Mangiferin Improves Hepatic Lipid Metabolism Mainly Through Its Metabolite-Norathyriol by Modulating SIRT-1/AMPK/SREBP-1c Signaling

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Mangiferin prevents myocardial infarction‐induced apoptosis and heart failure in mice by activating the Sirt1/FoxO3a pathway

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Progress in Nonalcoholic Fatty Liver Disease: SIRT Family Regulates Mitochondrial Biogenesis

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Biological Role and Related Natural Products of SIRT1 in Nonalcoholic Fatty Liver

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Virtual screening and in vitro experimental verification of LuxS inhibitors from natural products for Lactobacillus reuteri

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CRISPR/Cas9 Based Knockout of miR-145 Affects Intracellular Fatty Acid Metabolism by Targeting INSIG1 in Goat Mammary Epithelial Cells

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Antiproliferative, Antiangiogenic, and Antimetastatic Therapy Response by Mangiferin in a Syngeneic Immunocompetent Colorectal Cancer Mouse Model Involves Changes in Mitochondrial Energy Metabolism

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Mangiferin for the Management of Liver Diseases: A Review

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Oral administration of mangiferin ameliorates diabetes in animal models: a meta-analysis and systematic review

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Mangiferin Inhibits PDGF‐BB‐Induced Proliferation and Migration of Rat Vascular Smooth Muscle Cells and Alleviates Neointimal Formation in Mice through the AMPK/Drp1 Axis

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Vitexin Attenuates Non-alcoholic Fatty Liver Disease Lipid Accumulation in High Fat-Diet Fed Mice by Activating Autophagy and Reducing Endoplasmic Reticulum Stress in Liver

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6′-O-acetyl mangiferin from Iris rossii Baker inhibits lipid accumulation partly via AMPK activation in adipogenesis

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Stigmasterol and gastrodin, two major components of banxia-baizhu-tianma decoction, alleviated the excessive phlegm-dampness hypertension by reducing lipid accumulation

Zhang, H., Sun, Y., Zou, Y., Chen, C., & Wang, S. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117193 · Cited by 16 · see citing works

Combination of mangiferin and T0901317 targeting autophagy promotes cholesterol efflux from macrophage foam cell in atherosclerosis

Chen, Q., Wang, S., Bao, R., Wang, D., Wu, Y., Zhang, Y., Liu, M., & Wang, T. (2024) · Chinese Medicine · doi:10.1186/s13020-023-00876-9 · Cited by 16 · see citing works

Targeting lipid droplets and lipid droplet-associated proteins: a new perspective on natural compounds against metabolic diseases

Jiang, X., Wang, H., Nie, K., Gao, Y., Shen, C., Tang, Y., Wang, Z., Su, H., & Dong, H. (2024) · Chinese Medicine · doi:10.1186/s13020-024-00988-w · Cited by 17 · see citing works

Comprehensive Profiling of Mangiferin Metabolites In Vivo and In Vitro Based on the “Drug Metabolite Clusters” Analytical Strategy

Zhou, H., Song, S., Lan, X., Li, Y., Yuan, X., Yang, J., Li, M., Cao, T., & Zhang, J. (2023) · ACS Omega · doi:10.1021/acsomega.2c07089 · Cited by 15 · see citing works

Therapeutic Effects of Heterotrigona itama (Stingless Bee) Bee Bread in Improving Hepatic Lipid Metabolism through the Activation of the Keap1/Nrf2 Signaling Pathway in an Obese Rat Model

Zakaria, Z., Othman, Z. A., Suleiman, J. B., Mustaffa, K. M. F., Jalil, N. A. C., Ghazali, W. S. W., Zulkipli, N. N., Mohamed, M., & Kamaruzaman, K. A. (2022) · Antioxidants · doi:10.3390/antiox11112190 · Cited by 15 · see citing works

Leaves of Lippia triphylla improve hepatic lipid metabolism via activating AMPK to regulate lipid synthesis and degradation

Zhang, Y., Liu, M., Chen, Q., Wang, T., Xu, J., Xu, J., & Wang, T. (2019) · Journal of Natural Medicines · doi:10.1007/s11418-019-01316-5 · Cited by 15 · see citing works

Discovery of potent PTP1B inhibitors via structure-based drug design, synthesis and in vitro bioassay of Norathyriol derivatives

Xue, W., Tian, J., Wang, X. S., Xia, J., & Wu, S. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.01.059 · Cited by 15 · see citing works

SIRT1 Activator E1231 Alleviates Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism

