Cited by 293Skin Protection and AgingSeaweed-derived Bioactive CompoundsAntioxidant Activity and Oxidative Stress

Protective effect of fucoxanthin isolated from Sargassum siliquastrum on UV-B induced cell damage

Heo, Soo-Jin, Jeon, You-Jin·2009·Journal of Photochemistry and Photobiology B: Biology

Abstract

Fucoxanthin is a carotenoid isolated from Sargassum siliquastrum and is considered to be one of major active compound of marine algae. In this study, we investigated and confirmed the protective effect of fucoxanthin on UV-B induced cell injury in human fibroblast via 2',7'-dichlorodihydrofluorescein diacetate (DCFH-DA), 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide (MTT), and comet assays. Intracellular ROS generated by exposure to UV-B radiation, which was significantly decreased by addition with various concentrations of fucoxanthin. Cell survival rate was increased with fucoxanthin pre-treated cells, which was reached around 81.47% at 100 microM, and the inhibitory effect of cell damage exhibited dose-dependent manner. Moreover, fucoxanthin having protective properties was demonstrated via Hoechst 33342/PI staining. Hence, on the basis of the above-mentioned studies, fucoxanthin has the ability to protect against oxidative stress induced by UV-B radiation and which might be applied to antioxidant and cosmeceutical industries.

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Crossref · 10.1016/j.jphotobiol.2008.11.011

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Authors
Heo, S.-J., & Jeon, Y.-J.
Affiliations
  • Korea Institute of Ocean Science and Technology (KR)
  • Jeju National University (KR)
Corresponding author
Jeon, You-Jin
Venue
Journal of Photochemistry and Photobiology B: Biology
Publisher
Elsevier BV
Published
2009-05
Volume
95
Issue
2
Pages
101-107
ISSN
1011-1344 (ISSN-L)
OpenAlex
W2094954610
Cited by
293
References
31
Citations by year
2026: 11 · 2025: 18 · 2024: 11 · 2023: 18 · 2022: 26 · 2021: 30 · 2020: 30 · 2019: 16 · 2018: 22 · 2017: 17 · 2016: 5 · 2015: 13 · 2014: 12 · 2013: 20 · 2012: 10
FWCI
12.11
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Photochemistry and Photobiology B Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
fucoxanthin, Sargassum siliquastrum, UV-B radiation, photoprotection, oxidative stress, reactive oxygen species, human fibroblasts, cell damage, antioxidants, carotenoids, cosmeceuticals
MeSH terms
Cell Line, Cell Survival, DNA Damage, Fibroblasts, Humans, Radiation-Protective Agents, Ultraviolet Rays, Reactive Oxygen Species, Oxidative Stress, Comet Assay, Xanthophylls, Sargassum

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