Cited by 124Probiotics and Fermented FoodsGut microbiota and healthSteroid Chemistry and Biochemistry

Bile Salt Hydrolase (Bsh) Activity Screening of Lactobacilli: In Vitro Selection of Indigenous Lactobacillus Strains with Potential Bile Salt Hydrolysing and Cholesterol-Lowering Ability

Kumar, Rajesh, Grover, Sunita, Batish, Virender Kumar·2012·Probiotics and Antimicrobial Proteins

Abstract

The bile salt hydrolase (Bsh) activity of probiotic bacterium residing in gastrointestinal tract has often being associated with its cholesterol-lowering effects. Hence, Bsh activity was explored in this study as the criterion for the selection of most potential Bsh-active and cholesterol-lowering indigenous Lactobacillus strains. Forty lactobacilli were adjudged Bsh active after a preliminary screening of 102 lactobacilli and occurrence of Bsh activity correlated well with their natural habitats. Of the 40 shortlisted lactobacilli, fifteen putative Lactobacillus strains were selected and further tested for their comparative Bsh activity. In the end, indigenous Lactobacillus plantarum strains Lp91 and Lp21 were emerged as the promising Bsh-active lactobacilli with their substrate preference inclined more towards glycocholate than other bile acid amino conjugates. In addition, strains Lp91 and Lp21 also exhibited significantly high bile salt deconjugation, cholesterol assimilation and cholesterol co-precipitation ability in vitro. In conclusion, indigenous L. plantarum strains Lp91 and Lp21 may be the promising candidate probiotics to elucidate the ecological significance of probiotic Bsh activity in vivo.

Integrity signals

Registry

Crossref · 10.1007/s12602-012-9101-3

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Kumar, R., Grover, S., & Batish, V. K.
Affiliations
National Dairy Research Institute (IN)
Corresponding author
  • Kumar, Rajesh
  • Batish, Virender Kumar
Venue
Probiotics and Antimicrobial Proteins
Published
2012-04-21
Volume
4
Issue
3
Pages
162-172
ISSN
  • 1867-1306 (ISSN-L)
  • 1867-1314
OpenAlex
W2081706251
Cited by
123
References
41
Citations by year
2026: 16 · 2025: 17 · 2024: 15 · 2023: 9 · 2022: 7 · 2021: 9 · 2020: 8 · 2019: 7 · 2018: 6 · 2017: 6 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 9 · 2012: 1
FWCI
9.34
Type
journal article
Language
en
Open access
closed
Locations
  • Probiotics and Antimicrobial Proteins (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
Keywords
bile salt hydrolase, Lactobacillus plantarum, cholesterol-lowering effect, bile acid deconjugation, glycocholate, cholesterol assimilation, probiotic strain selection, indigenous lactic acid bacteria

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review