Han, J., Li, S., Wang, W., Jiang, X., Liu, C., Lei, L., Li, Y., Sheng, R., Zhang, Y., Wu, Y., et al. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45060321 · Cited by 14 · see citing works

Aerobic bioconversion of <i>C</i>-glycoside mangiferin into its aglycone norathyriol by an isolated mouse intestinal bacterium

Hasanah, U., Miki, K., Nitoda, T., & Kanzaki, H. (2021) · Bioscience, Biotechnology, and Biochemistry · doi:10.1093/bbb/zbaa121 · Cited by 13 · see citing works

Lactucin ameliorates FFA-induced steatosis in HepG2 cells by modulating mitochondrial homeostasis through the SIRT1/PGC-1α signaling axis

Lei, Y., Ma, X., Liu, T., Wang, M., Kang, J., Yang, J. Q., & Mi, N. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e39890 · Cited by 13 · see citing works

Synthesis and structure–activity relationships of pyrazolo‐[3,4‐b]pyridine derivatives as adenosine 5'‐monophosphate‐activated protein kinase activators

Zheng, B., Peng, Y., Wu, W., Ma, J., Zhang, Y., Guo, Y., Sun, S., Chen, Z., Li, Q., & Hu, G. (2019) · Archiv der Pharmazie · doi:10.1002/ardp.201900066 · Cited by 13 · see citing works

β-Aminoisobutyric acid supplementation attenuated salt-sensitive hypertension in Dahl salt-sensitive rats through prevention of insufficient fumarase

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Electromagnetic fields ameliorate hepatic lipid accumulation and oxidative stress: potential role of CaMKKβ/AMPK/SREBP-1c and Nrf2 pathways

Zhai, M., Zhang, C., Cui, J., Liu, J., Li, Y., Xie, K., Luo, E., & Tang, C. (2023) · BioMedical Engineering OnLine · doi:10.1186/s12938-023-01114-x · Cited by 11 · see citing works

Jiangtang Tiaozhi formula ameliorates MASLD by regulating liver ABCD2/PEX2/ATGL axis-mediated fatty acid metabolic reprogramming

Miao, R., Zhang, Y., Zhang, Y., Fang, X., Yin, R., & Tian, J. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157032 · Cited by 10 · see citing works

Design, synthesis, and biological evaluation of 1,2,4‐oxadiazole‐containing pyrazolo[3,4‐b]pyridinones as a new series of AMPKɑ1β1γ1 activators

Xiao, Z., Peng, Y., Zheng, B., Chang, Q., Guo, Y., Chen, Z., Li, Q., & Hu, G. (2021) · Archiv der Pharmazie · doi:10.1002/ardp.202000458 · Cited by 10 · see citing works

Mangiferin protects mesenchymal stem cells against DNA damage and cellular aging via SIRT1 activation

Lim, G. M., & Cho, G.-W. (2025) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2025.112038 · Cited by 9 · see citing works

Mangiferin and EGCG Compounds Fight Against Hyperlipidemia by Promoting FFA Oxidation via AMPK/PPARα

Xu, Y., Zhang, J., Zhang, T., Zi, M., & Zhang, Q. (2024) · PPAR Research · doi:10.1155/ppar/7178801 · Cited by 8 · see citing works

Apelin alleviates sepsis-induced acute lung injury in part by modulating the SIRT1/NLRP3 pathway to inhibit endothelial cell pyroptosis

Zhang, M., Ning, J., & Yu, L. (2023) · Tissue and Cell · doi:10.1016/j.tice.2023.102251 · Cited by 8 · see citing works

Mangiferin inhibits hypoxia/reoxygenation‑induced alveolar epithelial cell injury via the SIRT1/AMPK signaling pathway

Chen, X., & Huang, J. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10654 · Cited by 7 · see citing works

Ameliorative effect of mangiferin on high fat diet - Diethylnitrosamine induced non-alcoholic steatohepatitis rats

Kumar, S. N., Darvin, S. S., Toppo, E., Porchezhiyan, V., Pandikumar, P., Paulraj, M. G., & Savarimuthu Ignacimuthu, S. J. (2022) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2022.102312 · Cited by 6 · see citing works

Integrated serum and liver metabolomics decipher the hepatoprotective mechanisms of mangiferin sodium salt through modulating alcohol metabolism on alcoholic liver disease

Li, Z., Pu, Z., Gao, Y., Zhou, M., Zhang, Z., Xiao, P., Chen, J., & Zhou, C. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.104631 · Cited by 7 · see citing works

