Cited by 152melanin and skin pigmentationSkin Protection and AgingMelanoma and MAPK Pathways

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Anti-pigmentary activity of fucoxanthin and its influence on skin mRNA expression of melanogenic molecules

Shimoda, Hiroshi, Tanaka, Junji, Shan, Shao-Jie, Maoka, Takashi·2010·Journal of Pharmacy and Pharmacology

DOI 10.1111/j.2042-7158.2010.01139.x

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Abstract

Objectives: Carotenoids and retinoic acid derivatives are topically applied for sun-protective and whitening purposes. Fucoxanthin is a carotenoid derived from edible sea algae, but its effect on melanogenesis has not been established. Therefore, we examined the effect of fucoxanthin on melanogenesis. Methods: Inhibitory effects on tyrosinase activity, melanin formation in B16 melanoma and skin pigmentation in UVB-irradiated guinea-pigs were evaluated. To elucidate the action of fucoxanthin on melanogenesis, its effect on skin melanogenic mRNA expression was evaluated in UVB-irradiated mice. Fucoxanthin was given topically or orally to mice once a day and UVB irradiation was applied for 14 days. The effect of fucoxanthin on skin melanogenic mRNA expression was evaluated by real time reverse transcription polymerase chain reaction. Key findings: Fucoxanthin inhibited tyrosinase activity, melanogenesis in melanoma and UVB-induced skin pigmentation. Topical application of fucoxanthin (1%) significantly suppressed mRNA expression of cyclooxygenase (COX)-2, endothelin receptor A, p75 neurotrophin receptor (NTR), prostaglandin E receptor 1 (EP1), melanocortin 1 receptor (MC1R) and tyrosinase-related protein 1. The suppression of p75NTR, EP1 and MC1R expressions was observed at 0.01% application. Also, oral application of fucoxanthin (10 mg/kg) significantly suppressed expression of COX-2, p75NTR, EP1 and MC1R. Conclusions: These results suggest that fucoxanthin exhibits anti-pigmentary activity by topical or oral application in UVB-induced melanogenesis. This effect of fucoxanthin may be due to suppression of prostaglandin (PG) E2 synthesis and melanogenic stimulant receptors (neurotrophin, PGE2 and melanocyte stimulating hormone expression).

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Costin, G.-E., & Hearing, V. J. (2007) · The FASEB Journal · doi:10.1096/fj.06-6649rev · Cited by 976
Physiological factors that regulate skin pigmentation
Yamaguchi, Y., & Hearing, V. J. (2009) · BioFactors · doi:10.1002/biof.29 · Cited by 495
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Protective effect of fucoxanthin isolated from Sargassum siliquastrum on UV-B induced cell damage
Heo, S.-J., & Jeon, Y.-J. (2009) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/j.jphotobiol.2008.11.011 · Cited by 293
Lutein and zeaxanthin in eye and skin health
Roberts, R. L., Green, J. A., & Lewis, B. (2009) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2008.01.011 · Cited by 276
Beneficial long-term effects of combined oral/topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: A double-blind, placebo-controlled study
Palombo, P., Fabrizi, G., Ruocco, V., Ruocco, E., Fluhr, J., Roberts, R., & Morganti, P. (2007) · Skin Pharmacology and Physiology · doi:10.1159/000101807 · Cited by 253
The distribution and accumulation of fucoxanthin and its metabolites after oral administration in mice
Hashimoto, T., Ozaki, Y., Taminato, M., Das, S. K., Mizuno, M., Yoshimura, K., Maoka, T., & Kanazawa, K. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114508199007 · Cited by 181
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Proopiomelanocortin (POMC), the ACTH/ melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis
Rousseau, K., Kauser, S., Pritchard, L. E., Warhurst, A., Oliver, R. L., Slominski, A. T., Wei, E. T., Thody, A. J., Tobin, D. J., & White, A. E. (2007) · The FASEB Journal · doi:10.1096/fj.06-7398com · Cited by 178
The Role of Endothelin‐1 in Epidermal Hyperpigmentation and Signaling Mechanisms of Mitogenesis and Melanogenesis
Imokawa, G., Kobayashi, T., Miyagishi, M., Higashi, K., & Yada, Y. (1997) · Pigment Cell Research · doi:10.1111/j.1600-0749.1997.tb00488.x · Cited by 175
Astaxanthin, canthaxanthin and β‐carotene differently affect UVA‐induced oxidative damage and expression of oxidative stress‐responsive enzymes
Camera, E., Mastrofrancesco, A., Fabbri, C., Daubrawa, F., Picardo, M., Sies, H., & Stahl, W. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00790.x · Cited by 172

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Authors: Shimoda, H., Tanaka, J., Shan, S.-J., & Maoka, T.
Affiliations: Oryza (Japan) (JP)
Research Institute for Production Development (JP)
Corresponding author: Shimoda, Hiroshi
ORCID: Shimoda, Hiroshi
Tanaka, Junji
Venue: Journal of Pharmacy and Pharmacology
Publisher: Oxford University Press (OUP)
Published: 2010-09-01
Volume: 62
Issue: 9
Pages: 1137-1145
ISSN: 0022-3573 (ISSN-L)
2042-7158
DOI: 10.1111/j.2042-7158.2010.01139.x
OpenAlex: W1947307437
Cited by: 152
References: 43
Citations by year: 2026: 9 · 2025: 8 · 2024: 15 · 2023: 19 · 2022: 14 · 2021: 9 · 2020: 18 · 2019: 9 · 2018: 12 · 2017: 6 · 2016: 1 · 2015: 5 · 2014: 4 · 2013: 8 · 2012: 6
FWCI: 3.22
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Journal of Pharmacy and Pharmacology (publishedVersion)
PubMed (publishedVersion)
Helmholtz Centre for Ocean Research Kiel (GEOMAR) (acceptedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
Keywords: fucoxanthin, melanogenesis, tyrosinase inhibition, carotenoids, cyclooxygenase-2, prostaglandin E2, p75 neurotrophin receptor, EP1 receptor, MC1R, TRP-1, B16 melanoma, topical application, oral administration, skin lightening
MeSH terms: Phaeophyceae, Animals, Antineoplastic Agents, Phytogenic, Guinea Pigs, Male, Phytotherapy, Melanins, Melanoma, Mice, Hairless, Plant Extracts, RNA, Messenger, Skin, Skin Pigmentation, Monophenol Monooxygenase, Ultraviolet Rays, Gene Expression, Receptors, Endothelin, Reverse Transcriptase Polymerase Chain Reaction, Receptor, Nerve Growth Factor, Xanthophylls, Receptor, Melanocortin, Type 1, Mice, Cyclooxygenase 2, Receptors, Prostaglandin E, EP1 Subtype

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Anti-pigmentary activity of fucoxanthin and its influence on skin mRNA expression of melanogenic molecules

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