoic acid derivatives are topically applied for sun-protective and whitening purposes. Fucoxanthin is a carotenoid derived from edible sea algae, but its effect on melanogenesis has not been established. Therefore, we examined the effect of fucoxanthin on melanogenesis. Methods: Inhibitory effects on tyrosinase activity, melanin formation in B16 melanoma and skin pigmentation in UVB-irradiated guinea-pigs were evaluated. To elucidate the action of fucoxanthin on melanogenesis, its effect on skin melanogenic mRNA expression was evaluated in UVB-irradiated mice. Fucoxanthin was given topically or orally to mice once a day and UVB irradiation was applied for 14 days. The effect of fucoxanthin on skin melanogenic mRNA expression was evaluated by real time reverse transcription polymerase chain reaction. Key findings: Fucoxanthin inhibited tyrosinase activity, melanogenesis in melanoma and UVB-induced skin pigmentation. Topical application of fucoxanthin (1%) significantly suppressed mRNA expression of cyclooxygenase (COX)-2, endothelin receptor A, p75 neurotrophin receptor (NTR), prostaglandin E receptor 1 (EP1), melanocortin 1 receptor (MC1R) and tyrosinase-related protein 1. The suppression of p75NTR, EP1 and MC1R expressions was observed at 0.01% application. Also, oral application of fucoxanthin (10 mg/kg) significantly suppressed expression of COX-2, p75NTR, EP1 and MC1R. Conclusions: These results suggest that fucoxanthin exhibits anti-pigmentary activity by topical or oral application in UVB-induced melanogenesis. This effect of fucoxanthin may be due to suppression of prostaglandin (PG) E2 synthesis and melanogenic stimulant receptors (neurotrophin, PGE2 and melanocyte stimulating hormone expression).
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“It inhibits skin melanogenesis by negative regulation of the transcriptional factors involved [236].”
From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [236]
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Metadata
- Authors
- Shimoda, H., Tanaka, J., Shan, S.-J., & Maoka, T.
- Affiliations
- Oryza (Japan) (JP)
- Research Institute for Production Development (JP)
- Corresponding author
- Shimoda, Hiroshi
- Venue
- Journal of Pharmacy and Pharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-09-01
- Volume
- 62
- Issue
- 9
- Pages
- 1137-1145
- ISSN
- 0022-3573 (ISSN-L)
- 2042-7158
- OpenAlex
- W1947307437
- Cited by
- 152
- References
- 43
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 15 · 2023: 19 · 2022: 14 · 2021: 9 · 2020: 18 · 2019: 9 · 2018: 12 · 2017: 6 · 2016: 1 · 2015: 5 · 2014: 4 · 2013: 8 · 2012: 6
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Pharmacy and Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Helmholtz Centre for Ocean Research Kiel (GEOMAR) (acceptedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Keywords
- fucoxanthin, melanogenesis, tyrosinase inhibition, carotenoids, cyclooxygenase-2, prostaglandin E2, p75 neurotrophin receptor, EP1 receptor, MC1R, TRP-1, B16 melanoma, topical application, oral administration, skin lightening
- MeSH terms
- Phaeophyceae, Animals, Antineoplastic Agents, Phytogenic, Guinea Pigs, Male, Phytotherapy, Melanins, Melanoma, Mice, Hairless, Plant Extracts, RNA, Messenger, Skin, Skin Pigmentation, Monophenol Monooxygenase, Ultraviolet Rays, Gene Expression, Receptors, Endothelin, Reverse Transcriptase Polymerase Chain Reaction, Receptor, Nerve Growth Factor, Xanthophylls, Receptor, Melanocortin, Type 1, Mice, Cyclooxygenase 2, Receptors, Prostaglandin E, EP1 Subtype
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