Mango ( Mangifera indica L.) By-products in Food Processing and Health Promotion

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Synthesis of natural 3′-Prenylchalconaringenin and biological evaluation of ameliorating non-alcoholic fatty liver disease and metabolic syndrome

Zhang, M., Wang, Z., Hao, S., Hao, L., Zhang, X., Yu, P., & Sun, H. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112649 · Cited by 7 · see citing works

Dietary Methionine Hydroxy Analog Regulates Hepatic Lipid Metabolism via SIRT1/AMPK Signaling Pathways in Largemouth Bass Micropterus salmodies

Zhao, J., Yang, Z., Liu, H., Yang, C., Chen, Y., Cao, Q., & Jiang, J. (2025) · Biology · doi:10.3390/biology14030227 · Cited by 6 · see citing works

Food Minor Bioactive Compounds of Polyphenolic and Polyprenolic Nature Are Promising Agents for the Prevention and Therapy of Non-Alcoholic Fatty Liver Disease

Балакина, А. С., Sidorova, Y. S., Petrov, N. A., & Александрович, Ш. В. (2025) · Molecules · doi:10.3390/molecules30183791 · Cited by 6 · see citing works

Mangiferin reduces high-starch diet-induced lipid accumulation and liver damage by modulating triglyceride metabolism in largemouth bass (Micropterus salmoides)

Zheng, Y., Lu, Q., Cao, J., Han, G., Liu, Y., Liu, H., Jin, J., Zhang, Z., Yang, Y., Zhu, X., et al. (2024) · Aquaculture Reports · doi:10.1016/j.aqrep.2024.102266 · Cited by 6 · see citing works

AMPK-Mediated Hypolipidemic Effects of a Salvia miltiorrhiza and Paeonia lactiflora Mixed Extract on High-Fat Diet-Induced Liver Triglyceride Accumulation: An In Vivo and In Vitro Study

Son, J., Phong, N. V., Cha, M., Oh, B., Song, S., & Yang, S. Y. (2024) · Nutrients · doi:10.3390/nu16183189 · Cited by 6 · see citing works

The protective effects of mangiferin on metabolic and organs functions in the adolescent rat model of alcohol abuse

Chu, C., Li, M., Li, J., & Zhou, C. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.04.056 · Cited by 6 · see citing works

Fibroblast growth factor 21 alleviates acetaminophen induced acute liver injury by activating Sirt1 mediated autophagy

Xu, G., Qiu, F. X., Zhang, W., Li, S., Chen, J., Wang, G., Wang, Y., Pan, J., & Pan, X. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111379 · Cited by 5 · see citing works

El Sistema de Endocannabinoides como regulador de la lipogénesis y su posible modulación por la mangiferina

Soria-Lara, D. M., Gaitán-Vélez, B. V., Jiménez‐Islas, H., & Miranda‐López, R. (2019) · REVISTA BIOMÉDICA · doi:10.32776/revbiomed.v30i2.638 · Cited by 5 · see citing works

The interactive effect of dietary inclusion levels and preparation methods of myo-inositol on growth performance, antioxidant function and lipid metabolism homeostasis of Cyprinus carpio var. jian

Luo, C., Lin, Y., Miao, L., Liu, B., & Ge, X. (2022) · Aquaculture Reports · doi:10.1016/j.aqrep.2022.101249 · Cited by 5 · see citing works

7′-Hydroxyl substituted xanthones from Gentianella acuta revert hepatic steatosis in obese diabetic mice through preserving mitochondrial homeostasis

Li, J., Wu, J., Chen, Q., Yu, H., Liu, M., Wang, Y., Zhang, Y., & Wang, T. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116878 · Cited by 4 · see citing works

Diet-inducing hypercholesterolemia show decreased O-GlcNAcylation of liver proteins through modulation of AMPK

Jagannath, S., Mallanna, S. H., & Nandini, C. (2023) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-023-00997-7 · Cited by 4 · see citing works

Polyphenolic Profiling of Forestry Waste by UPLC-HDMSE

Potter, C. M., & Jones, D. L. (2020) · Processes · doi:10.3390/pr8111411 · Cited by 4 · see citing works

Mangiferin in human disease: Multifaceted mechanisms and applications (Review)

Dai, Y., Huang, Q., Tan, M., Wang, Z., Jiang, C., Liu, Z., Zhang, S., & Song, S. (2026) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2026.5736 · Cited by 3 · see citing works

Novel mangiferin derivatives attenuate adipogenesis in 3T3-L1 preadipocytes and ameliorate diet induced obesity in C57BL/6J mice

