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Cited by 129Mangiferin and Mango ExtractsCardiac Ischemia and ReperfusionCardiac Fibrosis and Remodeling

Mangiferin prevents myocardial infarction‐induced apoptosis and heart failure in mice by activating the Sirt1/FoxO3a pathway

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Chen, Lingli, Li, Santie, Zhu, Jianyu, You, Anfu, Huang, Xingzhou, Yi, Xinchu, Xue, Mei·2021·Journal of Cellular and Molecular Medicine
DOI 10.1111/jcmm.16329PMC PMC7957271
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Abstract

Myocardial infarction (MI) commonly leads to cardiomyocyte apoptosis and heart failure. Mangiferin is a natural glucosylxanthone extracted from mango fruits and leaves, which has anti‐apoptotic and anti‐inflammatory properties in experimental cardiovascular diseases. In the present study, we investigated the role and detailed mechanism of mangiferin in MI. We used ligation of the left anterior descending coronary artery to establish an MI model in vivo, and cardiomyocyte‐specific Sirt1 knockout mice were used to identify the mechanism of mangiferin. For in vitro studies, oxygen and glucose deprivation (OGD) was used to mimic ischaemia in H9c2 cardiomyocytes. In mice, mangiferin treatment increased Sirt1 expression after MI, significantly reduced the infarct area, and prevented MI‐induced apoptosis and heart failure. Mangiferin reduced OGD‐induced cellular apoptosis in H9c2 cells. Meanwhile, Sirt1 knockout/silencing abolished the protective effects of mangiferin. Further studies revealed that mangiferin increased FoxO3a deacetylation by up‐regulating Sirt1, thus preventing apoptosis, and adenovirus‐mediated constitutive acetylation of FoxO3a restricted the anti‐apoptotic effects of mangiferin in vivo and in vitro. Our results indicate that mangiferin prevents cardiomyocyte apoptosis and the subsequent heart failure by activating the Sirt1/FoxO3a pathway in MI, and suggest that mangiferin may have an interesting potential in following studies towards clinical evaluation.

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  • In a randomized, double-blind clinical trial, MGF supplementation markedly decreases serum triglyceride and free fatty acid levels in overweight individuals with hyperlipidemia.

    “A randomized, double-blind clinical trial demonstrated that MGF supplementation can markedly decrease serum triglyceride and free fatty acid levels in overweight individuals with hyperlipidemia, highlighting its clinical potential (146).”

    From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [146]

    The Results passage on MI-induced heart failure reports mangiferin treatment in mice, and the Methods describe experiments in mice and H9c2 cells; no page numbers are available in our copy. Searches for a randomized, double-blind clinical trial, triglycerides, free fatty acids, and hyperlipidemia found no passage reporting the claimed result in overweight people. (LLM, conf=0.76)

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Cited by

Sorted by citations

Authors
Chen, L., Li, S., Zhu, J., You, A., Huang, X., Yi, X., & Xue, M.
Affiliations
  • First Affiliated Hospital of Wenzhou Medical University (CN)
  • Wenzhou Medical University (CN)
Corresponding author
Xue, Mei
ORCID
Venue
Journal of Cellular and Molecular Medicine
Publisher
Wiley
Published
2021-02
Volume
25
Issue
6
Pages
2944-2955
ISSN
  • 1582-1838 (ISSN-L)
  • 1582-4934
DOI
10.1111/jcmm.16329
PMC
PMC7957271
OpenAlex
W3129005952
Cited by
129
References
6
Citations by year
2026: 19 · 2025: 36 · 2024: 48 · 2023: 14 · 2022: 8 · 2021: 4
FWCI
20.84
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Cellular and Molecular Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China
  • Natural Science Foundation of Zhejiang Province
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords
mangiferin, myocardial infarction, cardiomyocyte apoptosis, heart failure, SIRT1, FOXO3, oxygen-glucose deprivation, cardioprotection, SIRT1 knockout mice, H9c2 cells
MeSH terms
Forkhead Box Protein O3, Animals, Cell Survival, Disease Models, Animal, Heart Failure, Mice, Transgenic, Myocardial Infarction, Signal Transduction, Biomarkers, Apoptosis, Myocytes, Cardiac, Xanthones, Mice, Sirtuin 1

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