Shift in skin microbiota of Western European women across aging
Open accessAbstract
AIMS: The objective of our study was to compare the microbiota diversity between two different age groups of Western European women. METHODS AND RESULTS: Skin-swab samples were collected directly on the forehead of 34 healthy Western European women: 17 younger (21-31 years old) and 17 older individuals (54-69 years old). Bacterial communities were evaluated using the 16S rRNA gene sequencing. Data revealed a higher alpha diversity on the skin of older individuals compared with younger ones. Overall microbiota structure was different between the two age groups, as demonstrated by beta diversity analysis, which also highlighted a high interpersonal variation within older individuals. Furthermore, taxonomic composition analysis showed both an increase in Proteobacteria and a decrease in Actinobacteria on the older skin. At the genus level, older skin exhibited a significant increase in Corynebacterium and a decrease in Propionibacterium relative abundance. CONCLUSIONS: Our study revealed a shift in the distribution of skin microbiota during chronological aging in Western European women. SIGNIFICANCE AND IMPACT OF STUDY: Altogether these results could become the basis to develop new approaches aiming to rebalance the skin microbiota, which is modified during the aging process.
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Proteobacteria and Corynebacterium were reported to be the predominant phylum and genus, respectively, on the skin with aging.
“Proteobacteria and Corynebacterium were reported to be the predominant phylum and genus, respectively, on the skin with aging [60,61].”
From Host–Candida auris interactions in the skin (2026) · cites this paper as [60]
Cites
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Temporal Stability of the Human Skin Microbiome
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Diversity of the human skin microbiome early in life
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Vollmer, D. L., West, V. A., & Lephart, E. D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103059 · Cited by 132 · see citing works
Host–Candida auris interactions in the skin
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- Authors
- Jugé, R., Rouaud-Tinguely, P., Breugnot, J., Servaes, K., Grimaldi, C., Roth, M.-P., Coppin, H., & Closs, B.
- Affiliations
- Silab (France) (FR)
- R&D department; SILAB; Brive-la-Gaillarde France
- Inserm (FR)
- Venue
- Journal of Applied Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-06-29
- Volume
- 125
- Issue
- 3
- Pages
- 907-916
- ISSN
- 1364-5072 (ISSN-L)
- OpenAlex
- W2804611869
- Cited by
- 112
- References
- 7
- Citations by year
- 2026: 6 · 2025: 16 · 2024: 19 · 2023: 16 · 2022: 13 · 2021: 26 · 2020: 8 · 2019: 6 · 2018: 2
- FWCI
- 11.69
- Type
- journal article
- Language
- en
- Open access
- green
- hal.inrae.fr
- Licence
- Locations
- Journal of Applied Microbiology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- skin microbiome, chronological aging, women, bacterial diversity, Proteobacteria, actinobacteria, Corynebacterium, Propionibacterium, Western Europe
- MeSH terms
- Adult, Aged, Aging, Bacteria, Europe, Female, Humans, Middle Aged, Skin, Young Adult, Microbiota
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