Gu, D.-Q., Li, Y., Wu, L., Lyu, M.-T., Li, Y., Huang, S.-Z., Xu, F.-Q., Wu, D., & Zhou, W.-X. (2025) · RSC Medicinal Chemistry · doi:10.1039/d5md00264h · Cited by 3 · see citing works

Unlocking Mangiferin: A Therapeutic Candidate Revolutionizing Liver Disease Therapy

Xie, J., Su, S., Wu, J., Xing, Y., Zhang, Q., Shen, X., Zhao, L., Wang, T., Feng, N., Su, J., et al. (2025) · Nutrients · doi:10.3390/nu17213401 · Cited by 3 · see citing works

Mangiferin as a nutritional strategy to enhance growth performance, feed efficiency, and physiological well-being in heat-stressed growing rabbits

Elmorsy, E. M., Al-Ghafari, A. B., Doghaither, H. A. A., Alyamani, S. A., Hifni, B. A., El‐Raghi, A. A., Hassan, M. A. E., & Embaby, E. M. (2025) · Italian Journal of Animal Science · doi:10.1080/1828051x.2025.2582395 · Cited by 3 · see citing works

Advances in Mangiferin: Biosynthetic Pathways, Bioavailability and Bioactivity

López-Cárdenas, F. G., Pérez‐Jiménez, J., Mateos, R., Zamora-Gasga, V. M., Sánchez-Burgos, J. A., & Sáyago‐Ayerdi, S. G. (2023) · Springer eBooks · doi:10.1007/978-3-030-94753-8_53-1 · Cited by 3 · see citing works

Dietary supplementation with a phytocomplex affects blood parameters and milk yield and quality in grazing goats

Mastellone, V., Morittu, V. M., Musco, N., Spina, A. A., Malgeri, A., Molinari, M. L., D’Aniello, B., Infascelli, F., Tudisco, R., & Lombardi, P. (2021) · Small Ruminant Research · doi:10.1016/j.smallrumres.2021.106421 · Cited by 3 · see citing works

Metabolomics integrated with network pharmacology and serum-urine pharmacochemistry unveils the antidiabetic mechanism of Anemarrhenae Rhizoma

Zhong, X., Peng, H., Chang, X., Xiao, C., Zhu, X., Liang, H., Wang, R., Zhong, Y., & Feng, J. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1618584 · Cited by 2 · see citing works

NAD+-mediated SIRT1–LKB1–AMPK signaling drives lipid remodeling and meat quality differences between Daweishan miniature and Arbor Acres chicken breeds

Wu, H., Luo, J., Jian, Z., Yang, M., Zhao, J., Fu, J., Yan, S., Dou, T., Jia, J., Liu, L., et al. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1711416 · Cited by 2 · see citing works

Transcriptome Analysis Reveals Norathyriol Prolongs the Lifespan via Regulating Metabolism in C. elegans

Zhang, H., Lan, H.-Q., Wang, M., Wang, C., Wei, L.-G., & Xu, C. (2024) · Metabolites · doi:10.3390/metabo14120716 · Cited by 2 · see citing works

Pharmacology of Anti-obesity and Antidiabetic Phytochemicals Isolated from Various Natural Sources (Plants, Seaweeds, Mushrooms, Marine Animals, and Microorganisms)

Dinda, B., Dinda, S., & Chakraborty, M. (2022) · Springer eBooks · doi:10.1007/978-3-030-92196-5_5 · Cited by 2 · see citing works

Perspectives on the potential of Mangiferin as a nutraceutical: a review

Jamwal, D., Saini, P., Tomar, P. C., & Ghosh, A. (2022) · Nutrition & Food Science · doi:10.1108/nfs-01-2022-0013 · Cited by 2 · see citing works

Lipid metabolism in cancer is regulated by the integrated natural product–miRNA–target axis

Chuang, Y.-T., Yen, C.-Y., Tsai, Y., Chang, F., Farooqı, A. A., & Chang, H.-W. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.11.024 · Cited by 1 · see citing works

Discovery of mangiferin lipophilic amide derivatives as novel fatty acid synthase inhibitors with potent anti-hepatocellular carcinoma activity

Li, Y., Wu, L.-S., Lyu, M.-T., Li, Y., Wang, T., Xu, F.-Q., Wu, D.-L., & Zhou, W.-X. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.109592 · Cited by 1 · see citing works

Mangiferin as a Multilevel Modulator of Metabolic Syndrome: Current Evidence and Future Perspectives

