Protective effect of fucoxanthin isolated from Sargassum siliquastrum on UV-B induced cell damage
Abstract
Fucoxanthin is a carotenoid isolated from Sargassum siliquastrum and is considered to be one of major active compound of marine algae. In this study, we investigated and confirmed the protective effect of fucoxanthin on UV-B induced cell injury in human fibroblast via 2',7'-dichlorodihydrofluorescein diacetate (DCFH-DA), 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide (MTT), and comet assays. Intracellular ROS generated by exposure to UV-B radiation, which was significantly decreased by addition with various concentrations of fucoxanthin. Cell survival rate was increased with fucoxanthin pre-treated cells, which was reached around 81.47% at 100 microM, and the inhibitory effect of cell damage exhibited dose-dependent manner. Moreover, fucoxanthin having protective properties was demonstrated via Hoechst 33342/PI staining. Hence, on the basis of the above-mentioned studies, fucoxanthin has the ability to protect against oxidative stress induced by UV-B radiation and which might be applied to antioxidant and cosmeceutical industries.
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Fucoxanthin protects DNA from photooxidation.
“Moreover, fucoxanthin has been shown to protect DNA from photooxidation [237].”
From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [237]
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- Authors
- Heo, S.-J., & Jeon, Y.-J.
- Affiliations
- Korea Institute of Ocean Science and Technology (KR)
- Jeju National University (KR)
- Corresponding author
- Jeon, You-Jin
- Venue
- Journal of Photochemistry and Photobiology B: Biology
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 95
- Issue
- 2
- Pages
- 101-107
- ISSN
- 1011-1344 (ISSN-L)
- OpenAlex
- W2094954610
- Cited by
- 293
- References
- 31
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 11 · 2023: 18 · 2022: 26 · 2021: 30 · 2020: 30 · 2019: 16 · 2018: 22 · 2017: 17 · 2016: 5 · 2015: 13 · 2014: 12 · 2013: 20 · 2012: 10
- FWCI
- 12.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Photochemistry and Photobiology B Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- fucoxanthin, Sargassum siliquastrum, UV-B radiation, photoprotection, oxidative stress, reactive oxygen species, human fibroblasts, cell damage, antioxidants, carotenoids, cosmeceuticals
- MeSH terms
- Cell Line, Cell Survival, DNA Damage, Fibroblasts, Humans, Radiation-Protective Agents, Ultraviolet Rays, Reactive Oxygen Species, Oxidative Stress, Comet Assay, Xanthophylls, Sargassum
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