Cholesterol homeostasis associated with probiotic supplementation in vivo
Abstract
AIMS: To determine the mechanism underlying the serum cholesterol reduction effect by probiotics isolated from local fermented tapioca (Tapai). METHODS AND RESULTS: Lactic acid bacteria strains were isolated and examined for acid tolerance, bile salt resistance and hypocholesterolemic properties. Among the isolates, Lactobacillus plantarum TAR4 showed the highest cholesterol reduction ability (48·01%). The focus in the in vivo trial was to elucidate the cholesterol balance from findings pertaining to serum cholesterol reduction in rat model fed with high fat diet via oral administration. Rats fed with high-cholesterol diet supplemented with Lact. plantarum TAR4 showed significant reduction in serum total cholesterol (29·55%), serum triglyceride (45·31%) and liver triglyceride (23·44%) as compared to high-cholesterol diet (HCD) group. There was a significant increment in faecal triglyceride (45·83%) and faecal total bile acid (384·95%) as compared to HCD group. CONCLUSIONS: The findings showed that probiotic Lact. plantarum TAR4 supplementation reduced the absorption of bile acids for enterohepatic recycling and increased the catabolism of cholesterol to bile acids and not by suppressing the rate of cholesterol synthesis. SIGNIFICANCE AND IMPACT OF STUDY: Probiotic supplements could provide a new nonpharmacological alternative to reduce cardiovascular risk factors.
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Lactobacillus induces activation of the Farnesoid X receptor, leading to downregulation of CYP7A1 and CYP8B1 expression, which ultimately results in decreased cholesterol levels in vivo.
“Lactobacillus induces activation of the Farnesoid X receptor, leading to the downregulation of the expression of key enzymes in bile acid synthesis, namely cholesterol-7α-hydroxylase (CYP7A1) and sterol-12α-hydroxylase (CYP8B1). This modulation ultimately results in decreased cholesterol levels in vivo (Lim et al., 2020).”
From Lactiplantibacillus plantarum N4 ameliorates lipid metabolism and gut microbiota structure in high fat diet-fed rats (2024) · cites this paper as Lim et al., 2020
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甘, 涛. (2022) · Hans Journal of Food and Nutrition Science · doi:10.12677/hjfns.2022.113024
- Authors
- Lim, P. S., Loke, C. F., Ho, Y. W., & Tan, H. Y.
- Affiliations
- Tunku Abdul Rahman University of Management and Technology (MY)
- Universiti Putra Malaysia (MY)
- Corresponding author
- Tan, H.Y.
- Venue
- Journal of Applied Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-06-10
- Volume
- 129
- Issue
- 5
- Pages
- 1374-1388
- ISSN
- 1364-5072 (ISSN-L)
- 1365-2672
- OpenAlex
- W3023730658
- Cited by
- 26
- References
- 67
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 2
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Applied Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Higher Education, Malaysia (FRGS/2/2014/SG05/TARUC/02/1 (FRGS 76007))
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- probiotics, cholesterol homeostasis, serum cholesterol reduction, Lactobacillus plantarum, tapai, enterohepatic circulation, high-cholesterol diet, triglycerides, bile salt tolerance, acid resistance, cardiovascular risk factors
- MeSH terms
- Fermented Foods, Animals, Bile Acids and Salts, Manihot, Cholesterol, Homeostasis, Triglycerides, Dietary Supplements, Probiotics, Lactiplantibacillus plantarum, Lactobacillus plantarum, Lipid Metabolism, Rats, Lactobacillales, Diet, High-Fat
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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