Ramos-Olvera, J. A., Torres-Valencia, J. M., Ortiz, M. I., Fernández‐Martínez, E., Gómez‐Aldapa, C. A., Muñoz‐Pérez, V. M., & Cariño‐Cortés, R. (2026) · Metabolites · doi:10.3390/metabo16070453 · Cited by 1 · see citing works

1-Methylnicotinamide promotes hepatic steatosis in mice: A potential mechanism in chronic alcohol-induced fatty liver disease

Lai, S., Ma, Y., Hao, L., Ding, Q., Chang, K., Zhuge, H., Qiu, J., Xu, T., Dou, X., & Li, S. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2023.159286 · Cited by 1 · see citing works

Electromagnetic Fields Ameliorate Hepatic Lipid Accumulation and Oxidative Stress by Activating the CaMKKβ/AMPK/SREBP-1c and Nrf2 Pathways in High-Fat Diet-Fed MicePreprint

Zhai, M., Cui, J., Zhang, C., Liu, J., Li, Y., Xie, K., Luo, E., & Tang, C. (2021) · Research Square · doi:10.21203/rs.3.rs-1018391/v1 · Cited by 1 · see citing works

Exploring the Protective Effects and Mechanism of Huaji Jianpi Decoction against Nonalcoholic Fatty Liver Disease by Network Pharmacology and Experimental Validation

Xue, H., Wang, Y., Xiang, H.-W., Song, Q., Zhang, G., Wang, J., & Ge, S. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/5440347

Uncarboxylated Osteocalcin Inhibits De Novo Lipogenesis and Promotes Fatty Acid Oxidation via SIRT1 to Alleviate Hepatocyte Lipid AccumulationPreprint

Chen, L., Zhang, M., Xu, J., & Yang, J. (2024) · Research Square · doi:10.21203/rs.3.rs-3856420/v1

Additional file 1 of Combination of mangiferin and T0901317 targeting autophagy promotes cholesterol efflux from macrophage foam cell in atherosclerosis

Chen, Q., Wang, S., Bao, R., Wang, D., Wu, Y., Zhang, Y., Liu, M., & Wang, T. (2024) · Figshare · doi:10.6084/m9.figshare.26663530

Cordycepin Ameliorates Constant Light-Induced Thermogenic Dysfunction in Brown Adipose Tissue by Activating SIRT1-Mediated Mitochondrial Homeostasis

Bi, Y., Zhang, G. L., Wang, Y., Zhang, L., Wu, S., Zhang, Y., Li, X., & Yang, D. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27104351

Astragaloside IV improves MASLD via GCN5-LXRα/SREBP1c signaling pathway-mediated hepatic de novo lipogenesis

Hui-mei, L., Xu, Y.-Y., Miao, K., Xiao, H.-T., Wang, Y., Jin, J., Wu, H., Chen, B.-Y., Xu, L., Zhu, J.-P., et al. (2026) · Chinese Medicine · doi:10.1186/s13020-026-01491-0

Mangiferin decreases plasma free fatty acids through promoting its catabolism in liver by activation of AMPK

Niu, Y., Li, S., Na, L., Feng, R., Liu, L., Li, Y., & Sun, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030782 · Cited by 116 · see citing works

Beneficial effects of mangiferin on hyperlipidemia in high-fat-fed hamsters

Guo, F., Huang, C., Liao, X., Wang, Y., He, Y., Feng, R., Li, Y., & Sun, C. (2011) · Molecular Nutrition &amp; Food Research · doi:10.1002/mnfr.201100392 · Cited by 118 · see citing works

Mangiferin treatment inhibits hepatic expression of acyl-coenzyme A: Diacylglycerol acyltransferase-2 in fructose-fed spontaneously hypertensive rats: A link to amelioration of fatty liver

Xing, X., Li, D., Chen, D., Zhou, L., Chonan, R., Yamahara, J., Wang, J., & Li, Y. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.08.001 · Cited by 46 · see citing works

Mangiferin alleviates metabolic-associated fatty liver disease by modulating gut microbiota and FXR signaling pathway to regulate bile acid metabolism

Zheng, L., Xie, Q., Si, Y., Chen, M., Zhao, W. B., Li, R., Cheng, J., & Zhang, Y. X. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1844895

Dual mode action of mangiferin in mouse liver under high fat diet

Lim, J., Liu, Z., Apontes, P., Feng, D., Pessin, J. E., Sauve, A. A., Angeletti, R. H., & Chi, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090137 · Cited by 64 · see citing works