The DOI matches its Crossref record; 185 of the 185 references it cites were found in a registry or an index.
Pseudomonas aeruginosa Biofilms
Open accessAbstract
Pseudomonas aeruginosa is an opportunistic human pathogen causing devastating acute and chronic infections in individuals with compromised immune systems. Its highly notorious persistence in clinical settings is attributed to its ability to form antibiotic-resistant biofilms. Biofilm is an architecture built mostly by autogenic extracellular polymeric substances which function as a scaffold to encase the bacteria together on surfaces, and to protect them from environmental stresses, impedes phagocytosis and thereby conferring the capacity for colonization and long-term persistence. Here we review the current knowledge on P. aeruginosa biofilms, its development stages, and molecular mechanisms of invasion and persistence conferred by biofilms. Explosive cell lysis within bacterial biofilm to produce essential communal materials, and interspecies biofilms of P. aeruginosa and commensal Streptococcus which impedes P. aeruginosa virulence and possibly improves disease conditions will also be discussed. Recent research on diagnostics of P. aeruginosa infections will be investigated. Finally, therapeutic strategies for the treatment of P. aeruginosa biofilms along with their advantages and limitations will be compiled.
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Cites
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Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development
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Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies
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Metadata
- Authors
- Thi, M. T. T., Wibowo, D., & Rehm, B. H. A.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-11-17
- Volume
- 21
- Issue
- 22
- Pages
- 8671
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W3102032040
- Cited by
- 911
- References
- 185
- FWCI
- 24.27
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
